Portal de investigación
Estudio prospectivo, multicéntrico y abierto para evaluar la eficacia del esmolol en la identificación precoz de las alteraciones cardiovasculares inducidas por la cirrosis, la diabetes mellitus y los tratamientos cardiotóxicos.
Datos básicos
- Protocolo:
- CIBER-bB-ECHO
- EUDRACT:
- 2021-003889-12
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2023
- Año de finalización:
Objetivos del proyecto
Objetivo Principal: Evaluar la eficacia del esmolol en la identificación precoz de las alteraciones cardiovasculares inducidas por la cirrosis, la diabetes mellitus y los tratamientos cardiotóxicos. Objetivos Secundarios: 1. Determinar la reducción de la variabilidad en la medida de la función sistólica del VI que se obtiene mediante la combinación del bloqueo adrenérgico agudo. Esta reducción de la variabilidad se estudiará referente a dos índices convencionales (FE y strain longitudinal global) y a un índice alternativo (EIVPD). 2. Establecer los patrones de normalidad y cambios fisiológicos en la medida de la función miocárdica durante un periodo longitudinal en pacientes y normales, obtenidos en situación basal y tras la administración de esmolol. 3. Comparar la exactitud diagnóstica (análisis de curvas ROC) de la ecocardiografía con esmolol con la ecocardiografía basal para identificar pacientes con daño miocárdico asociado a DM2 (con y sin ICFEN) y cirrosis avanzada. 4. Comparar la capacidad de anticipación de la ecocardiografía con esmolol con la ecocardiografía basal para la predicción de cardiotoxicidad inducida por antineoplásicos.
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
Annual evolution of the prescription of drugs with prognostic implications in acute decompensated heart failure with reduced ejection fraction.
López-Vilella R; (...); Almenar Bonet L
Article. 10.1186/s12872-024-03728-y. 2024
CA125: a new biomarker in patients with Fontan circulation (vol 76, pg 112, 2023)
Fuentes, Francisco Buendia; (...); Soriano, Joaquin Rueda
Correction. 10.1016/j.rec.2023.03.018. 2023
Circulating long non-coding RNAs detection after heart transplantation and its accuracy in the diagnosis of acute cardiac rejection.
Pérez-Carrillo L; (...); Roselló-Lletí E
Letter. 10.1186/s40364-024-00590-0. 2024
Clinical phenotypes according to diuretic combination in acute heart failure.
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Article. 10.1016/j.hjc.2023.03.009. 2023
Combining Serum miR-144-3p and miR-652-3p as Potential Biomarkers for the Early Diagnosis and Stratification of Acute Cellular Rejection in Heart Transplantation Patients.
Pérez-Carrillo L; (...); Roselló-Lletí E
Article. 10.1097/TP.0000000000004622. 2023
Diagnosis and treatment of patients with ANOCA. Consensus document of the SEC-Clinical Cardiology Association/SEC-Interventional Cardiology Association/SEC-Ischemic Heart Disease and Acute Cardiac Care Association/SEC-Cardiovascular Imaging Association
Escobar, Carlos; (...); Tejedor, Ana Viana
Article. https://doi.org/10.24875/RECICE.M23000420. 2024
Incidence and Risk Factors for Development of Cardiac Toxicity in Adult Patients with Newly Diagnosed Acute Myeloid Leukemia
Boluda, Blanca; (...); Montesinos, Pau
Article. 10.3390/cancers15082267. 2023
Is the Benefit of Treating Iron Deficiency Greater in Acute Heart Failure with Renal Dysfunction?
Lopez-Vilella, Raquel; (...); Almenar Bonet L
Article. 10.3390/life13040915. 2023
Is the benefit of treating iron deficiency greater in acute heart failure with renal dysfunction?
Lopez Vilella, R. Raquel; (...); Bonet, L. Almenar
Meeting Abstract. 2023
Left atrial strain in adults after the arterial switch operation for transposition of the great arteries.
Buendia-Fuentes, Francisco; (...); Rueda, Joaquin
Article. 10.1111/echo.15750. 2024
Mortality after the first hospital admission for acute heart failure de novo vs. acutely decompensated heart failure with reduced ejection fraction
Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Mortality After the First Hospital Admission for Acute Heart Failure, De Novo Versus Acutely Decompensated Heart Failure With Reduced Ejection Fraction.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.amjcard.2023.03.008. 2023
Peripheral access ultrafiltration as a treatment for cardiorenal syndrome with inadequate diuretic response. Initial experience
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Letter. 10.1016/j.recesp.2022.04.017. 2023
Practical Requirements for the Development of an Advanced Cardiorenal Unit
Almenar-Bonet, Luis; (...); Sanchez-Perez, Pilar
Review. 10.1159/000536104. 2024
Prevalence, characteristics, and phenotype associated with tachycardiomyopathy in a cohort of patients first hospitalized for heart failure with reduced ejection fraction
Otero Garcia, O.; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 2024
Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. COMFE registry
Vega, D. Garcia; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.1187. 2024
Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. implications for their clinical management. COMFE registry
Garcia Vega, D. David; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.1187. 2024
Role of transseptal approach during TAVI in a patient with uncrossable severe bicuspid aortic stenosis
Martinez-Sole, Julia; (...); Diez-Gil, Jose Luis
Editorial Material. 10.24875/RECICE.M22000310. 2023
Role of transseptal approach during TAVI in a patient with uncrossable severe bicuspid aortic stenosis. Case resolution
Martinez-Sole, Julia; (...); Diez-Gil, Jose Luis
Editorial Material. 10.24875/RECICE.M22000312. 2023
Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction
Otero Garcia, O. Oscar; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.836. 2024
Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction
Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.836. 2024
Therapeutic approach in heart failure with poor diuretic response. Peripheral ultrafiltration vs. conventional treatment
Lopez-Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Therapeutic approach in heart failure with poor diuretic response: peripheral ultrafiltration vs. conventional treatment.
López-Vilella R; (...); Almenar Bonet L
Article. 10.1002/ehf2.14386. 2023
Unveiling the prognostic journey: renal function trajectories in 'de novo' heart failure with reduced ejection fraction - insights from a cohort study and their impact on patient outcomes
Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.835. 2024
Usefulness of biomarkers to predict prognosis after heart transplant
Lopez-Vilella, Raquel; (...); Boneta, Luis Almenar
Article. 10.1016/j.rec.2024.04.019. 2024
Usefulness of short-term peripheral ambulatory ultrafiltration in heart failure refractory to diuretics. Initial experience.
Guerrero Cervera B; (...); Almenar Bonet L
Article. 10.1016/j.medcli.2023.04.008. 2023
What clinical parameters are associated with the prescription at hospital discharge of all medications with prognostic improvement? Analysis in de novo heart failure with reduced ejection fraction
Lopez Vilella, R. Raquel; (...); Bonet, Almenar
Meeting Abstract. 2024
What factors are associated with myocardial recovery following admission for acute heart failure? Study in patients with de novo diagnosis and reduced left ventricular ejection fraction
Donoso Trenado, V.; (...); Almenar-Bonet, L.
Meeting Abstract. 2024