MAMI: a birth cohort focused on maternal-infant microbiota during early life

Fecha de publicación: 03/05/2019

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

Garcia-Mantrana, I
Alcantara, C
Selma-Royo, M
Boix-Amoros, A
Dzidic, M
Gimeno-Alcaniz, J
Ubeda-Sansano, I
Sorribes-Monrabal, I
Escuriet, R
Gil-Raga, F
Martinez-Costa, C
Collado, MC
Bauerl, C
Villoldo, E
Zafra, C
Olivares, L
Perez-Martinez, G
Mira, A
Ferrer, MD
Santamaria, JM
Ahicart, A
Bertua-Rios, B
Padilla, B
Crehua-Gaudiza, E
Pereto-Moll, A
Garcia, AR
Rico, MDS
Martinez, NB
Segarra, IR
Soriano, JLT
Blesa-Baviera, LC
Vidal, AP
Hornos, LM
del Moral, TG
Cano, PD
Ferrer, MFI
Delgado, C
Atero, A

Grupos

Perinatología

Leader

Máximo Vento Torres

Abstract

BackgroundEarly microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on infant health programming. This birth cohort is aimed to characterize the maternal microbes transferred to neonates during the first 1000days of life, as well as to identify the potential host and environmental factors, such as gestational age, mode of delivery, maternal/infant diet, and exposure to antibiotics, which affect early microbial colonization.MethodsMAMI is a prospective mother-infant birth cohort in the Spanish-Mediterranean area. Mothers were enrolled at the end of pregnancy and families were follow-up during the first years of life. Maternal-infant biological samples were collected at several time points from birth to 24months of life. Clinical and anthropometric characteristics and dietary information is available. Specific qPCR and 16S rRNA gene sequencing as well as short chain fatty acid (SCFAs) profile would be obtained. Multivariable models will be used to identy associations between microbiota and clinical and anthropometric data controlling for confounders.MAMI would contribute to a better understanding of the interaction between diet, microbiota and host response in early life health programming, enabling new applications in the field of personalized nutrition and medicine.Trial registrationThe study is registered on the ClinicalTrial.gov platform NCT03552939. (June 12, 2018).

Datos de la publicación

ISSN/ISSNe:: 1471-2431, 1471-2431
Tipo:: Article
Páginas:: 140-140
DOI:: 10.1186/s12887-019-1502-y
Factor de Impacto:: 0,853 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Garcia-Mantrana, I:: Inst Agrochemistn & Food Technol Natl Res Council, Dept Biotechnol, Av Agustin Escardino 7, Valencia 46980, Spain

IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Alcantara, C:: Inst Agrochemistn & Food Technol Natl Res Council, Dept Biotechnol, Av Agustin Escardino 7, Valencia 46980, Spain

IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Selma-Royo, M:: Inst Agrochemistn & Food Technol Natl Res Council, Dept Biotechnol, Av Agustin Escardino 7, Valencia 46980, Spain

IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Boix-Amoros, A:: Inst Agrochemistn & Food Technol Natl Res Council, Dept Biotechnol, Av Agustin Escardino 7, Valencia 46980, Spain

IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Dzidic, M:: Inst Agrochemistn & Food Technol Natl Res Council, Dept Biotechnol, Av Agustin Escardino 7, Valencia 46980, Spain

IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Gimeno-Alcaniz, J:: Inst Agrochemistn & Food Technol Natl Res Council, Dept Biotechnol, Av Agustin Escardino 7, Valencia 46980, Spain

IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Ubeda-Sansano, I:: Hlth Care Ctr La Eliana, Valencia, Spain
Sorribes-Monrabal, I:: Hlth Care Ctr Serreria II, Valencia, Spain
Escuriet, R:: Univ Pompeu Fabra, Ctr Res Hlth & Econ, Div Innovat & Cartera Serv Sanitarios, Area Atenc Sanitaria & Serv Salud Generalitat Cat, Barcelona, Spain

