Portal de investigación
- Inicio
- Proyectos y Estudios
- Estudio aleatorizado, doble ciego, multicéntrico, fase 3, para evaluar la eficacia y la seguridad de belumosudil en combinación con corticoesteroides frente a placebo en combinación con corticoesteroides en participantes de al menos 12 años con diagnóstico reciente de enfermedad de injerto contra huésped crónica (EICHc).
Estudio aleatorizado, doble ciego, multicéntrico, fase 3, para evaluar la eficacia y la seguridad de belumosudil en combinación con corticoesteroides frente a placebo en combinación con corticoesteroides en participantes de al menos 12 años con diagnóstico reciente de enfermedad de injerto contra huésped crónica (EICHc).
Datos básicos
- Protocolo:
- EFC17757
- EUDRACT:
- 2023-505394-32
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2024
- Año de finalización:
Documentos
- No hay documentos
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
[Translated article] Knowledge of biological therapy in patients with immune-mediated diseases. BIOINFO study.
Segui-Solanes, Carlos; (...); Borras-Blasco, Joaquin
Article. 10.1016/j.farma.2024.08.002. 2024
[Translated article] New challenges in advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2024.05.001. 2024
[Translated article] Pharmacokinetic-guided switching from standard half-life factor VIII to extended half-life pegylated factor VIII in haemophilia A therapy in clinical practice.
Chovi-Trull, Maria; (...); Andres, Jose Luis Poveda
Article. 10.1016/j.farma.2024.12.007. 2025
Alternative donor transplantation for severe aplastic anemia: a comparative study of the SAAWP EBMT.
Montoro J; (...); Peffault de Latour R
Article. 10.1182/blood.2024024173. 2024
Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia With Myelodysplasia-Related Genetic Features: Relevance of the Genetic Underlying Category. A Retrospective Analysis on Behalf of the Acute Leukemia Working Party of the EBMT.
Esteve, Jordi; (...); Ciceri, Fabio
Article. 10.1002/ajh.27647. 2025
Allogeneic stem cell transplantation in de novo core-binding factor acute myeloid leukemia in first complete remission: data from the EBMT.
Al Hamed R; (...); Mohty M
Article. 10.1038/s41409-024-02373-5. 2024
ALLOGENEIC TRANSPLANTATION FOR PATIENTS WITH ACUTE MYELOID LEUKEMIA WITH MYELODYSPLASIA-RELATED FEATURES AS PER THE INTERNATIONAL CONSENSUS CLASSIFICATION (ICC) 2022: FROM THE ALWP OF THE EBMT
Nagler, Arnon; (...); Mohty, Mohamad
Meeting Abstract. 2024
Anti-CD19 CAR-T cell therapy in elderly patients: multicentric real-world experience from GETH-TC/GELTAMO.
Bailen, Rebeca; (...); Kwon, Mi
Article. 10.1016/j.jtct.2024.06.022. 2024
Are any specific respiratory viruses more severe than others in recipients of allogeneic stem cell transplantation? A focus on lower respiratory tract disease.
Pérez A; (...); Piñana JL
Article. 10.1038/s41409-024-02304-4. 2024
Assessment of the Immunodeficiency Scoring Index for predicting outcomes after Respiratory Syncytial Virus infection in Allogeneic Stem Cell Transplant recipients.: ISI performance for RVS infections after allo-HCT.
Mico-Cerda, Mireia; (...); Pinana, Jose Luis
Article. 10.1016/j.jtct.2025.02.012. 2025
Benefits of physical activity self-monitoring in patients with haemophilia: a prospective study with one-year follow-up.
Pérez-Alenda S; (...); Núñez-Cortés R
Article. 10.1111/hae.14988. 2024
Central nervous system manifestations in acute and chronic graft-versus-host disease.
Lambert N; (...); Maquet P
Article. 10.1093/brain/awae340. 2024
CMV REACTIVATIONS IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT FROM HLA-MATCHED AND HAPLOIDENTICAL DONORS WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE.
Article. 10.1016/j.jtct.2024.01.082. 2024
Community-Acquired Respiratory Virus Infections: A Threat to Long-Term survivors after Allogeneic Stem Cell Transplant?
