Portal de investigación
BÚSQUEDA DE PATRONES METABONÓMICOS PARA LA RÁPIDA EVALUACIÓN DE LA CALIDAD DEL HÍGADO DONANTE, PREVIO AL IMPLANTE, Y LA SUBSECUENTE MONITORIZACIÓN DE SU EVOLUCIÓN POST TRASPLANTE
Datos básicos
- NumeroConcesion:
- PI11/02942
- Año inicial:
- 2012
- Año final:
- 2014
Objetivos del proyecto
FINALIZADO
Documentos
- No hay documentos
Participantes
-
Agustín Lahoz Rodríguez
Investigador Principal
Grupos
-
Hepatología experimental y Trasplante hepático
Investigador Principal
Laia Tolosa Pardo
Financiadores
Resultados del Proyecto
CELL SOURCES FOR HEPATIC CELL THERAPY
EUGENIA PAREJA IBARS, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, LAIA TOLOSA PARDO
Capítulo de un Libro. 2017
CELL-BASED THERAPEUTIC STRATEGIES FOR TREATMENT OF LIVER DISEASES.
LAIA TOLOSA PARDO, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, EUGENIA PAREJA IBARS
Capítulo de un Libro. 2017
[Liver cell therapy in the treatment of inborn errors of metabolism in children].
Abstract of Published Item. 10.1016/j.anpedi.2013.05.018. 2013
A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein ß (C/EBPß), hepatocyte nuclear factor 4a (HNF4a), and constitutive androstane receptor (CAR).
Blazquez M; (...); Bort R
Article. 10.1021/pr400085n. 2013
A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis
Garcia-Canaveras, JC; (...); Lahoz, A
Article. 10.1002/elps.201700079. 2017
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
García-Cañaveras JC; (...); Lahoz A
Article. 10.1038/srep27239. 2016
A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.
Tolosa, Laia, Gomez-Lechon, M Jose, Donato, M Teresa
Article. 10.1002/cptx.20. 2017
A Score Model for the Continuous Assessment of Early Allograft Function after Liver Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2014
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity
Article. 10.1002/lt.23990. 2015
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity Reply
Hervás D, Lahoz A
Letter. 10.1002/lt.24408. 2016
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Article. 10.1007/s00204-014-1197-7. 2014
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.
Ghergurovich JM; (...); Rabinowitz JD
Article. 10.1038/s41589-020-0533-x. 2020
Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Fernandez-Murga, ML; (...); Jover, R
Review. 10.1016/j.fct.2018.07.017. 2018
Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis
Article. 10.1016/j.taap.2016.04.007. 2016
Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Article. 10.1007/978-1-4939-6506-9_2. 2017
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.
Lahoz A; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2012.08.001. 2013
Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells
Reglero-Real N; (...); Millán J
Article. 10.1016/j.celrep.2014.08.007. 2014
Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.
Rodeiro, I; (...); Lopes, M
Article. 10.1111/jphp.13001. 2018
Baseline circulating myeloid-derived suppressor cells correlate with neutrophil-to-lymphocyte ratio and overall survival in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors
Garcia-Sanchez, J.; (...); Lahoz, A.
Meeting Abstract. 2021
Baseline circulating myeloid-derived suppressor cells subpopulations, neutrophils/lymphocytes ratio, and response to PD-1/PD-L1 inhibitor in non-small cell lung cancer patients.
SAnchez, JosE GarcIa; (...); Lahoz, Agustin
Meeting Abstract. 2020
Beneficial effects of hepatic cyclooxygenase-2 expression against cholestatic injury after common bile duct ligation in mice.
Brea, Rocio; (...); Frances, Daniel E
Article. 10.1111/liv.16004. 2024
Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development
Article. 10.1016/j.toxlet.2016.10.008. 2016
Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial.
