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Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Dualde, P
  • Pardo, O
  • Corpas-Burgos, F
  • Pastor, A
  • Yusa, V

Grupos

Abstract

In this study, we assessed the presence of four parabens in human milk of 120 mothers from Valencia (Spain) which took part in a human biomonitoring project (BETTERMILK). The detection frequency ranges of parabens were 41-60% and 61-89% for unconjugated- and total (unconjugated+conjugated)-parabens, respectively. The concentrations ranged from LoQ to 31ng/mL and from LoQ to 49ng/mL for unconjugated- and total-parabens, respectively. The frequency of use of some cosmetic products and human milk protein levels were the main predictors of parabens in milk. The study evidences the presence of both conjugated and unconjugated paraben forms in human milk. The newborns estimated daily intake of parabens through human milk was several orders of magnitude lower than the 0-10mg/kg bw-day acceptable daily intake for the sum of methyl and ethyl paraben established by EFSA. To our knowledge, this is currently the largest biomonitoring study of parabens in human milk.

Datos de la publicación

ISSN/ISSNe:
0045-6535, 1879-1298

Chemosphere  PERGAMON-ELSEVIER SCIENCE LTD

Tipo:
Article
Páginas:
124829-124829
PubMed:
31563722
Factor de Impacto:
1,632 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 23

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Keywords

  • Estimated daily intake, Human biomonitoring, Human milk, Infants, Mothers, Parabens

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