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CONTRATO POSTDOCTORAL DE INVESTIGACION SARA BORELL

Datos básicos

Protocolo:
CD11/00007
EUDRACT:
NCT:
Centro:
Año de incio:
2012
Año de finalización:
2015
RRHH NACIONAL Finan. Competitiva Pública

Objetivos del proyecto

FINALIZADO

Documentos

  • No hay documentos

Participantes

Grupos

Financiadores - Promotores

FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
INSTITUTO DE SALUD CARLOS III

Resultados del Ensayo Clínico

CELL SOURCES FOR HEPATIC CELL THERAPY

EUGENIA PAREJA IBARS, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, LAIA TOLOSA PARDO

Capítulo de un Libro. 2017


CELL-BASED THERAPEUTIC STRATEGIES FOR TREATMENT OF LIVER DISEASES.

LAIA TOLOSA PARDO, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, EUGENIA PAREJA IBARS

Capítulo de un Libro. 2017


[Liver cell therapy in the treatment of inborn errors of metabolism in children].

Pareja E; (...); Mir J

Abstract of Published Item. 10.1016/j.anpedi.2013.05.018. 2013


A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.

Tolosa, Laia, Gomez-Lechon, M Jose, Donato, M Teresa

Article. 10.1002/cptx.20. 2017


A simple transcriptomic signature able to predict drug-induced hepatic steatosis

Benet M; (...); Jover R

Article. 10.1007/s00204-014-1197-7. 2014


Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

Fernandez-Murga, ML; (...); Jover, R

Review. 10.1016/j.fct.2018.07.017. 2018


Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

Tolosa L; (...); Donato MT

Article. 10.1016/j.taap.2016.04.007. 2016


Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.

Pareja, E, Gomez-Lechon, MJ, Tolosa, L

Article. 10.1007/978-1-4939-6506-9_2. 2017


An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.

Lahoz A; (...); Gómez-Lechón MJ

Article. 10.1016/j.tiv.2012.08.001. 2013


Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells

Reglero-Real N; (...); Millán J

Article. 10.1016/j.celrep.2014.08.007. 2014

  • Open Access.

Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.

Rodeiro, I; (...); Lopes, M

Article. 10.1111/jphp.13001. 2018

  • Open Access.

Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development

Donato MT; (...); Jover R

Article. 10.1016/j.toxlet.2016.10.008. 2016


Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons.

Lladó J, Tolosa L, Olmos G

Article. 10.3389/fncel.2013.00181. 2013

  • Open Access.

Clinical Application of Pluripotent Stem Cells: An Alternative Cell-Based Therapy for Treating Liver Diseases?

Tolosa L, Pareja E, Gomez-Lechon MJ

Review. 10.1097/TP.0000000000001426. 2016


Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.

Clothier R; (...); Stanzel S

Article. 10.1016/j.tiv.2012.08.015. 2013


Competency of different cell models to predict human hepatotoxic drugs

Gómez-Lechón MJ; (...); Donato MT

Review. 10.1517/17425255.2014.967680. 2014


Culture and Functional Characterization of Human Hepatoma HepG2 Cells.

Donato, MT, Tolosa, L, Gomez-Lechon, MJ

Article. 10.1007/978-1-4939-2074-7_5. 2015


Current status and future perspectives of hepatocyte transplantation

Pareja E; (...); Mir J

Review. 10.1016/j.ciresp.2013.04.010. 2014


Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

Tolosa, L; (...); Teresa Donato, M.

Article. 10.1007/s00204-017-2036-4. 2018

  • Open Access.

Characterization of Proliferating Human Hepatocytes As a Model System for Drug Interaction Studies and Toxicity Screenings

Noerenberg, A; (...); Jover, R

Meeting Abstract. 2017


Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.

Tolosa L; (...); Gómez-Lechón MJ

Article. 10.1093/toxsci/kfs083. 2012


Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.

Aranda A; (...); Gombau L

Article. 10.1016/j.tiv.2013.01.016. 2013


Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates.

Donato MT, Gómez-Lechón MJ

Article. 2012


Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.

Rodeiro I; (...); Espinosa-Aguirre JJ

Article. 10.1016/j.fct.2012.06.032. 2012


General Cytotoxicity Assessment by Means of the MTT Assay.

Tolosa, L, Donato, MT, Gomez-Lechon, MJ

Article. 10.1007/978-1-4939-2074-7_26. 2015


Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

Donato MT, Jover R, Gómez-Lechón MJ

Article. 2013


Hepatocyte transplantation program: Lessons learned and future strategies

Ibars EP; (...); Mir J

Review. 10.3748/wjg.v22.i2.874. 2016

  • Open Access.