Sowah, Solomon A.; (...); Zeller, Georg
Article. 10.1186/s13073-022-01030-0. 2022
cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants
Olivares-González L; (...); Rodrigo R
Article. 10.1371/journal.pone.0166717. 2016
Clinical Application of Pluripotent Stem Cells: An Alternative Cell-Based Therapy for Treating Liver Diseases?
Tolosa L, Pareja E, Gomez-Lechon MJ
Review. 10.1097/TP.0000000000001426. 2016
Clinical outcome of hepatocyte transplantation in four pediatric patients with inherited metabolic diseases.
Ribes-Koninckx C; (...); Castell JV
Article. 10.3727/096368912X637505. 2012
c-MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency
Prieto, Javier; (...); Torres, Josema
Article. 10.1007/s12015-021-10239-2. 2021
Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.
Clothier R; (...); Stanzel S
Article. 10.1016/j.tiv.2012.08.015. 2013
Competency of different cell models to predict human hepatotoxic drugs
Gómez-Lechón MJ; (...); Donato MT
Review. 10.1517/17425255.2014.967680. 2014
Culture and Functional Characterization of Human Hepatoma HepG2 Cells.
Donato, MT, Tolosa, L, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_5. 2015
Current status and future perspectives of hepatocyte transplantation
Review. 10.1016/j.ciresp.2013.04.010. 2014
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Tolosa, L; (...); Teresa Donato, M.
Article. 10.1007/s00204-017-2036-4. 2018
CXCR7 reactivates ERK signaling to promote resistance to EGFR kinase inhibitors in NSCLC.
Becker JH; (...); Shimamura T
Article. 10.1158/0008-5472.CAN-19-0024. 2019
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.
Gomez-Escribano, Ana P.; (...); Vazquez-Manrique, Rafael P.
Article. 10.15252/embr.202255556. 2023
Characterization of Proliferating Human Hepatocytes As a Model System for Drug Interaction Studies and Toxicity Screenings
Noerenberg, A; (...); Jover, R
Meeting Abstract. 2017
Chemokine Receptor CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Becker, J; (...); Shimamura, T
Meeting Abstract. 10.1016/j.jtho.2019.08.1478. 2019
Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool
Quintas, Guillermo; (...); Lahoz, Agustin
Article. 10.1007/s11306-011-0292-5. 2012
Chronological and Biological Age as a Response Factor to Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer
Suay, G.; (...); Juan-Vidal, O.
Meeting Abstract. 2024
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1093/toxsci/kfs083. 2012
Development of primary human NSCLC patient derived xenograft and organoids models as a precision approach to tumor treatment
Vidal, OJJ; (...); Farras, R
Meeting Abstract. 2018
Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates.
Article. 2012
Early radiological response as predictor of overall survival in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor mutations
Salvador-Coloma, C; (...); Juan, O
Article. 10.21037/jtd.2018.02.30. 2018
Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma
Pulido, I; (...); Shimamura, T
Article. 10.1158/0008-5472.CAN-20-0141. 2020
Evaluation of cytochrome P450 activities in human hepatocytes in vitro.
Gómez-Lechón MJ; (...); Donato MT
Article. 10.1007/978-1-61779-367-7_7. 2012
Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.
Rodeiro I; (...); Espinosa-Aguirre JJ
Article. 10.1016/j.fct.2012.06.032. 2012
Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1007/s00216-015-9227-8. 2016
FAMetA: a mass isotopologue-based tool for the comprehensive analysis of fatty acid metabolism.
Alcoriza-Balaguer MI; (...); Lahoz A
Article. 10.1093/bib/bbad064. 2023
General Cytotoxicity Assessment by Means of the MTT Assay.
Tolosa, L, Donato, MT, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_26. 2015
Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer's disease
Correas, Angela G.; (...); Vina, Jose
Article. 10.1016/j.redox.2024.103242. 2024
GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.
