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  3. Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

Fecha de publicación:

Autores de IIS La Fe

  • Maria Garcia Dasi

    Autor

  • Paula Garcia Belda

    Autor

  • Elisabet Rodriguez Tarrega

    Autor

  • Julia Romero Moreno

    Autor

  • Maria Amparo Martinez Blasco

    Autor

Participantes ajenos a IIS La Fe

  • Ruiz-de-Leon, MJ
  • Jimenez-Sousa, MA
  • Moreno, S
  • Gutierrez-Rivas, M
  • Leon, A
  • Gonzalez-Garcia, J
  • Resino, S
  • Rallon, N
  • Benito, JM
  • Vallejo, A
  • Benito, JM
  • Ratlon, N
  • Restrepo, C
  • Rodriguez, N
  • Garcia, M
  • Cabello, A
  • Gorgolas, M
  • Resino, S
  • Briz, V
  • Jimenez, MA
  • Vazquez, MS
  • Fernandez, A
  • Munoz, MA
  • Sanchez, J
  • Jimenez, JL
  • Sepulveda, D
  • Garcia, I
  • Consuegra, I
  • Leon, A
  • Arnedo, M
  • Plana, M
  • Climent, N
  • Garcia, F
  • Ruiz-Mateos, E
  • Dominguez, B
  • Tarancon, L
  • Rafii-Elddrissi, M
  • Polaino, MJ
  • Genebat, M
  • Viciana, P
  • Leal, M
  • Vidal, F
  • Vilades, C
  • Peraire, J
  • Rodriguez, C
  • Vera, M
  • Este, J
  • Ballana, E
  • Franco, S
  • Nevot, M
  • Vallejo, A
  • Moreno, S
  • Pernas, M
  • Casado, C
  • Lopez, C
  • Capa, L
  • Perez, M
  • Alcami, J
  • Sanjuan, R
  • Cuevas, JM
  • Delgado, R
  • Sierra, O

Grupos

Abstract

Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found. Copyright (C) 2018, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.

Datos de la publicación

ISSN/ISSNe:
1684-1182, 1995-9133

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION  ELSEVIER TAIWAN

Tipo:
Article
Páginas:
667-671
PubMed:
30193823
Factor de Impacto:
0,947 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 15

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Keywords

  • Exosomes; miRNAs; HIV-1; Elite controllers; Immune activation; Soluble biomarkers

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