The Effect of Morbidity and Sex on Postnatal Growth of Very Preterm Infants: A Multicenter Cohort Study

Data de publicació: 01/01/2019

Autors de IIS La Fe

Máximo Vento Torres

Autor

Autors aliens a IIS La Fe

Zozaya, C
Avila-Alvarez, A
Arruza, L
Rodrigo, FGM
Fernandez-Perez, C
Castro, A
Cuesta, MT
Vacas, B
Couce, ML
de Pipaon, MS

Grups d'Investigació

Perinatología

Leader

Máximo Vento Torres

Abstract

Background: Extrauterine growth restriction is common in the preterm infant, and it is associated with poor neurodevelopment. Nutrition plays an important role in postnatal growth, but growth is also influenced by other factors like co-morbidity, and, also, there might be sex differences. Methods: This is a cohort study including preterm infants < 32 weeks at birth (n = 21,825) from the Spanish Neonatal Network database. The effect of sex and morbidity (patent ductus arteriosus, bronchopulmonary dysplasia, necrotizing enterocolitis and late-onset sepsis) on weight gain as well as linear and head growth from birth to discharge/death was assessed with linear regression models adjusted by gestational age and Z-scores at birth. Results: The 4 selected morbidities had an independent effect on all 6 growth parameters studied, which was greater in the case of necrotizing enterocolitis: changes in weight, length and head Z-scores were -0.60 (95% CI: -0.66 to -0.55), -0.62 (95% CI: -0.70 to -0.54) and -0.63 (95% CI: -0.71 to -0.56), respectively. Weight gain and linear growth were overall more affected than head growth. Girls lost slightly more weight Z-scores (-0.03; 95% CI: -0.06 to -0.002) than boys after adjustment by morbidity. There were no significant gender differences regarding linear and head growth velocity (cm/week), although girls lost more head Z-scores (-0.14; 95% CI: -0.18 to -0.10). Conclusions: Main co-morbidities associated with prematurity have an impact on postnatal growth. Head growth is less affected than length and weight. Girls are at slightly higher risk of postnatal weight and head restriction after adjustment by morbidity. (c) 2019 S. Karger AG, Basel

Dades de la publicació

ISSN/ISSNe:: 1661-7800, 1661-7819
Tipus:: Article
Pàgines:: 348-354
DOI:: 10.1159/000497221
PubMed:: 30893696
Factor d'Impacte:: 1,178 SCImago ℠
Quartil:: Q1 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Zozaya, C:: Hosp Sick Children, Div Neonatol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
Avila-Alvarez, A:: Complexo Hosp Univ A Coruna, Dept Paediat, Neonatal Unit, La Coruna, Spain
Arruza, L:: Hosp Clin San Carlos, Div Neonatol, Madrid, Spain
Rodrigo, FGM:: Complejo Hosp Univ Insular Maternoinfantil, Div Neonatol, Las Palmas Gran Canaria, Spain
Fernandez-Perez, C:: Hosp Clin San Carlos, Div Prevent Med, Madrid, Spain
Castro, A:: Hosp Virgen del Camino, Complejo Hosp Navarra, Dept Pediat, Neonatal Unit, Pamplona, Spain
Cuesta, MT:: Hosp Infanta Cristina, Dept Paediat, Neonatal Unit, Parla, Spain
Vacas, B:: Complejo Asistencial Salamanca, Neonatal Unit, Salamanca, Spain
Couce, ML:: Complexo Hosp Univ Santiago de Compostela, Dept Neonatol, Santiago De Compostela, Spain
Torres, MV:: Hosp Univ & Politecn La Fe, Dept Neonatol, Valencia, Spain
de Pipaon, MS:: Hosp Univ La Paz, Dept Neonatol, Madrid, Spain