Pinana, Jose Luis; (...); Solano, Carlos
Article. 10.1093/cid/ciae602. 2024
COMPARISON OF THREE STRATEGIES OF GVHD PROPHYLAXIS AFTER T-CELL REPLETE HAPLOIDENTICAL HEMATOPOIETIC TRANSPLANTATION: TACROLIMUS vs. CALCINEURIN INHIBITORS-MMF vs. SIROLIMUS-MMF.
Esquirol A; (...); Martino R
Article. 10.1016/j.jtct.2024.07.027. 2024
CONDITIONING INTENSITY IN STEM CELL TRANSPLANTATION WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE FOR ACUTE MYELOID LEUKEMIA: A STUDY FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT
Sanz, Jaime; (...); Ciceri, Fabio
Meeting Abstract. 2024
Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan.
Watanabe, Mizuki; (...); Gluckman, Eliane
Article. 10.1182/bloodadvances.2023010598. 2024
Cost-effectiveness and cost-utility analysis of haemate-P versus other von willebrand disease treatments in Spain.
Megias-Vericat, Juan E; (...); Yan, Songkai
Article. 10.1080/13696998.2025.2474886. 2025
Chimeric antigen receptor T-cell therapy outcomes in T cell/histiocyte-rich large B-cell lymphoma and subsequent treatment strategies after disease progression: A GELTAMO/GETH study.
Bastos-Oreiro, Mariana; (...); Barba, Pere
Article. 10.1002/hem3.70077. 2025
Development and testing of a mobile app for systematic collection of patient-reported outcomes (PROs) in patients with hemophilia.
Megias-Vericat, J E; (...); Poveda Andres, J L
Letter. 10.1016/j.thromres.2024.109122. 2024
Effect of Consolidation with Allogeneic Hematopoietic Cell Transplant Versus No Consolidation in Patients with Non-Hodgkin Lymphomas Treated with Bispecific Antibodies
Losi, Giulia; (...); Mussetti, Alberto
Meeting Abstract. 10.1182/blood-2024-202933. 2024
Frequency and Impact of Somatic Mutations Alone or in Combination on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Large Study on Behalf of the EBMT Acute Leukemia Working Party
Bazarbachi, Ali; (...); Mohty, Mohamad
Meeting Abstract. 10.1182/blood-2024-204672. 2024
FREQUENCY AND IMPACT OF SOMATIC MUTATIONS ON OUTCOMES OF ACUTE MYELOID LEUKEMIA PATIENTS RECEIVING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: FROM THE EBMT ACUTE LEUKEMIA WORKING PARTY
Bazarbachi, Ali; (...); Mohty, Mohamad
Meeting Abstract. 2024
Gastric Bleeding in Stem Cell Transplantation: A Focus on Gastric Vascular Ectasia Under Post-Transplant Cyclophosphamide, Sirolimus, and Mycophenolate Mofetil Prophylaxis.
Eirís J; (...); Sanz J
Article. 10.1016/j.jtct.2024.10.009. 2024
Haploidentical stem cell donor choice for patients with acute myeloid leukemia: A study from the ALWP of the EBMT.
Sanz, Jaime; (...); Ciceri, Fabio
Article. 10.1182/bloodadvances.2023012133. 2024
Higher survival following transplantation with a mismatched unrelated donor with posttransplant cyclophosphamide-based graft-versus-host disease prophylaxis than with double unit umbilical cord blood in patients with acute myeloid leukemia in first complete remission: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Baron, Frederic; (...); Ciceri, Fabio
Article. 10.1002/ajh.27466. 2024
IDIOPATHIC UPPER GASTROINTESTINAL BLEEDING AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: AN UNPRECEDENTED COMPLICATION
Eiris, Juan; (...); Balaguer-Rosello, Aitana
Meeting Abstract. 2024
Imaging features and clinical data-based network analysis of CAR-T treated B- cell lymphoma patients in relation to their TP53 mutation status
Estepa-Fernandez, A.; (...); Alberich-Bayarri, A.
Meeting Abstract. 2024
Immune reconstitution after single-unit umbilical cord blood transplantation using anti-thymoglobulin and myeloablative conditioning in adults with hematological malignancies.
Article. 10.1007/s00277-024-05758-0. 2024
Incidence, risk factors and therapy response of acute graft-versus-host disease after myeloablative hematopoietic stem cell transplantation with posttransplant cyclophosphamide.