Generalitat Catalunya, Div Innovat & Cartera Serv Sanitarios, Area Atenc Sanitaria & Serv Salud, Barcelona, Spain
Gil-Raga, F:: Hosp MANISES, Dept Obstet & Gynaecol, Valencia, Spain

Hosp MANISES, Gynaecol & Obstet, Valencia, Spain
Parra-Llorca, A:: Instituto de Investigación. Hlth Res Inst La Fe, Neonatal Res Grp, Valencia, Spain

Univ & Polytech Hosp La Fe, Div Neonatol, Valencia, Spain
Martinez-Costa, C:: Univ Valencia, Hosp Clin Univ, Dept Pediat, Valencia, Spain

Univ Valencia, Hosp Clin Univ, Pediatricy Grp, Valencia, Spain
Collado, MC:: Inst Agrochemistn & Food Technol Natl Res Council, Dept Biotechnol, Av Agustin Escardino 7, Valencia 46980, Spain

IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Bauerl, C:: IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Villoldo, E:: IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Zafra, C:: IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Olivares, L:: IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Perez-Martinez, G:: IATA CSIC, Dept Biotechnol, Unit Lact Acid Bacteria, Valencia, Spain
Mira, A:: FISABIO GVA, Valencia, Spain
Ferrer, MD:: FISABIO GVA, Valencia, Spain
Santamaria, JM:: FISABIO GVA, Valencia, Spain
Ahicart, A:: FISABIO GVA, Valencia, Spain
Vento, M:: Neonatol Grp, Valencia, Spain
Gormaz, M:: Instituto de Investigación. Hlth Res Inst La Fe, Neonatal Res Grp, Valencia, Spain

Univ & Polytech Hosp La Fe, Div Neonatol, Valencia, Spain
Cernada, M:: Instituto de Investigación. Hlth Res Inst La Fe, Neonatal Res Grp, Valencia, Spain

Univ & Polytech Hosp La Fe, Div Neonatol, Valencia, Spain
Bertua-Rios, B:: Univ Valencia, Hosp Clin Univ, Dept Pediat, Valencia, Spain

Univ Valencia, Hosp Clin Univ, Nutr Res Grp, INCLIVA Biomed Res Inst Valencia, Valencia, Spain
Padilla, B:: Univ Valencia, Hosp Clin Univ, Dept Pediat, Valencia, Spain

Univ Valencia, Hosp Clin Univ, Nutr Res Grp, INCLIVA Biomed Res Inst Valencia, Valencia, Spain
Crehua-Gaudiza, E:: Univ Valencia, Hosp Clin Univ, Dept Pediat, Valencia, Spain

Univ Valencia, Hosp Clin Univ, Nutr Res Grp, INCLIVA Biomed Res Inst Valencia, Valencia, Spain
Pereto-Moll, A:: Univ Valencia, Hosp Clin Univ, Dept Pediat, Valencia, Spain

Univ Valencia, Hosp Clin Univ, Nutr Res Grp, INCLIVA Biomed Res Inst Valencia, Valencia, Spain
Garcia, AR:: Hlth Care Ctr Museros, Valencia, Spain
Rico, MDS:: Hlth Care Ctr Foios, Valencia, Spain
Martinez, NB:: Hosp MANISES, Midwife Dept Obstet & Gynaecol, Valencia, Spain
Segarra, IR:: Hlth Care Ctr La Eliana, Valencia, Spain
Soriano, JLT:: Hlth Care Ctr La Eliana, Valencia, Spain
Blesa-Baviera, LC:: Hlth Care Ctr Serreria II, Valencia, Spain
Vidal, AP:: Hlth Care Ctr Serreria II, Valencia, Spain
Hornos, LM:: Hlth Care Ctr Xiriveila, Valencia, Spain
del Moral, TG:: Cooperat Titania Tasco, Barcelona, Spain
Cano, PD:: Cooperat Titania Tasco, Barcelona, Spain
Ferrer, MFI:: Cooperat Mudra, Barcelona, Spain
Delgado, C:: Casa Parts Mitjorn, Barcelona, Spain
Atero, A:: Casa Parts Mitjorn, Barcelona, Spain