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  3. MECHAGGRENAMICS. MECHANISMS OF CELL DYSFUNCTION BY AGGREGATION DYNAMICS OF POLYQ-CONTAINING PROTEINS

MECHAGGRENAMICS. MECHANISMS OF CELL DYSFUNCTION BY AGGREGATION DYNAMICS OF POLYQ-CONTAINING PROTEINS

Dades bàsiques

Protocol:
322034_MARIE_CURIE_VAZQUEZ_FP7-PEOPLE-2012-CIG
EURDRACT:
NCT:
Centre:
Any inici:
2012
Any de finalització:
2016
PI BIOMÉDICA 100.000,00 €

Objectius del projecte

PENDIENTE

Documents

  • No hi ha documents

Participants

Grups d'Investigació

Finançadors - Promotors

ASOCIACION VALENCIANA DE ENFERMEDAD HUNTINGTON
COMISION EUROPEA

Resultats de l'Assaig Clínic

Caenorhabditis elegans Models to Study the Molecular Biology of Ataxias

Gonzalez-Cabo, Pilar, Vazquez-Manrique, Rafael P.

Capítulo de un Libro. 10.1016/B978-0-12-405195-9.00068-8. 2015


AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

Vázquez-Manrique RP; (...); Neri C

Article. 10.1093/hmg/ddv513. 2016

  • Open Access.

CRISPR to fix bad blood: a new tool in basic and clinical hematology

Gonzalez-Romero, E; (...); Sanjuan-Pla, A

Review. 10.3324/haematol.2018.211359. 2019

  • Open Access.

CRISPR-Cas9 editing of a TNPO3 mutation in a muscle cell model of limb-girdle muscular dystrophy type D2.

Poyatos-Garcia, Javier; (...); Vilchez, Juan Jesus

Article. 10.1016/j.omtn.2023.01.004. 2023

  • Open Access.

Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.

Gomez-Escribano, Ana P.; (...); Vazquez-Manrique, Rafael P.

Article. 10.15252/embr.202255556. 2023

  • Open Access.

Characterization of RAN Translation and Antisense Transcription in Primary Cell Cultures of Patients with Myotonic Dystrophy Type 1.

Koehorst, Emma; (...); Nogales-Gadea, Gisela

Article. 10.3390/jcm10235520. 2021

  • Open Access.

Deletion of exons 45 to 55 in the DMD gene: from the therapeutic perspective to the in vitro model

Poyatos-Garcia, Javier; (...); Vilchez, Juan J

Article. 10.1186/s13395-024-00353-3. 2024

  • Open Access.

DEVELOPMENT OF A CELLULAR MODEL OF ACUTE MYELOID LEUKEMIA THROUGH CRISPR/CAS 9 TECHNOLOGY

Romero, EG; (...); Zamora, JVC

Meeting Abstract. 2017

  • Open Access.

Docosahexaenoic Acid (DHA) Supplementation in a Triglyceride Form Prevents from Polyglutamine-Induced Dysfunctions in Caenorhabditis elegans

Mora, Ignasi; (...); Arola, Lluis

Article. 10.3390/ijms252312594. 2024

  • Open Access.

dsDNA, ssDNA, G-quadruplex DNA, and nucleosomal DNA electrochemical screening using canthin-6-one alkaloid-modified electrodes

Domenech-Carbo, Antonio; (...); Poupon, Erwan

Article. 10.1016/j.electacta.2013.11.025. 2014


Dystrophinopathic subjects with a specific mega-deletion of exons 45-55 in the DMD gene, as a template for CRISPR/Cas9 therapy in Duchenne muscular dystrophy

Poyatos-Garcia, J; (...); Vilchez, J

Meeting Abstract. 10.1016/j.nmd.2019.06.404. 2019

  • Open Access.

Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in Caenorhabditis elegans via aak-2/AMPK and daf-16/FOXO Signaling

Balducci, Martina; (...); Tarozzi, Andrea

Article. 10.3390/ijms252212220. 2024

  • Open Access.

IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans

Nagy AI; (...); Baylis HA

Article. 10.15252/embr.201439585. 2015

  • Open Access.

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

Guerrero-Gomez, D; (...); Miranda-Vizuete, A

Article. 10.1038/s41418-018-0270-9. 2019

  • Open Access.

Metformin intake associates with better cognitive function in patients with Huntington's disease

Hervas, David; (...); Vazquez-Manrique, Rafael P.

Article. 10.1371/journal.pone.0179283. 2017

  • Open Access.

Metformin to treat Huntington disease: a pleiotropic drug against a multi-system disorder.