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

Tolosa L; (...); Donato MT

Article. 10.1007/s00204-013-1012-x. 2013


High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.

Donato MT; (...); Gómez-Lechón MJ

Article. 10.1177/1087057111427586. 2012


High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins

Tolosa L; (...); Donato MT

Article. 10.1007/s00204-014-1334-3. 2015


High-content screening technology for studying drug-induced hepatotoxicity in cell models

Tolosa L, Gómez-Lechón MJ, Donato MT

Review. 10.1007/s00204-015-1503-z. 2015


Human hepatocyte transplantation in patients with hepatic failure awaiting a graft.

Pareja E; (...); Mir J

Article. 10.1159/000351332. 2013


Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening

Gomez-Lechon, MJ, Tolosa, L

Review. 10.1007/s00204-016-1756-1. 2016


Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat

Tolosa L; (...); Gómez-Lechón MJ

Article. 10.1002/lt.24121. 2015


Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing

Tolosa L; (...); Jover R

Article. 10.1093/toxsci/kfw078. 2016


Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure

Bolonio, M.; (...); Tolosa, L.

Meeting Abstract. 2019


Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.

Donato MT; (...); Tolosa L

Article. 10.1016/j.jcyt.2019.12.005. 2020


In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.

Pérez CL; (...); Rodeiro I

Article. 10.1515/dmpt-2017-0020. 2017


In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS

Carretero, A; (...); Lahoz, A

Article. 10.1007/s00216-014-7983-5. 2014


Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint

Pareja, E, Gomez-Lechon, MJ, Tolosa, L

Review. 10.21037/atm.2020.02.164. 2020

  • Open Access.

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells

García-Cañaveras JC; (...); Lahoz A

Article. 10.1002/elps.201500095. 2015


Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.

Tolosa, L; (...); Donato, MT

Article. 10.1007/s00204-018-2349-y. 2019

  • Open Access.

Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Caron, J; (...); Dubart-Kupperschmitt, A

Meeting Abstract. 10.1016/S0168-8278(18)30382-9. 2018


Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.

Caron J; (...); Dubart-Kupperschmitt A

Article. 10.1186/s13287-019-1342-6. 2019

  • Open Access.

Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.

Rodeiro I; (...); Teresa Donato M

Article. 10.1002/ptr.4782. 2013


Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs

Gomez-Lechon, MJ, Tolosa, L, Donato, MT

Review. 10.1002/jat.3277. 2016


miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.

Pérez-Andreu V; (...); Martínez C

Article. 10.2119/molmed.2012.00062. 2013


Modelos Celulares hepáticos avanzados para el estudio preclíico del metabolismo y la hepatotoxicdad de fármacos.

MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER

Article. 2017


Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells.

Tolosa L; (...); Gómez-Lechón MJ

Article. 10.1111/jphp.12071. 2013


Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation

Tolosa L; (...); Gómez-Lechón MJ

Article. 10.3727/096368913X669743. 2014


New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

Lopez-Riera, M; (...); Jover, R

Article. 10.3389/fpahr.2017.00003. 2017

  • Open Access.

Predicting drug-induced cholestasis: preclinical models

Petrov, PD; (...); Jover, R

Review. 10.1080/17425255.2018.1487399. 2018


Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P; (...); Hengstler JG

Article. 10.1007/s00204-013-1078-5. 2013


Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.

Fourrier A; (...); Nguyen TH

Article. 10.1111/xen.12544. 2020

  • Open Access.

Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH2.

Somlai C; (...); Enriz RD

Article. 10.1016/j.bmcl.2012.05.045. 2012


Transplantation of hESC-derived hepatocytes protects mice from liver injury

Tolosa L; (...); Dubart-Kupperschmitt A

Article. 10.1186/s13287-015-0227-6. 2015

  • Open Access.

Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.

Tolosa L; (...); Gómez-Lechón MJ

Article. 10.1016/j.tiv.2011.11.008. 2012


Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing

Gomez-Lechon, MJ, Tolosa, L, Donato, MT

Review. 10.1080/17425255.2017.1238459. 2017


Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies

Donato, MT, Gomez-Lechon, MJ, Tolosa, L

Review. 10.1080/17460441.2017.1271784. 2017


Ensayo Multiparamétrico In Vitro Para La Evaluación De La Hepatotoxicidad Mitocondrial De Fármacos

Autor/es: Antonio Carmona Serrano

Proyecto Fin de Carrera

Director/es: LAIA TOLOSA PARDO; MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER


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