Portal de investigación
Estudio de fase IIb aleatorizado, doble ciego, controlado con placebo, multicéntrico, de búsqueda de dosis de AZD3427 en participantes con insuficiencia cardíaca e hipertensión pulmonar por cardiopatía izquierda (grupo 2 de la OMS).
Datos básicos
- Código:
- D8330C00003
- Protocolo:
- D8330C00003
- EUDRACT:
- 2022-502382-25-00
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Dotación:
- Año de incio:
- 2023
- Año de finalización:
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
[[en]]Peripheral access ultrafiltration in adults with complex congenital heart disease and refractory congestion.
Guerrero Cervera B; (...); Almenar Bonet L
Article. 10.1016/j.rec.2024.08.015. 2024
Analysis of complications in patients with ECMO as a bridge to transplantation since the beginning of the technique (2007-2023)
Guerrero Cervera, Borja; (...); Almenar Bonet, Luis
Meeting Abstract. 2024
Analysis of the implantation of heart failure with reduced ejection fraction treatment in clinical practice and its impact on achieving target doses
Esteban Fernandez, A. Alberto; (...); Fernandez, V. Alonso
Meeting Abstract. 2023
Annual evolution of the prescription of drugs with prognostic implications in acute decompensated heart failure with reduced ejection fraction.
López-Vilella R; (...); Almenar Bonet L
Article. 10.1186/s12872-024-03728-y. 2024
Circulating long non-coding RNAs detection after heart transplantation and its accuracy in the diagnosis of acute cardiac rejection.
Pérez-Carrillo L; (...); Roselló-Lletí E
Letter. 10.1186/s40364-024-00590-0. 2024
Clinical phenotypes according to diuretic combination in acute heart failure.
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Article. 10.1016/j.hjc.2023.03.009. 2023
Clinical profile of an unselected population with heart failure treated with vericiguat in real life: differences with the VICTORIA trial
Esteban-Fernandez, Alberto; (...); VERISEC Registry Researchers
Article. 10.3389/fcvm.2024.1504427. 2025
Clinical profile of heart failure patients starting vericiguat in clinical practice
Esteban Fernandez, A. Alberto; (...); Diez Villanueva, P.
Meeting Abstract. 2024
Clinical profiling of patients admitted with acute heart failure: a comprehensive survival analysis.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.3389/fcvm.2024.1381514. 2024
Clinical utility and safety of finerenone in patients with heart failure: Rationale and design of FINE registry.
Alonso Salinas, Gonzalo Luis; (...); Diez-Villanueva, Pablo
Article. 10.1002/ehf2.15260. 2025
Clinical, echocardiographic and analytical patterns of biomarkers in cardiac amyloidosis; a real-world analysis.
Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.
Meeting Abstract. 2024
Combining Serum miR-144-3p and miR-652-3p as Potential Biomarkers for the Early Diagnosis and Stratification of Acute Cellular Rejection in Heart Transplantation Patients.
Pérez-Carrillo L; (...); Roselló-Lletí E
Article. 10.1097/TP.0000000000004622. 2023
Comparative Temporal Analysis of Morbidity and Early Mortality in Heart Transplantation with Extracorporeal Membrane Oxygenation Support: Exploring Trends over Time
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Article. 10.3390/biomedicines12092109. 2024
Comprehensive survival analysis in acute heart failure: profiling patients through clinical examination at admission
Raquel Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2024
Correlates of musculoskeletal pain and kinesiophobia in older adults with heart failure: A structural equation model.
Sentandreu-Mano, Trinidad; (...); Marques-Sule, Elena
Article. 10.1016/j.gerinurse.2023.07.003. 2023
Destination Therapy Strategies of Advanced Heart Failure in Elderly Non-Heart Transplant Candidates: A Propensity Matching Analysis from the LEVO-D and REGALAD Registries
Dobarro, David; (...); Gonzalez-Costello, Jose
Article. 10.3390/life14121570. 2024
Donor-derived cell-free DNA as a new biomarker for cardiac allograft rejection: A prospective study (FreeDNA-CAR).
Jimenez-Blanco, Marta; (...); Segovia-Cubero, Javier
Article. 10.1016/j.healun.2024.11.009. 2024
Donor-Derived Cell-Free DNA as a Potential Biomarker for Acute Cellular Rejection Surveillance (FreeDNA-CAR Study)
Bravo, M. Jimenez -Blanco; (...); Segovia-Cubero, J.
Meeting Abstract. 2023
Donor-Derived Cell-Free DNA Correlates Well with NT-ProBNP in Heart Transplant Recipients Undergoing Routine Endomyocardial Biopsies During First Year Post-Heart Transplant
Bravo, M. Jimenez-Blanco; (...); Segovia-Cubero, J.
Meeting Abstract. 2023
Effects of COVID-19 Lockdown on Heart Failure Patients: A Quasi-Experimental Study.
Sánchez-González JL; (...); Marques-Sule E
Article. 10.3390/jcm12227090. 2023
Facilitators and barriers to perform physical activity in patients post-heart transplantation: a qualitative study.
