Portal de recerca
A SEARCH FOR A MULTIPARAMETRIC ASSESSMENT OF GRAFT PERFORMANCE PRIOR TO LIVER TRANSPLANT
Dades bàsiques
- Protocol:
- CP08/00125 (MIGUEL SERVET)
- EURDRACT:
- NCT:
- Centre:
- Any inici:
- 2009
- Any de finalització:
- 2014
Objectius del projecte
FAVORABLE
Documents
- No hi ha documents
Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein ß (C/EBPß), hepatocyte nuclear factor 4a (HNF4a), and constitutive androstane receptor (CAR).
Blazquez M; (...); Bort R
Article. 10.1021/pr400085n. 2013
A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations
Garcia-Canaveras, Juan C.; (...); Lahoz, Agustin
Article. 10.1021/pr200629p. 2011
A New Score System To Classify Liver Graft Functionality after Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2011
A Score Model for the Continuous Assessment of Early Allograft Function after Liver Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2014
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Article. 10.1007/s00204-014-1197-7. 2014
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.
Lahoz A; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2012.08.001. 2013
Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes
Mathijs, Karen; (...); van Delft, Joost H. M.
Article. 10.1124/dmd.108.025775. 2009
CCAAT/Enhancer-binding Protein alpha (C/EBP alpha) and Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL
Benet, Marta; (...); Jover, Ramiro
Article. 10.1074/jbc.M110.118364. 2010
Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool
Quintas, Guillermo; (...); Lahoz, Agustin
Article. 10.1007/s11306-011-0292-5. 2012
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1093/toxsci/kfs083. 2012
Evaluation of cytochrome P450 activities in human hepatocytes in vitro.
Gómez-Lechón MJ; (...); Donato MT
Article. 10.1007/978-1-61779-367-7_7. 2012
Exploring Mass Spectrometry Suitability to Examine Human Liver Graft Metabonomic Profiles
Cortes, M.; (...); Lahoz, A.
Article. 10.1016/j.transproceed.2010.07.049. 2010
Functional Characterization of Hepatocytes for Cell Transplantation: Customized Cell Preparation for Each Receptor
Bonora-Centelles, A.; (...); Gomez-Lechon, M. J.
Article. 10.3727/096368909X474267. 2010
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Yildirimman, Reha; (...); Herwig, Ralf
Article. 10.1093/toxsci/kfr225. 2011
In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs
Gomez-Lechon, M. J.; (...); Donato, M. T.
Article. 10.2174/138161210791208910. 2010
In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS
Carretero, A; (...); Lahoz, A
Article. 10.1007/s00216-014-7983-5. 2014
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten MJ; (...); Kleinjans JC
Article. 10.1016/j.tox.2014.06.007. 2014
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten, Marlon J. A.; (...); van Delft, Joost H. M.
Article. 10.1016/j.toxlet.2013.05.312. 2013
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc
Magudia, Kirti, Lahoz, Aurelia, Hall, Alan
Article. 10.1083/jcb.201202108. 2012
Mammalian cell metabolomics: experimental design and sample preparation.
León Z; (...); Lahoz A
Article. 10.1002/elps.201200605. 2013
Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
Teresa Donato, M.; (...); Lahoz, Agustin
Article. 10.1124/dmd.110.033605. 2010
Metabolomic Analysis of the Effect of Postnatal Hypoxia on the Retina in a Newly Born Piglet Model.
Solberg R; (...); Quintás G
Article. 10.1371/journal.pone.0066540. 2013
Metabolomic changes in the rat retina after optic nerve crush.
Agudo-Barriuso M; (...); Mullor JL
Article. 10.1167/iovs.12-11451. 2013
Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction
Cortes M; (...); Lahoz A
Article. 10.1016/j.jhep.2014.04.023. 2014
Novel antihypertensive hexa- and heptapeptides with ACE-inhibiting properties: From the in vitro ACE assay to the spontaneously hypertensive rat
Ruiz-Gimenez, Pedro; (...); Salom, Juan B.
Article. 10.1016/j.peptides.2011.05.013. 2011
Searching for Metabolic Biomarkers as a Probe of Liver Graft Function To Assess Organ Quality Prior to Its Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2011
Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells
Antherieu, Sebastien; (...); Guillouzo, Andre
Article. 10.1124/dmd.109.030197. 2010
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.
García-Cañaveras JC; (...); Lahoz A
Article. 10.1194/jlr.D028803. 2012
Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species.
García-Cañaveras JC, Donato MT, Lahoz A
Article. 10.1007/978-1-4939-1258-2_15. 2014
Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies
Teresa Donato, M.; (...); Lahoz, Agustin
Article. 10.1007/s00216-009-3441-1. 2010