Soro-Arnáiz I; (...); Morscher RJ
Article. 10.1016/j.devcel.2024.07.015. 2024
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells
Ballester, M; (...); Bort, R
Article. 10.1038/s41598-019-54357-x. 2019
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
Donato MT, Jover R, Gómez-Lechón MJ
Article. 2013
Hepatocyte transplantation program: Lessons learned and future strategies
Review. 10.3748/wjg.v22.i2.874. 2016
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.
Article. 10.1007/s00204-013-1012-x. 2013
High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.
Donato MT; (...); Gómez-Lechón MJ
Article. 10.1177/1087057111427586. 2012
High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Article. 10.1007/s00204-014-1334-3. 2015
High-content screening technology for studying drug-induced hepatotoxicity in cell models
Tolosa L, Gómez-Lechón MJ, Donato MT
Review. 10.1007/s00204-015-1503-z. 2015
Human hepatocyte transplantation in patients with hepatic failure awaiting a graft.
Article. 10.1159/000351332. 2013
Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening
Review. 10.1007/s00204-016-1756-1. 2016
Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1002/lt.24121. 2015
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing
Article. 10.1093/toxsci/kfw078. 2016
Identification of a Novel Synthetic Lethal Vulnerability in Non-Small Cell Lung Cancer by Co-Targeting TMPRSS4 and DDR1
Redin, E; (...); Calvo, A
Meeting Abstract. 10.1016/j.jtho.2019.08.1485. 2019
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1
Villalba, Maria; (...); Calvo, Alfonso
Article. 10.1038/s41598-019-51066-3. 2019
Immune checkpoint inhibitors as first-line treatment for brain metastases in stage IV NSCLC patients without driver mutations
Suay, Guillermo; (...); Lahoz, Agustin
Review. 10.1016/j.canlet.2024.217317. 2024
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure
Bolonio, M.; (...); Tolosa, L.
Meeting Abstract. 2019
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.
Article. 10.1016/j.jcyt.2019.12.005. 2020
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.
Puppi J; (...); Dhawan A
Article. 10.3727/096368911X566208. 2012
In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.
Pérez CL; (...); Rodeiro I
Article. 10.1515/dmpt-2017-0020. 2017
In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS
Carretero, A; (...); Lahoz, A
Article. 10.1007/s00216-014-7983-5. 2014
Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Review. 10.21037/atm.2020.02.164. 2020
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten MJ; (...); Kleinjans JC
Article. 10.1016/j.tox.2014.06.007. 2014
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten, Marlon J. A.; (...); van Delft, Joost H. M.
Article. 10.1016/j.toxlet.2013.05.312. 2013
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc
Magudia, Kirti, Lahoz, Aurelia, Hall, Alan
Article. 10.1083/jcb.201202108. 2012
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8(+) T cell stemness and antitumor immunity
Hermans, D; (...); Leonard, WJ
Article. 10.1073/pnas.1920413117. 2020
LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1002/elps.201500095. 2015
LipidMS 3.0: an R-package and a web-based tool for LC-MS/MS data processing and lipid annotation.
Alcoriza-Balaguer MI; (...); Lahoz, Agustin
Article. 10.1093/bioinformatics/btac581. 2022
LipidMS: An R Package for Lipid Annotation in Untargeted Liquid Chromatography-Data Independent Acquisition-Mass Spectrometry Lipidomics
Alcoriza-Balaguer, MI; (...); Lahoz, A
Article. 10.1021/acs.analchem.8b03409. 2019
Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.
Tolosa, L; (...); Donato, MT
Article. 10.1007/s00204-018-2349-y. 2019
Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection
Caron, J; (...); Dubart-Kupperschmitt, A
Meeting Abstract. 10.1016/S0168-8278(18)30382-9. 2018
Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
Caron J; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-019-1342-6. 2019
Mammalian cell metabolomics: experimental design and sample preparation.
León Z; (...); Lahoz A
Article. 10.1002/elps.201200605. 2013
Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.