Klompstra L; (...); Marques-Sule E
Article. 10.1093/eurjcn/zvae144. 2024
Impact of left ventricular unloading on postheart transplantation outcomes in patients bridged with VA-ECMO.
Enríquez-Vázquez D; (...); Crespo-Leiro MG
Article. 10.1016/j.rec.2024.09.005. 2024
Impact of preoperative left ventricular unloading on post-transplant outcomes of candidates bridged with venoarterial extracorporeal membrane oxygenation
Enriquez Vazquez, D.; (...); Crespo-Leiro, M.
Meeting Abstract. 2024
Impact on Survival of Heart and Heart-Lung Transplantation in Patients With Cyanotic and Noncyanotic Congenital Heart Diseases.
Donoso-Trenado, Victor; (...); Almenar-bonet, Luis
Article. 10.1016/j.transproceed.2024.12.005. 2024
Implications of Molecular Markers in Brain-Dead Donors in Primary Graft Dysfunction and Rejection After Heart Transplantation: The Potential Role of Preconditioning
Herrador-Galindo, L.; (...); Moreno-Gonzalez, G.
Meeting Abstract. 10.1016/j.healun.2024.02.526. 2024
Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial.
Santas E; (...); Núñez J
Article. 10.1002/ehf2.14630. 2023
Incidence and Prognosis of Colorectal Cancer After Heart Transplantation: Data From the Spanish Post-Heart Transplant Tumor Registry
Sagastagoitia-Fornie, Marta; (...); Crespo-Leiro, Maria G.
Article. 10.3389/ti.2023.11042. 2023
Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction.
Esteban-Fernández A; (...); Ridocci-Soriano F
Article. 10.1007/s00392-023-02241-0. 2024
Is the Benefit of Treating Iron Deficiency Greater in Acute Heart Failure with Renal Dysfunction?
Lopez-Vilella, Raquel; (...); Almenar Bonet L
Article. 10.3390/life13040915. 2023
Is the benefit of treating iron deficiency greater in acute heart failure with renal dysfunction?
Lopez Vilella, R. Raquel; (...); Bonet, L. Almenar
Meeting Abstract. 2023
Kinesiophobia and associated variables in patients with heart failure.
Sentandreu-Mano, Trinidad; (...); Marques-Sule, Elena
Article. 10.1093/eurjcn/zvad072. 2023
Kinesiophobia in heart transplantation patients: a cross-sectional study with a special focus in sex differences
Moreno Segura, N.; (...); Marques-Sule, E.
Meeting Abstract. 2023
Mechanical circulatory support in severe primary graft dysfunction: Peripheral cannulation but not earlier implantation improves survival in heart transplantation.
Olivella, Aleix; (...); Gonzalez-Costello, Jose
Article. 10.1016/j.healun.2023.03.008. 2023
Mortality after the first hospital admission for acute heart failure de novo vs. acutely decompensated heart failure with reduced ejection fraction
Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Mortality After the First Hospital Admission for Acute Heart Failure, De Novo Versus Acutely Decompensated Heart Failure With Reduced Ejection Fraction.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.amjcard.2023.03.008. 2023
Musculoskeletal disorders in men and women with heart transplantation. A cross-sectional study
Segura, N. Moreno; (...); Marques-Sule, E.
Meeting Abstract. 2023
No Obesity Paradox for Health-Related Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Insights from the VIDA Multicenter Study
Cassado-Valls, Paula; (...); Comin-Colet, Josep
Article. 10.3390/jcm13247558. 2024
Particularities of foundational therapy in patients with newly diagnosed heart failure and reduced LVEF secondary to tachycardiomyopathy
Esteban Fernandez, A. Alberto; (...); De Juan Baguda, J.
Meeting Abstract. 2024
Percutaneous biventricular mechanical assistance as a bridge to heart transplant.
Perez-Guillen, Manuel; (...); Martinez-Leon, Juan B
Case Reports. 10.1016/j.rec.2023.07.007. 2023
Practical Requirements for the Development of an Advanced Cardiorenal Unit
Almenar-Bonet, Luis; (...); Sanchez-Perez, Pilar
Review. 10.1159/000536104. 2024
Predicting Sarcopenia and Frailty Risk in Patients Post Heart Transplantation.
Sentandreu-Mano, Trinidad; (...); Machado, Felipe V C
Article. 10.1111/ctr.70027. 2025
Prevalence, characteristics, and phenotype associated with tachycardiomyopathy in a cohort of patients first hospitalized for heart failure with reduced ejection fraction
Otero Garcia, O.; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 2024
Prevalence, Characteristics, and Prognostic Relevance of Donor-Transmitted Coronary Artery Disease in Heart Transplant Recipients.
Couto-Mallón D; (...); Crespo-Leiro MG
Article. 10.1016/j.jacc.2023.06.016. 2023
Prognosis after heart transplant in patients with hypertrophic and restrictive cardiomyopathy. A nationwide registry analysis.
Urbistondo, Francisco Gonzalez; (...); De Prada, Jose Antonio Vazquez
Article. 10.1016/j.rec.2023.10.006. 2023
Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. COMFE registry
Vega, D. Garcia; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.1187. 2024
Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. implications for their clinical management. COMFE registry
Garcia Vega, D. David; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.1187. 2024
Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.