Asensi Cantó P; (...); Sanz J
Article. 10.1038/s41409-024-02391-3. 2024
Incidence, risk factors, and outcomes of BK hemorrhagic cystitis in hematopoietic stem cell transplantation from HLA-matched and haploidentical donors with post-transplant cyclophosphamide.
Chorao, Pedro; (...); Sanz, Jaime
Article. 10.1016/j.jtct.2024.12.006. 2024
Late Adverse Events After Chimeric Antigen Receptor T-Cell Therapy for Patients With Aggressive B-Cell Non-Hodgkin Lymphoma
Camacho-Arteaga, Lina; (...); Agusti, Antonia
Article. 10.1001/jamanetworkopen.2024.61683. 2025
Longitudinal outcome over four decades of allogeneic stem cell transplantation: a single center experience.
Sanz, Miguel Angel; (...); Sanz, Jaime
Article. 10.1038/s41409-024-02319-x. 2024
MATCHED RELATED VERSUS MATCHED UNRELATED VERSUS HAPLOIDENTICAL DONORS IN FLT3-ITD + AML PATIENTS IN CR1: A STUDY FROM THE EBMT ACUTE LEUKEMIA WORKING PARTY
Brissot, Eolia; (...); Ciceri, Fabio
Meeting Abstract. 2024
Mental, emotional and social dimensions of quality of life and their relationship with physical and functional status in adults with haemophilia.
Rodríguez MA; (...); Chimeno-Hernández A
Article. 10.1016/j.thromres.2024.109181. 2024
Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases
Artacho, Alejandro; (...); Ubeda, Carles
Article. 10.1186/s40168-024-01948-0. 2024
New challenges of advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2023.11.008. 2024
Ofatumumab as part of reduced intensity conditioning in high risk B-cell lymphoma patients: final long-term analysis from a prospective multicenter Phase-II Trial
Cabrero M; (...); Caballero D
Article. 10.1038/s41409-023-02171-5. 2024
OLD MATCHED SIBLING DONOR VERSUS YOUNG HAPLOIDENTICAL DONOR FOR ELDERLY PATIENTS WITH ACUTE MYELOID LEUKEMIA TRANSPLANTED IN FIRST REMISSION
Poire, Xavier; (...); Ciceri, Fabio
Meeting Abstract. 2024
Older MRD vs. younger MUD in patients older than 50 years with AML in remission using post-transplant cyclophosphamide.
Piemontese S; (...); Ciceri F
Article. 10.1038/s41375-024-02359-8. 2024
Omicron SARS-CoV-2 infection management and outcomes in patients with hematologic disease and recipients of cell therapy.
Pinana, Jose Luis; (...); Solano, Carlos
Article. 10.3389/fonc.2024.1389345. 2024
Outcome of Human Parainfluenza Virus infection in allogeneic stem cell transplantation recipients: possible impact of ribavirin therapy.
Perez, Ariadna; (...); Pinana, Jose Luis
Article. 10.1007/s15010-024-02213-0. 2024
OUTCOMES OF ALLOGENEIC HAEMATOPOIETIC STEM-CELL TRANSPLANTATION IN MYELOFIBROSIS: A MULTICENTER STUDY
Fernandez-Barge, Tatiana; (...); Bermudez Rodriguez, Maria Aranzazu
Meeting Abstract. 2024
Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review.
Ballesta-Lopez, Octavio; (...); Poveda-Andres, Jose Luis
Article. 10.3390/ijms26041760. 2025
POOLED FECAL ALLOGENEIC MICROBIOTHERAPY FOR REFRACTORY GASTROINTESTINAL ACUTE GRAFT-VERSUSHOST DISEASE: RESULTS FROM THE EARLY ACCESS PROGRAM IN EUROPE
Malard, Florent; (...); Mohty, Mohamad
Meeting Abstract. 2024
Pooled Fecal Allogeneic Microbiotherapy for Refractory Gastrointestinal Acute Graft-Versus-Host Disease: Results from the Early Access Program in Europe
Malard, Florent; (...); Mohty, Mohamad
Meeting Abstract. https://doi.org/10.1182/blood-2024-201251. 2024
Post-Transplant Cyclophosphamide Versus Antithymocyte Globulin in Haploidentical Transplantation for Relapsed/Refractory Acute Myeloid Leukemia: A Study from the Acute Leukemia Working Party of the EBMT
Battipaglia, Giorgia; (...); Ciceri, Fabio
Meeting Abstract. 10.1182/blood-2024-207391. 2024
Posttransplant cyclophosphamide versus anti-thymocyte globulin versus combination for graft-versus-host disease prevention in haploidentical transplantation for adult acute myeloid leukemia: A report from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party.
