Portal de investigación
Neurocognitive endophenotypes in schizophrenia and bipolar disorder: A systematic review of longitudinal family studies.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Tabares-Seisdedos, R
- Vieta, E
- Cuesta, MJ
Grupos
Abstract
Although there is substantial evidence supporting the existence of neurocognitive impairment in patients diagnosed with schizophrenia (SZ) and bipolar disorder (BD), few studies have explored the field from an endophenotypic perspective. The present systematic review sought to identify longitudinal family studies exploring suitable neurocognitive endophenotypes in unaffected relatives of patients with SZ and/or BD. Following the PRISMA statement, only five follow-up studies met the inclusion criteria, comprising 79 SZ patients, 159 SZ unaffected relatives of SZ, 131 BD patients, 77 unaffected relatives of BD, and 248 controls. Verbal memory, auditory attention, face memory and emotion processing were found as putative endophenotypic candidates for SZ, whereas this strategy identified none for BD. Substantial heterogeneity and lack of standardization in global neurocognitive assessment within this area should be pointed out; nevertheless, several candidate endophenotypes were identified for SZ, except for executive impairment.
Datos de la publicación
- ISSN/ISSNe:
- 0920-9964, 1573-2509
- Tipo:
- Article
- Páginas:
- 21-29
- Factor de Impacto:
- 1,796 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
SCHIZOPHRENIA RESEARCH ELSEVIER SCIENCE BV
Citas Recibidas en Web of Science: 16
Documentos
- No hay documentos
Filiaciones
Keywords
- Bipolar disorder, Cognitive impairment, Endophenotypes, Neurocognition, Schizophrenia, Unaffected relatives
Proyectos asociados
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SM I 22/2011 . 2012
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FCT-13-7457_FECYT_2013 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013
CARACTERIZACIÓN EPIGENÓMICA DE LA ANOREXIA NERVIOSA. MODELO DE GEMELAS MONOCIGOTAS DISCORDANTES Y VALIDACIÓN EN POBLACIÓN GENERAL.
Investigador Principal: LUIS MIGUEL ROJO MORENO
PI16/01279 . INSTITUTO DE SALUD CARLOS III . 2017
INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.
Investigador Principal: VICENT BALANZA MARTINEZ
PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017
Cita
Luperdi SC,Tabares R,Livianos L,Vieta E,Cuesta MJ,Balanza V. Neurocognitive endophenotypes in schizophrenia and bipolar disorder: A systematic review of longitudinal family studies. Schizophr Res. 2019. 210. p. 21-29. IF:3,759. (1).