Portal de investigación
Mesoporous Silica-Based Materials with Bactericidal Properties
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Bernardos, A
- Piacenza, E
- Sancenon, F
- Hamidi, M
- Maleki, A
- Turner, RJ
Grupos
Abstract
Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM-based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS-loaded with antimicrobial agents, gated MS-loaded with antimicrobial agents, MS with metal-based nanoparticles, and MS-loaded with metal ions) is provided.
Datos de la publicación
- ISSN/ISSNe:
- 1613-6810, 1613-6829
- Tipo:
- Review
- Páginas:
- -
- Factor de Impacto:
- 3,717 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Small Wiley - V C H Verlag GmbbH & Co.
Citas Recibidas en Web of Science: 100
Documentos
- No hay documentos
Filiaciones
Keywords
- antibiotics; controllable drug delivery systems; mesoporous silica materials; nanoparticles
Proyectos asociados
NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMÉDICO
Investigador Principal: JUAN BAUTISTA SALOM SANVALERO
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Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
PTA2016-12603-1 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD . 2018
Contrato I-PFIS: Predoctorales de formación en investigación en salud.
Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
IFI17/00039 . INSTITUTO DE SALUD CARLOS III . 2018
Contrato Post FSE (Rio Hortega)
Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
CM18/00078 . INSTITUTO DE SALUD CARLOS III . 2019
PLATAFORMA PARA LA DETECCIÓN DE PATÓGENOS BASADA EN MATERIALES CON PUERTAS MOLECULARES (PATH-GATE).
Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ
DTS18/00090 . INSTITUTO DE SALUD CARLOS III . 2019
Cita
Bernardos A,Piacenza E,Sancenon F,Hamidi M,Maleki A,Turner RJ,Martinez R. Mesoporous Silica-Based Materials with Bactericidal Properties. Small. 2019. 15(24):1900669. IF:11,459. (1).