Rodeiro I; (...); Teresa Donato M
Article. 10.1002/ptr.4782. 2013
Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1002/jat.3277. 2016
Metabolic vulnerabilities of mesenchymal-like EGFR-mutant NSCLC cells with acquired resistance to tyrosine kinase inhibitors
Pulido, I; (...); Carretero, J
Meeting Abstract. 10.1158/1538-7445.AM2018-LB-099. 2018
Metabolomic Analysis of the Effect of Postnatal Hypoxia on the Retina in a Newly Born Piglet Model.
Solberg R; (...); Quintás G
Article. 10.1371/journal.pone.0066540. 2013
Metabolomic changes in the rat retina after optic nerve crush.
Agudo-Barriuso M; (...); Mullor JL
Article. 10.1167/iovs.12-11451. 2013
Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction
Cortes M; (...); Lahoz A
Article. 10.1016/j.jhep.2014.04.023. 2014
Metabolomics of Plasma in XLH Patients with Arterial Hypertension: New Insights into the Underlying Mechanisms
Lopez-Romero, Luis Carlos; (...); Hernandez-Jaras, Julio
Article. 10.3390/ijms25063545. 2024
Methods for analysis of specific DNA methylation status.
Pajares MJ; (...); Sandoval J
Article. 10.1016/j.ymeth.2020.06.021. 2020
Mild Muscle Mitochondrial Fusion Distress Extends Drosophila Lifespan through an Early and Systemic Metabolome Reorganization.
Tapia A; (...); Galindo MI
Article. 10.3390/ijms222212133. 2021
miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.
Pérez-Andreu V; (...); Martínez C
Article. 10.2119/molmed.2012.00062. 2013
miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review.
García-Giménez JL; (...); Mena-Molla S
Article. 10.3390/ijms25031737. 2024
Modelos Celulares hepáticos avanzados para el estudio preclíico del metabolismo y la hepatotoxicdad de fármacos.
MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER
Article. 2017
Modulation of biotransformation and elimination systems by BM-21, an aqueous ethanolic extract from Thalassia testudinum, and thalassiolin B on human hepatocytes
Rodeiro, Idania; (...); Teresa Donato, Maria
Article. 10.1016/j.jff.2011.10.002. 2012
Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1111/jphp.12071. 2013
Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.3727/096368913X669743. 2014
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease
Lopez-Riera, M; (...); Jover, R
Article. 10.3389/fpahr.2017.00003. 2017
Non-Invasive Infections Diagnosis in Lung Transplant Recipients in Exhaled Breath Condensate
Ibanez-Martinez, E.; (...); Sole-Jover, A.
Meeting Abstract. 2021
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Ringel, AE; (...); Haigis, MC
Article. 10.1016/j.cell.2020.11.009. 2020
PLEIOTROPIC EFFECT OF MIR-146A CAUSES PLATELET HYPERREACTIVITY AND THROMBOSIS THROUGH METABOLIC ICA REPROGRAMMING
Sonia, Aguila; (...); Constantino, Martinez
Meeting Abstract. 2021
Pre-diagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma.
Stepien, Magdalena; (...); Jenab, Mazda
Article. 10.1002/ijc.33885. 2022
Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study.
Kühn T; (...); Kaaks R
Article. 10.1093/jnci/djz166. 2020
Predicting drug-induced cholestasis: preclinical models
Petrov, PD; (...); Jover, R
Review. 10.1080/17425255.2018.1487399. 2018
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Godoy P; (...); Hengstler JG
Article. 10.1007/s00204-013-1078-5. 2013
Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.
Fourrier A; (...); Nguyen TH
Article. 10.1111/xen.12544. 2020
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial
Review. 2021
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial.
Article. 10.1016/j.aca.2020.12.025. 2021
Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity.