Trujillo-Del Río C; (...); Vázquez-Manrique RP

Article. 10.1016/j.mad.2022.111670. 2022


Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease

Sanchis, A; (...); Vazquez-Manrique, RP

Article. 10.1038/s12276-019-0264-9. 2019

  • Open Access.

Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington's Disease

Merino, Marian; (...); Mullor, Jose L.

Article. 10.3390/ijms23168936. 2022

  • Open Access.

MODELING OF IDH2 GENE MUTATIONS IN THE CAENORHABDITIS ELEGANS ORGANISM. DEVELOPMENT OF A NEW STUDY MODEL

Gonzalez-Romero, E.; (...); Cervera-Zamora, J.

Meeting Abstract. 2021

  • Open Access.

Multiview motion tracking based on a cartesian robot to monitor Caenorhabditis elegans in standard Petri dishes.

Puchalt JC; (...); Sanchez-Salmeron, Antonio-Jose

Article. 10.1038/s41598-022-05823-6. 2022

  • Open Access.

Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease.

Vela, Marta; (...); Castro, Ana

Article. 10.1021/acschemneuro.1c00758. 2022

  • Open Access.

PCR-Based Strategy for Introducing CRISPR/Cas9 Machinery into Hematopoietic Cell Lines.

González-Romero E; (...); Vázquez-Manrique RP

Article. 10.3390/cancers15174263. 2023

  • Open Access.

Reactive Species in Huntington Disease: Are They Really the Radicals You Want to Catch?

Bono-Yagüe J; (...); Vázquez-Manrique RP

Review. 10.3390/antiox9070577. 2020

  • Open Access.

Repair of the prevalent c.2299delG mutation in the USH2A gene using CRISPR/Cas9 nucleases

Fuster-Garcia, C; (...); Aller, E

Meeting Abstract. 2018


STEROID HORMONE SIGNALING MAY REGULATE HOMEOSTASIS OF POLYQ-CONTAINING PROTEINS IN C. ELEGANS

Gomez-Escribano, A. P.; (...); Vazquez-Manrique, R.

Meeting Abstract. 10.1136/jnnp-2018-EHDN.26. 2018


Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans.

Mora I; (...); Puiggròs F

Article. 10.3390/cells12151932. 2023

  • Open Access.

Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.

Gómez-Escribano AP; (...); Vázquez-Manrique RP

Article. 10.1016/j.phrs.2020.105105. 2020

  • Open Access.

SYNERGISTIC COMBINATIONS OF METFORMIN AND SALICYLATE REDUCE POLYGLUTAMINE TOXICITY IN C. ELEGANS

Bono-Yague, Jose; (...); Vazquez-Manrique, Rafael

Meeting Abstract. 10.1136/jnnp-2018-EHDN.256. 2018


Targeted next generation sequencing for molecular diagnosis of Usher syndrome

Aparisi MJ; (...); Millán JM

Article. 10.1186/s13023-014-0168-7. 2014

  • Open Access.

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

Tourette C; (...); Neri C

Article. 10.1371/journal.pbio.1001895. 2014


TRANSCRIPTOMICAL ANALYSIS AND MODELING IN C.ELEGANS OF THE IDH2 R140 R172 MUTATION

Gonzalez-Romero, E.; (...); Cervera-Zamora, J., V

Meeting Abstract. 2019

  • Open Access.

USE OF CRISPR/CAS9 TECHNOLOGY TO MODIFY THE IDH2 GENE IN BOTH IN-VIVO AND IN-VITRO MODELS

Gonzalez Romero, E.; (...); Cervera, J., V

Meeting Abstract. 2018

  • Open Access.

USH2A gene editing by CRISPR/Cas9 system

Fuster-Garcia, C.; (...); Aller, E.

Meeting Abstract. 2016


USH2A Gene Editing Using the CRISPR System

Fuster-Garcia, C; (...); Aller, E

Article. 10.1016/j.omtn.2017.08.003. 2017

  • Open Access.

Caracterización Del Papel Regulador En La Agregación De Cuerpos De Inclusión De Poliglutaminas Del Gen Unc-1/Stomatin-Like En C. Elegans

Autor/es: Qiuyi Chen Zhang

Proyecto Fin de Carrera

Director/s: RAFAEL VÁZQUEZ MANRIQUE


Metodologías Para Ensayos Celulares In-Vitro: Aplicaciones En Investigación Básica Y Clínica

Autor/es: Oscar Bastidas García

Tesis Doctoral

Director/s: RAFAEL VÁZQUEZ MANRIQUE


Campos d'Estudi

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