Portal de recerca
Retirada de tratamiento farmacologico en pacientes respondedores a terapia de resincronización cardiaca: Estudio abierto y aleatorizado.
Dades bàsiques
- Protocol:
- IMIB-RMV-2021-02
- EURDRACT:
- 2021-001327-41
- NCT:
- Centre:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Any inici:
- 2022
- Any de finalització:
- 2025
Objectius del projecte
Objetivo Principal: Determinar el efecto de la retirada del TF en pacientes portadores de TRC con FEVI recuperada, en términos tanto de parámetros de imagen, evaluada mediante cambios en la FEVI y volumen telesistólico indexado del VI (VTSVIi) como de parámetros clínicos que traduzcan empeoramiento de la IC. Objetivos Secundarios: 1. Determinar la seguridad de la retirada del TF en pacientes portadores de TRC con FEVI recuperada, en términos de eventos adversos en el seguimiento (muerte total, muete muerte cardiovascular, ingreso hospitalario o consulta en Urgencias por IC y arritmias supraventriculares o ventriculares sostenidas) 2. La determinación de cambios en otras medidas ecocardiogáficas así como en los niveles de péptidos natriuréticos, constantes vitales y puntuaciones en los test de calidad de vida. 3. La influencia de genotipo de la miocardiopatía en la respuesta a la retirada de la medicación.
Documents
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Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
Ability of antigen carbohydrate 125 for diagnosis of heart failure with preserved ejection fraction
De Juan Baguda, J. Javier; (...); Delgado Jimenez, J. F.
Meeting Abstract. 2024
Acute performance of stylet driven leads for left bundle branch area pacing: A comparison with lumenless leads
Cano, Oscar; (...); Batul, Syeda Atiqa
Article. 10.1016/j.hroo.2023.11.014. 2023
Alpha-cardiac Actin Serum Expression Levels Detect Acute Cellular Rejection in Heart Transplant Patients.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.1097/TP.0000000000004273. 2022
Alteration in Golgi apparatus fragmentation related genes in human dilated cardiomyopathy.
Gonzalez-Torrent, Irene; (...); Rosello-Lleti, Esther
Article. 10.1038/s41598-025-92758-3. 2025
Alterations in Mitochondrial Oxidative Phosphorylation System: Relationship of Complex V and Cardiac Dysfunction in Human Heart Failure
Gimenez-Escamilla, Isaac; (...); Rosello-Lleti, Esther
Article. 10.3390/antiox13030285. 2024
Alterations of mitochondrial bioenergetics in human hearts with ischemic and dilated cardiomyopathy
Tarazon, E.; (...); Rosello-Lleti, E.
Meeting Abstract. 2023
Altered MicroRNA Maturation in Ischemic Hearts: Implication of Hypoxia on XPO5 and DICER1 Dysregulation and RedoximiR State.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.3390/antiox12071337. 2023
Analysis of complications in patients with ECMO as a bridge to transplantation since the beginning of the technique (2007-2023)
Guerrero Cervera, Borja; (...); Almenar Bonet, Luis
Meeting Abstract. 2024
Analysis of Heart Transplant Survival According to Difference in Age Between Donor and Recipient.
Lopez-Vilella, Raquel; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.014. 2022
Analysis of heart transplantation survival according to difference in age between donor and recipient
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Analysis of the snoRNA profile in ischemic and dilated cardiomyopathy
Tarazon, E.; (...); Rosello-Lleti, E.
Meeting Abstract. 2023
Annual evolution of the prescription of drugs with prognostic implications in acute decompensated heart failure with reduced ejection fraction.
López-Vilella R; (...); Almenar Bonet L
Article. 10.1186/s12872-024-03728-y. 2024
CA125: a new biomarker in patients with Fontan circulation (vol 76, pg 112, 2023)
Fuentes, Francisco Buendia; (...); Soriano, Joaquin Rueda
Correction. 10.1016/j.rec.2023.03.018. 2023
CA125: a new biomarker in patients with Fontan circulation.
Fuentes, Francisco Buendia; (...); Soriano, Joaquin Rueda
Article. 10.1016/j.rec.2022.05.029. 2022
Cardiac Allograft Rejection Induces Changes in Nucleocytoplasmic Transport: RANGAP1 as a Potential Non-Invasive Biomarker.
Lozano-Edo, Silvia; (...); Martinez-Dolz, Luis
Article. 10.3390/jpm12060913. 2022
Cardiac rejection diagnosis using serum mRNA encoding proteins related to fibrotic process
Rosello-Lleti, E.; (...); Tarazon, E.
Meeting Abstract. 2023
Cardiac sodium/hydrogen exchanger (NHE11) as a novel potential target for SGLT2i in heart failure
Perez-Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Circulating long non-coding RNAs detection after heart transplantation and its accuracy in the diagnosis of acute cardiac rejection.