Canovas-Cervera, Irene; (...); Mena-Molla, Salvador
Article. 10.1016/bs.ircmb.2024.08.002. 2025
RpeakChrom: Novel R package for the automated characterization and optimization of column efficiency in high-performance liquid chromatography analysis
Peris-Diaz, MD; (...); Lahoz, A
Article. 10.1002/elps.201700180. 2017
Sex Differences in the Efficacy of Immune Checkpoint Inhibitors in Neoadjuvant Therapy of Non-Small Cell Lung Cancer: A Meta-Analysis
Suay, Guillermo; (...); Juan-Vidal, Oscar
Review. 10.3390/cancers15184433. 2023
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia.
García-Cañaveras JC; (...); Rabinowitz JD
Article. 10.1038/s41375-020-0845-6. 2020
Sparse N-way partial least squares by L1-penalization
Hervas, D; (...); Ferrer, A
Article. 10.1016/j.chemolab.2019.01.004. 2019
Sparse N-way partial least squares with R package sNPLS
Hervas, D.; (...); Ferrer, A.
Article. 10.1016/j.chemolab.2018.06.005. 2018
Starkeya nomas sp. nov., a prosthecate and budding bacterium isolated from an immunocompromized patient.
Sahuquillo-Arce JM; (...); López-Hontangas JL
Article. 10.1099/ijsem.0.005805. 2023
STEROID HORMONE SIGNALING MAY REGULATE HOMEOSTASIS OF POLYQ-CONTAINING PROTEINS IN C. ELEGANS
Gomez-Escribano, A. P.; (...); Vazquez-Manrique, R.
Meeting Abstract. 10.1136/jnnp-2018-EHDN.26. 2018
Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH2.
Somlai C; (...); Enriz RD
Article. 10.1016/j.bmcl.2012.05.045. 2012
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.
García-Cañaveras JC; (...); Lahoz A
Article. 10.1194/jlr.D028803. 2012
Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity
Garcia, Ana Garcia; (...); Sanchez-Arevalo Lobo, Victor Javier
Article. 10.1038/s41467-025-56894-8. 2025
The Potential Role of Efficacy and Safety Evaluation of N-Acetylcysteine Administration During Liver Procurement. The NAC-400 Single Center Randomized Controlled Trial
Gomez-Gavara, C; (...); Lopez-Andujar, R
Article. 10.1097/TP.0000000000003487. 2021
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
Fernández-Álvarez S; (...); Beraza N
Article. 10.1038/labinvest.2014.151. 2015
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer
Palanca-Ballester, Cora; (...); Sandoval, Juan
Article. 10.1186/s13148-022-01334-3. 2022
Transplantation of hESC-derived hepatocytes protects mice from liver injury
Tolosa L; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-015-0227-6. 2015
Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers
Review. 10.3390/cancers13133230. 2021
Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species.
García-Cañaveras JC, Donato MT, Lahoz A
Article. 10.1007/978-1-4939-1258-2_15. 2014
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2011.11.008. 2012
Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1080/17425255.2017.1238459. 2017
Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies
Donato, MT, Gomez-Lechon, MJ, Tolosa, L
Review. 10.1080/17460441.2017.1271784. 2017
Xenobiotic metabolism in differentiated human bronchial epithelial cells
Boei JJWA; (...); Vrieling, H
Article. 10.1007/s00204-016-1868-7. 2017
Ensayo Multiparamétrico In Vitro Para La Evaluación De La Hepatotoxicidad Mitocondrial De Fármacos
Autor/es: Antonio Carmona Serrano
Proyecto Fin de Carrera
Director/es: LAIA TOLOSA PARDO; MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER
Campos de Estudio
Cita
BÚSQUEDA DE PATRONES METABONÓMICOS PARA LA RÁPIDA EVALUACIÓN DE LA CALIDAD DEL HÍGADO DONANTE, PREVIO AL IMPLANTE, Y LA SUBSECUENTE MONITORIZACIÓN DE SU EVOLUCIÓN POST TRASPLANTE. (PI11/02942). FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; INSTITUTO DE SALUD CARLOS III. 2012-2014. IP:AGUSTÍN LAHOZ RODRÍGUEZ.