Precision medicine in obstructive sleep apnoea

Fecha de publicación: 01/05/2019

Autores de IIS La Fe

Miguel Ángel Martínez García

Autor

Participantes ajenos a IIS La Fe

Campos-Rodriguez, F
Barbe, F
Gozal, D
Agusti, A

Grupos

Neumología

Leader

Miguel Ángel Martínez García

Abstract

Obstructive sleep apnoea (OSA) is a heterogeneous and complex disease; however, diagnosis and management still rely on a simple set of tools and few therapeutic options. Precision medicine has emerged as the next goal for clinical practice, with the objective being to offer individually tailored treatments. Ways of implementing precision medicine in clinical practice have emerged for various respiratory disorders, and such an approach could also be readily exported to OSA. Here, we propose a control panel tool that describes OSA in four domains: disease severity, biological activity, impact on the patient, and pathophysiological traits. We also propose a graphical instrument, the clinical fingerprint tool, to enable the tracking of patients over time. These tools can address the complexity of OSA and guide a physician's course of action on the basis of the treatable traits of an individual patient, thereby facilitating clinical implementation of precision medicine in the disorder.

Datos de la publicación

ISSN/ISSNe:: 2213-2600, 2213-2619
Tipo:: Article
Páginas:: 456-464
DOI:: 10.1016/S2213-2600(19)30044-X
PubMed:: 30987857
Factor de Impacto:: 7,516 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Martinez-Garcia, MA:: Polytech & Univ Hosp La Fe, Resp Dept, Valencia 46026, Spain
Campos-Rodriguez, F:: Ctr Invest Biomed Red Enfermedades Resp, Madrid, Spain

Valme Univ Hosp, Resp Dept, Seville, Spain

Inst Biomed Sevilla, Seville, Spain
Barbe, F:: Ctr Invest Biomed Red Enfermedades Resp, Madrid, Spain

Inst Recerca Biomed Lleida, Lleida, Spain
Gozal, D:: Univ Missouri, Dept Child Hlth, Columbia, MO 65201 USA
Agusti, A:: Ctr Invest Biomed Red Enfermedades Resp, Madrid, Spain

Hosp Clin Barcelona, Inst Resp, Dept Paediat, Barcelona, Spain

Univ Barcelona, Resp Dept, Barcelona, Spain

Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain