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  3. A Phase 2, Open-Label, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease.

A Phase 2, Open-Label, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease.

Datos básicos

Protocolo:
INCA 34176-254
EUDRACT:
NCT:
Centro:
HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
Año de incio:
2025
Año de finalización:
ENSAYO CLÍNICO

Documentos

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Participantes

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Grupos

Financiadores - Promotores

INCYTE CORPORATION

Resultados del Ensayo Clínico

[Translated article] Knowledge of biological therapy in patients with immune-mediated diseases. BIOINFO study.

Segui-Solanes, Carlos; (...); Borras-Blasco, Joaquin

Article. 10.1016/j.farma.2024.08.002. 2024

  • Open Access.

[Translated article] New challenges in advanced therapies.

Megías-Vericat JE; (...); Poveda Andrés JL

Article. 10.1016/j.farma.2024.05.001. 2024

  • Open Access.

[Translated article] Pharmacokinetic-guided switching from standard half-life factor VIII to extended half-life pegylated factor VIII in haemophilia A therapy in clinical practice.

Chovi-Trull, Maria; (...); Andres, Jose Luis Poveda

Article. 10.1016/j.farma.2024.12.007. 2025


Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia With Myelodysplasia-Related Genetic Features: Relevance of the Genetic Underlying Category. A Retrospective Analysis on Behalf of the Acute Leukemia Working Party of the EBMT.

Esteve, Jordi; (...); Ciceri, Fabio

Article. 10.1002/ajh.27647. 2025


Allogeneic stem cell transplantation in de novo core-binding factor acute myeloid leukemia in first complete remission: data from the EBMT.

Al Hamed R; (...); Mohty M

Article. 10.1038/s41409-024-02373-5. 2024


ALLOGENEIC TRANSPLANTATION FOR PATIENTS WITH ACUTE MYELOID LEUKEMIA WITH MYELODYSPLASIA-RELATED FEATURES AS PER THE INTERNATIONAL CONSENSUS CLASSIFICATION (ICC) 2022: FROM THE ALWP OF THE EBMT

Nagler, Arnon; (...); Mohty, Mohamad

Meeting Abstract. 2024


Anti-CD19 CAR-T cell therapy in elderly patients: multicentric real-world experience from GETH-TC/GELTAMO.

Bailen, Rebeca; (...); Kwon, Mi

Article. 10.1016/j.jtct.2024.06.022. 2024

  • Open Access.

Are any specific respiratory viruses more severe than others in recipients of allogeneic stem cell transplantation? A focus on lower respiratory tract disease.

Pérez A; (...); Piñana JL

Article. 10.1038/s41409-024-02304-4. 2024


Assessment of the Immunodeficiency Scoring Index for predicting outcomes after Respiratory Syncytial Virus infection in Allogeneic Stem Cell Transplant recipients.: ISI performance for RVS infections after allo-HCT.

Mico-Cerda, Mireia; (...); Pinana, Jose Luis

Article. 10.1016/j.jtct.2025.02.012. 2025


Central nervous system manifestations in acute and chronic graft-versus-host disease.

Lambert N; (...); Maquet P

Article. 10.1093/brain/awae340. 2024

  • Open Access.

Community-Acquired Respiratory Virus Infections: A Threat to Long-Term survivors after Allogeneic Stem Cell Transplant?

Pinana, Jose Luis; (...); Solano, Carlos

Article. 10.1093/cid/ciae602. 2024

  • Open Access.

COMPARISON OF THREE STRATEGIES OF GVHD PROPHYLAXIS AFTER T-CELL REPLETE HAPLOIDENTICAL HEMATOPOIETIC TRANSPLANTATION: TACROLIMUS vs. CALCINEURIN INHIBITORS-MMF vs. SIROLIMUS-MMF.

Esquirol A; (...); Martino R

Article. 10.1016/j.jtct.2024.07.027. 2024

  • Open Access.

CONDITIONING INTENSITY IN STEM CELL TRANSPLANTATION WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE FOR ACUTE MYELOID LEUKEMIA: A STUDY FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT

Sanz, Jaime; (...); Ciceri, Fabio

Meeting Abstract. 2024


Cost-effectiveness and cost-utility analysis of haemate-P versus other von willebrand disease treatments in Spain.

Megias-Vericat, Juan E; (...); Yan, Songkai

Article. 10.1080/13696998.2025.2474886. 2025


Chimeric antigen receptor T-cell therapy outcomes in T cell/histiocyte-rich large B-cell lymphoma and subsequent treatment strategies after disease progression: A GELTAMO/GETH study.

Bastos-Oreiro, Mariana; (...); Barba, Pere

Article. 10.1002/hem3.70077. 2025


Development and testing of a mobile app for systematic collection of patient-reported outcomes (PROs) in patients with hemophilia.

Megias-Vericat, J E; (...); Poveda Andres, J L

Letter. 10.1016/j.thromres.2024.109122. 2024


Effect of Consolidation with Allogeneic Hematopoietic Cell Transplant Versus No Consolidation in Patients with Non-Hodgkin Lymphomas Treated with Bispecific Antibodies

Losi, Giulia; (...); Mussetti, Alberto

Meeting Abstract. 10.1182/blood-2024-202933. 2024


Frequency and Impact of Somatic Mutations Alone or in Combination on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Large Study on Behalf of the EBMT Acute Leukemia Working Party

Bazarbachi, Ali; (...); Mohty, Mohamad

Meeting Abstract. 10.1182/blood-2024-204672. 2024


FREQUENCY AND IMPACT OF SOMATIC MUTATIONS ON OUTCOMES OF ACUTE MYELOID LEUKEMIA PATIENTS RECEIVING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: FROM THE EBMT ACUTE LEUKEMIA WORKING PARTY

Bazarbachi, Ali; (...); Mohty, Mohamad

Meeting Abstract. 2024


Gastric Bleeding in Stem Cell Transplantation: A Focus on Gastric Vascular Ectasia Under Post-Transplant Cyclophosphamide, Sirolimus, and Mycophenolate Mofetil Prophylaxis.

Eirís J; (...); Sanz J

Article. 10.1016/j.jtct.2024.10.009. 2024

  • Open Access.

Higher survival following transplantation with a mismatched unrelated donor with posttransplant cyclophosphamide-based graft-versus-host disease prophylaxis than with double unit umbilical cord blood in patients with acute myeloid leukemia in first complete remission: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

Baron, Frederic; (...); Ciceri, Fabio

Article. 10.1002/ajh.27466. 2024

  • Open Access.

IDIOPATHIC UPPER GASTROINTESTINAL BLEEDING AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: AN UNPRECEDENTED COMPLICATION

Eiris, Juan; (...); Balaguer-Rosello, Aitana

Meeting Abstract. 2024


Imaging features and clinical data-based network analysis of CAR-T treated B- cell lymphoma patients in relation to their TP53 mutation status

Estepa-Fernandez, A.; (...); Alberich-Bayarri, A.

Meeting Abstract. 2024


Incidence, risk factors and therapy response of acute graft-versus-host disease after myeloablative hematopoietic stem cell transplantation with posttransplant cyclophosphamide.

Asensi Cantó P; (...); Sanz J

Article. 10.1038/s41409-024-02391-3. 2024

  • Open Access.

Incidence, risk factors, and outcomes of BK hemorrhagic cystitis in hematopoietic stem cell transplantation from HLA-matched and haploidentical donors with post-transplant cyclophosphamide.

Chorao, Pedro; (...); Sanz, Jaime

Article. 10.1016/j.jtct.2024.12.006. 2024

  • Open Access.

Late Adverse Events After Chimeric Antigen Receptor T-Cell Therapy for Patients With Aggressive B-Cell Non-Hodgkin Lymphoma

Camacho-Arteaga, Lina; (...); Agusti, Antonia

Article. 10.1001/jamanetworkopen.2024.61683. 2025


Longitudinal outcome over four decades of allogeneic stem cell transplantation: a single center experience.

Sanz, Miguel Angel; (...); Sanz, Jaime

Article. 10.1038/s41409-024-02319-x. 2024

  • Open Access.

MATCHED RELATED VERSUS MATCHED UNRELATED VERSUS HAPLOIDENTICAL DONORS IN FLT3-ITD + AML PATIENTS IN CR1: A STUDY FROM THE EBMT ACUTE LEUKEMIA WORKING PARTY

Brissot, Eolia; (...); Ciceri, Fabio

Meeting Abstract. 2024


Mental, emotional and social dimensions of quality of life and their relationship with physical and functional status in adults with haemophilia.

Rodríguez MA; (...); Chimeno-Hernández A

Article. 10.1016/j.thromres.2024.109181. 2024

  • Open Access.

Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases

Artacho, Alejandro; (...); Ubeda, Carles

Article. 10.1186/s40168-024-01948-0. 2024

  • Open Access.

New challenges of advanced therapies.

Megías-Vericat JE; (...); Poveda Andrés JL

Article. 10.1016/j.farma.2023.11.008. 2024

  • Open Access.

OLD MATCHED SIBLING DONOR VERSUS YOUNG HAPLOIDENTICAL DONOR FOR ELDERLY PATIENTS WITH ACUTE MYELOID LEUKEMIA TRANSPLANTED IN FIRST REMISSION

Poire, Xavier; (...); Ciceri, Fabio

Meeting Abstract. 2024


Older MRD vs. younger MUD in patients older than 50 years with AML in remission using post-transplant cyclophosphamide.

Piemontese S; (...); Ciceri F

Article. 10.1038/s41375-024-02359-8. 2024

  • Open Access.

Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review.

Ballesta-Lopez, Octavio; (...); Poveda-Andres, Jose Luis

Article. 10.3390/ijms26041760. 2025

  • Open Access.

POOLED FECAL ALLOGENEIC MICROBIOTHERAPY FOR REFRACTORY GASTROINTESTINAL ACUTE GRAFT-VERSUSHOST DISEASE: RESULTS FROM THE EARLY ACCESS PROGRAM IN EUROPE

Malard, Florent; (...); Mohty, Mohamad

Meeting Abstract. 2024

  • Open Access.

Post-Transplant Cyclophosphamide Versus Antithymocyte Globulin in Haploidentical Transplantation for Relapsed/Refractory Acute Myeloid Leukemia: A Study from the Acute Leukemia Working Party of the EBMT

Battipaglia, Giorgia; (...); Ciceri, Fabio

Meeting Abstract. 10.1182/blood-2024-207391. 2024


Posttransplant cyclophosphamide versus anti-thymocyte globulin versus combination for graft-versus-host disease prevention in haploidentical transplantation for adult acute myeloid leukemia: A report from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party.

Bazarbachi, Abdul-Hamid; (...); Mohty, Mohamad

Article. 10.1002/cncr.35365. 2024

  • Open Access.

Predicting survival, neurotoxicity and response in B-cell lymphoma patients treated with CAR-T therapy using an imaging features-based model

Ferrer-Lores, Blanca; (...); Alberich-Bayarri, Angel

Article. 10.1186/s13550-024-01172-9. 2024

  • Open Access.

PTCy vs CNI-based GVHD prophylaxis in HLA-matched transplants for Hodgkin lymphoma: a study of the LWP of the EBMT.

Montoro J; (...); Glass B

Article. 10.1182/bloodadvances.2024013328. 2024

  • Open Access.

Ruxolitinib for foreign body reaction to silicone in a patient with chronic graft-versus-host disease.

Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael

Letter. 10.1111/ijd.17365. 2024

  • Open Access.

RUXOLITINIB IN ACUTE AND CHRONIC GRAFT-VERSUS RECEPTOR DISEASE: LONG-TERM REAL-LIFE EXPERIENCE IN A MULTI-CENTRE STUDY IN PEDIATRIC POPULATION

Escamilla Gomez, Virginia; (...); Garcia Gutierrez, Valentin

Meeting Abstract. 2024


RUXOLITINIB IN ACUTE AND CHRONIC GRAFT-VERSUS-RECEPTOR DISEASE: LONG-TERM REAL-LIFE EXPERIENCE IN A MULTI-CENTRE STUDY

Escamilla Gomez, Virginia; (...); Perez-Simon, Jose Antonio

Meeting Abstract. 2024


Selective IgA Deficiency and Blood Component Transfusion: In Search of the Lost Evidence

Solves, Pilar; (...); de la Rubia, Javier

Article. 10.3390/hemato5020009. 2024

  • Open Access.

Total body irradiation versus thiotepa/busulfan-based conditioning regimens for myeloablative allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia.

Mora E; (...); Sanz J

Article. 10.1038/s41409-024-02298-z. 2024


Toxic-metabolic encephalopathy induced by metronidazole and disulfiram: classics never die.

Chovi-Trull, Maria; (...); Poveda-Andres, Jose Luis

Article. 10.1136/ejhpharm-2024-004184. 2024


TRENDS IN THE USE OF HEMATOPOIETIC CELL TRANSPLANTATION FOR ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A REPORT FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT

Giebel, Sebastian; (...); Ciceri, Fabio

Meeting Abstract. 10.1007/s00277-019-03771-2. 2024

  • Open Access.

UNRELATED DONOR SELECTION FOR STEM CELL TRANSPLANT USING POST-TRANSPLANT CYCLOPHOSPHAMIDE FOR ACUTE MYELOID LEUKEMIA: A STUDY FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT

Sanz, Jaime; (...); Ciceri, Fabio

Meeting Abstract. 2024


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