Ufnal, Marcin; (...); Rosenkranz, Stephan
Article. 10.1002/ehf2.15203. 2025
Repetitive ambulatory levosimendan as a bridge to heart transplantation.
Baguda, Javier De Juan; (...); Gonzalez-Costello, Jose
Article. 10.1016/j.rec.2023.07.002. 2023
Revascularization of Donor Transmitted Coronary Artery Disease After Heart Transplantation: Impact on Survival and Cardiovascular Events. Insights from the DONOR-CAD Study
Couto-Mallon, D.; (...); Crespo-Leiro, M. G.
Meeting Abstract. 2023
Review of the allocation criteria for heart transplant in Spain in 2023 . SEC-Heart Failure Association/ONT/SECCE consensus document
González-Costello J; (...); Domínguez-Gil B
Review. 10.1016/j.rec.2023.11.001. 2024
Role of vericiguat in management of patients with heart failure with reduced ejection fraction after worsening episode.
Olivella, Aleix; (...); Facila Rubio, Lorenzo
Article. 10.1002/ehf2.14647. 2023
Severity of Donor Transmitted Coronary Artery Disease and Survival after Heart Transplantation. Results from the Donor Coronary Artery Disease (DONOR-CAD) Study
Couto-Mallon, D.; (...); Crespo-Leiro, M. G.
Meeting Abstract. 2023
Sex, Temporary Mechanical Circulatory Support, and HeartTransplantation: Insights From a Multi-Institutional SpanishRegistry.
Enriquez-Vazquez, Daniel; (...); Crespo-Leiro, Maria G.
Letter. 10.1016/j.jchf.2023.07.027. 2023
Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction
Otero Garcia, O. Oscar; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.836. 2024
Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction
Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.836. 2024
Spanish heart transplant registry. 34th official report of the Heart Failure Association of the Spanish Society of Cardiology.
González-Vílchez F; (...); García-Romero E
Article. 10.1016/j.rec.2023.06.013. 2023
Spanish heart transplant registry. 35th official report of the Heart Failure Association of the Spanish Society of Cardiology.
González-Vílchez F; (...); García-Romero E
Article. 10.1016/j.rec.2024.05.015. 2024
Technology Usage, Physical Activity, and Motivation in Patients With Heart Failure and Heart Transplantation.
Deka P; (...); Marques-Sule E
Article. 10.1097/CIN.0000000000001049. 2023
Therapeutic approach in heart failure with poor diuretic response. Peripheral ultrafiltration vs. conventional treatment
Lopez-Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Therapeutic approach in heart failure with poor diuretic response: peripheral ultrafiltration vs. conventional treatment.
López-Vilella R; (...); Almenar Bonet L
Article. 10.1002/ehf2.14386. 2023
Unveiling the prognostic journey: renal function trajectories in 'de novo' heart failure with reduced ejection fraction - insights from a cohort study and their impact on patient outcomes
Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.835. 2024
Use of a surgically implanted, extracorporeal continuous flow circulatory support system as a bridge to heart transplantation
Cabezon Villalba, G. Gonzalo; (...); Crespo-Leiro, M. G. C. L.
Meeting Abstract. 2023
Use of a surgically implanted, nondischargeable, extracorporeal continuous flow circulatory support system as a bridge to heart transplant.
Villalba, Gonzalo Cabezon; (...); Crespo-Leiro, Maria G
Article. 10.1016/j.rec.2023.05.002. 2024
Usefulness of biomarkers to predict prognosis after heart transplant
Lopez-Vilella, Raquel; (...); Boneta, Luis Almenar
Article. 10.1016/j.rec.2024.04.019. 2024
Usefulness of short-term peripheral ambulatory ultrafiltration in heart failure refractory to diuretics. Initial experience.
Guerrero Cervera B; (...); Almenar Bonet L
Article. 10.1016/j.medcli.2023.04.008. 2023
Vaccine-carditis study: Spanish multicenter registry of inflammatory heart disease after COVID-19 vaccination.
Pastor Pueyo, Pablo; (...); Worner Diz, Fernando
Article. 10.1007/s00392-023-02225-0. 2023
Validation of miR-181A-5p as a biomarker of acute rejection after heart transplantation. Multicenter study
Crespo-Leiro, M.; (...); Domenech-Garcia, N.
Meeting Abstract. 2023
What clinical parameters are associated with the prescription at hospital discharge of all medications with prognostic improvement? Analysis in de novo heart failure with reduced ejection fraction
Lopez Vilella, R. Raquel; (...); Bonet, Almenar
Meeting Abstract. 2024
What factors are associated with myocardial recovery following admission for acute heart failure? Study in patients with de novo diagnosis and reduced left ventricular ejection fraction
Donoso Trenado, V.; (...); Almenar-Bonet, L.
Meeting Abstract. 2024
What motivates heart transplantation patients to exercise and engage in physical activity? A network analysis.
Marques-Sule, Elena; (...); Machado, Felipe V C
Article. 10.1093/eurjcn/zvad051. 2023