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  3. Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Helmy, R
  • Denhaerynck, K
  • Berben, L
  • Dobbels, F
  • Russell, CL
  • Roza, BD
  • De Geest, S
  • Crespo-Leiro, MG
  • Guppies, S
  • De Simone, P
  • Groenewoud, A
  • Kugler, C
  • Ohler, L
  • Van Cleemput, J
  • Poncelet, AJ
  • Sebbag, L
  • Michel, M
  • Bernard, A
  • Doesch, A
  • Livi, U
  • Potena, L
  • Brossa-Loidi, V
  • Segovia-Cubero, J
  • Saint-Gerons, CS
  • Mohacsi, P
  • Horvath, E
  • Riotto, C
  • Parry, G
  • Firouzi, A
  • Kozuszko, S
  • Haddad, H
  • Kaan, A
  • Fisher, G
  • Miller, T
  • Flattery, M
  • Ludrosky, K
  • Albert, N
  • Coleman, B
  • Trammell, J
  • Epstein, F
  • St Clair, K
  • Kao, A
  • Molina, M
  • Canales, KR
  • de Almeida, SS
  • Ayoub, AC
  • Barone, F
  • Harkess, M
  • Maddicks-Law, J
  • BRIGHT Study Team

Grupos

Abstract

Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0149-2918, 1879-114X

CLINICAL THERAPEUTICS  ELSEVIER

Tipo:
Article
Páginas:
130-136
PubMed:
30591285
Factor de Impacto:
0,981 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 12

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Keywords

  • co-medications; cross-sectional; heart transplantation; immunosuppressants; international; medication adherence

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