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Neurocognitive endophenotypes in schizophrenia and bipolar disorder: A systematic review of longitudinal family studies.

Data de publicació: Data Ahead of Print:

Autors de IIS La Fe

Autors aliens a IIS La Fe

  • Tabares-Seisdedos, R
  • Vieta, E
  • Cuesta, MJ

Grups d'Investigació

Abstract

Although there is substantial evidence supporting the existence of neurocognitive impairment in patients diagnosed with schizophrenia (SZ) and bipolar disorder (BD), few studies have explored the field from an endophenotypic perspective. The present systematic review sought to identify longitudinal family studies exploring suitable neurocognitive endophenotypes in unaffected relatives of patients with SZ and/or BD. Following the PRISMA statement, only five follow-up studies met the inclusion criteria, comprising 79 SZ patients, 159 SZ unaffected relatives of SZ, 131 BD patients, 77 unaffected relatives of BD, and 248 controls. Verbal memory, auditory attention, face memory and emotion processing were found as putative endophenotypic candidates for SZ, whereas this strategy identified none for BD. Substantial heterogeneity and lack of standardization in global neurocognitive assessment within this area should be pointed out; nevertheless, several candidate endophenotypes were identified for SZ, except for executive impairment.

Dades de la publicació

ISSN/ISSNe:
0920-9964, 1573-2509

SCHIZOPHRENIA RESEARCH  ELSEVIER SCIENCE BV

Tipus:
Article
Pàgines:
21-29
PubMed:
31272906
Factor d'Impacte:
1,796 SCImago ℠
Quartil:
Q1 SCImago ℠

Cites Rebudes en Web of Science: 16

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Keywords

  • Bipolar disorder, Cognitive impairment, Endophenotypes, Neurocognition, Schizophrenia, Unaffected relatives

Projectes associats

EFECTOS DE LA MONOTERAPIA CON LITIO EN EL FUNCIONAMIENTO NEUROPSICOLOGICO DE LOS PACIENTES CON TRASTORNO BIPOLAR

Investigador Principal: LORENZO LIVIANOS ALDANA

SM I 22/2011 . 2012

CON-CIENCIA-YV: PILDORAS DE SALUD

FCT-13-7457_FECYT_2013 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013

CARACTERIZACIÓN EPIGENÓMICA DE LA ANOREXIA NERVIOSA. MODELO DE GEMELAS MONOCIGOTAS DISCORDANTES Y VALIDACIÓN EN POBLACIÓN GENERAL.

Investigador Principal: LUIS MIGUEL ROJO MORENO

PI16/01279 . INSTITUTO DE SALUD CARLOS III . 2017

INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.

Investigador Principal: VICENT BALANZA MARTINEZ

PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017

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