Bazarbachi, Abdul-Hamid; (...); Mohty, Mohamad
Article. 10.1002/cncr.35365. 2024
Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis in HLA-Matched and Haploidentical Donor Transplantation for Patients with Hodgkin Lymphoma: A Comparative Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation.
Montoro, Juan; (...); Glass, Bertram
Article. 10.1016/j.jtct.2023.11.021. 2024
Predicting survival, neurotoxicity and response in B-cell lymphoma patients treated with CAR-T therapy using an imaging features-based model
Ferrer-Lores, Blanca; (...); Alberich-Bayarri, Angel
Article. 10.1186/s13550-024-01172-9. 2024
PTCy vs CNI-based GVHD prophylaxis in HLA-matched transplants for Hodgkin lymphoma: a study of the LWP of the EBMT.
Montoro J; (...); Glass B
Article. 10.1182/bloodadvances.2024013328. 2024
REAL LIFE MANAGEMENT OF ANTIBIOTIC THERAPY IN HSCT RECIPIENTS - FOCUS ON DE-ESCALATION IN PRE-ENGRAFTMENT NEUTROPENIA, THE STUDY FROM THE EBMT INFECTIOUS DISEASES WORKING PARTY (IDWP)
Mikulska, Malgorzata; (...); de la Camara, Rafael
Meeting Abstract. 2024
Ruxolitinib for foreign body reaction to silicone in a patient with chronic graft-versus-host disease.
Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael
Letter. 10.1111/ijd.17365. 2024
RUXOLITINIB IN ACUTE AND CHRONIC GRAFT-VERSUS RECEPTOR DISEASE: LONG-TERM REAL-LIFE EXPERIENCE IN A MULTI-CENTRE STUDY IN PEDIATRIC POPULATION
Escamilla Gomez, Virginia; (...); Garcia Gutierrez, Valentin
Meeting Abstract. 2024
RUXOLITINIB IN ACUTE AND CHRONIC GRAFT-VERSUS-RECEPTOR DISEASE: LONG-TERM REAL-LIFE EXPERIENCE IN A MULTI-CENTRE STUDY
Escamilla Gomez, Virginia; (...); Perez-Simon, Jose Antonio
Meeting Abstract. 2024
Total body irradiation versus thiotepa/busulfan-based conditioning regimens for myeloablative allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia.
Article. 10.1038/s41409-024-02298-z. 2024
Toxic-metabolic encephalopathy induced by metronidazole and disulfiram: classics never die.
Chovi-Trull, Maria; (...); Poveda-Andres, Jose Luis
Article. 10.1136/ejhpharm-2024-004184. 2024
TRENDS IN THE USE OF HEMATOPOIETIC CELL TRANSPLANTATION FOR ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A REPORT FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT
Giebel, Sebastian; (...); Ciceri, Fabio
Meeting Abstract. 10.1007/s00277-019-03771-2. 2024
Umbilical Cord Blood Transplantation for Fanconi Anemia With a Special Focus on Late Complications: a Study on Behalf of Eurocord and SAAWP-EBMT.
Rafii H; (...); Gluckman E
Article. 10.1016/j.jtct.2024.02.024. 2024
UNRELATED DONOR SELECTION FOR STEM CELL TRANSPLANT USING POST-TRANSPLANT CYCLOPHOSPHAMIDE FOR ACUTE MYELOID LEUKEMIA: A STUDY FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT
Sanz, Jaime; (...); Ciceri, Fabio
Meeting Abstract. 2024
Younger unrelated donors may be preferable over HLA match in the PTCy era: A study from the ALWP of the EBMT.
Sanz, Jaime; (...); Ciceri, Fabio
Article. 10.1182/blood.2023023697. 2024