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Vitamin A Deficiency and the Lung.

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Timoneda, J
  • Rodriguez-Fernandez, L
  • Zaragoza, R
  • Cabezuelo, MT
  • Torres, L
  • Viña JR
  • Barber, T

Abstract

Vitamin A (all- trans -retinol) is a fat-soluble micronutrient which together with its natural derivatives and synthetic analogues constitutes the group of retinoids. They are involved in a wide range of physiological processes such as embryonic development, vision, immunity and cellular differentiation and proliferation. Retinoic acid (RA) is the main active form of vitamin A and multiple genes respond to RA signalling through transcriptional and non-transcriptional mechanisms. Vitamin A deficiency (VAD) is a remarkable public health problem. An adequate vitamin A intake is required in early lung development, alveolar formation, tissue maintenance and regeneration. In fact, chronic VAD has been associated with histopathological changes in the pulmonary epithelial lining that disrupt the normal lung physiology predisposing to severe tissue dysfunction and respiratory diseases. In addition, there are important alterations of the structure and composition of extracellular matrix with thickening of the alveolar basement membrane and ectopic deposition of collagen I. In this review, we show our recent findings on the modification of cell-junction proteins in VAD lungs, summarize up-to-date information related to the effects of chronic VAD in the impairment of lung physiology and pulmonary disease which represent a major global health problem and provide an overview of possible pathways involved.

Datos de la publicación

ISSN/ISSNe:
2072-6643, 2072-6643

Nutrients  MDPI

Tipo:
Article
Páginas:
-
PubMed:
30134568
Factor de Impacto:
1,493 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 90

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Keywords

  • E-cadherin, N-cadherin, Vitamin A deficiency, collagen, epithelial–mesenchymal transition, extracellular matrix, lung, pulmonary disease, retinoic acid, retinol

Proyectos y Estudios Clínicos

SEGUIMIENTO DE PACIENTES SOMETIDOS A TRASPLANTE CARDIACO. ESTUDIO DE MARCADORES DE RECHAZO IMPLICADOS EN EL TRANSPORTE NÚCLEO-CITOPLASMA.

Investigador Principal: ESTHER ROSELLÓ LLETÍ

PI14/01506 . INSTITUTO DE SALUD CARLOS III . 2015

IDENTIFICACIÓN Y CLASIFICACIÓN DE RECHAZO CARDÍACO MEDIANTE MARCADORES IMPLICADOS EN LA HOMEOSTASIAS DEL CALCIO Y TRANSPORTE INTRACELULAR.

Investigador Principal: ESTHER ROSELLÓ LLETÍ

PI17/01925 . INSTITUTO DE SALUD CARLOS III . 2018

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