Pérez-Carrillo L; (...); Roselló-Lletí E
Letter. 10.1186/s40364-024-00590-0. 2024
Clinical phenotypes according to diuretic combination in acute heart failure.
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Article. 10.1016/j.hjc.2023.03.009. 2023
Clinical profiling of patients admitted with acute heart failure: a comprehensive survival analysis.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.3389/fcvm.2024.1381514. 2024
Clinical, echocardiographic and analytical patterns of biomarkers in cardiac amyloidosis; a real-world analysis.
Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.
Meeting Abstract. 2024
Combining Serum miR-144-3p and miR-652-3p as Potential Biomarkers for the Early Diagnosis and Stratification of Acute Cellular Rejection in Heart Transplantation Patients.
Pérez-Carrillo L; (...); Roselló-Lletí E
Article. 10.1097/TP.0000000000004622. 2023
Combining serum miR-144-3p and miR-652-3p as potential biomarkers for the early diagnosis and stratification of acute cellular rejection in heart transplantation patients
Perez-Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Comparative Temporal Analysis of Morbidity and Early Mortality in Heart Transplantation with Extracorporeal Membrane Oxygenation Support: Exploring Trends over Time
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Article. 10.3390/biomedicines12092109. 2024
Comprehensive survival analysis in acute heart failure: profiling patients through clinical examination at admission
Raquel Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2024
Conduction System Pacing for Cardiac Resynchronization Therapy
Cano, Oscar; (...); Martinez-Dolz, Luis
Review. 10.3390/jcdd10110448. 2023
COVID-19 infection in heart transplants in pre- and post-vaccination periods
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
COVID-19 Infection in Heart Transplants in Pre- and Postvaccination Periods.
Donoso Trenado, Victor; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.005. 2022
Culprit-Lesion Drug-Coated-Balloon Percutaneous Coronary Intervention in Patients Presenting with ST-Elevation Myocardial Infarction (STEMI)
Sanz-Sanchez, Jorge; (...); Santos, Ignacio Amat
Article. 10.3390/jcm14030869. 2025
Changes in the Treatment of Decompensated Advanced Heart Failure During Hospitalization and at Discharge.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.002. 2022
Changes over the years in the indication for heart-lung transplantation in Spain
Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Disturbance of iron metabolism related genes in advanced heart failure
Tarazon, E.; (...); Rosello-Lleti, E.
Meeting Abstract. 2023
Does fractional flow reserve impact on clinical outcomes by reducing number of stents and contrast media? Findings from a systematic review (N = 56,185) and meta-analysis.
Teira Calderón A; (...); Garcia-Garcia HM
Letter. 10.1016/j.carrev.2023.12.010. 2024
Does Fractional Flow Reserve Impact on Clinical Outcomes? Findings From a Systematic Review (n=56,185) and Meta-Analysis
Teira Calderon, A.; (...); Garcia-Garcia, H. M.
Meeting Abstract. 2024
Dynamics and prognostic role of persistent angina in chronic coronary syndrome with clinical, angiographic and stress CMR evidence of ischemia
Merenciano-Gonzalez, H.; (...); Bodi, V
Meeting Abstract. 10.1093/eurheartj/ehae666.1329. 2024
Dystrophinopathy Phenotypes and Modifying Factors in DMD Exon 45-55 Deletion
Poyatos-Garcia, Javier; (...); Jesus Vilchez, Juan
Article. 10.1002/ana.26461. 2022
Emerging role of circulating piRNAs in the diagnosis of heart transplant rejection.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.1016/j.healun.2024.11.039. 2024
Endothelial Biomarkers Are Superior to Classic Inflammatory Biomarkers in Community-Acquired Pneumonia.
González-Jiménez P; (...); Méndez R
Article. 10.3390/biomedicines12102413. 2024
Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice?
Tortosa-Carreres J; (...); Pérez-Miralles FC
Article. 10.1016/j.jneuroim.2024.578428. 2024
Evolutionary description of heart transplantation and heart-lung transplantation in congenital heart disease
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Evolutionary Description of Heart Transplantation and Heart-Lung Transplantation in Congenital Heart Disease.
Donoso Trenado, Victor; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.006. 2022
Evolving Indications for Heart-Lung Transplant in Spain.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.003. 2022
Golgi Apparatus fragmentation in dilated cardiomyopathy and its relationship with the alteration of vesicular transport
Gimenez-Escamilla, I.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Impact of Advanced Age on the Incidence of Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stable Coronary Artery Disease in a Real-World Setting in Spain.
González-Juanatey C; (...); Savana Research Group
Article. 10.3390/jcm12165218. 2023
Impact on Survival of Heart and Heart-Lung Transplantation in Patients With Cyanotic and Noncyanotic Congenital Heart Diseases.
Donoso-Trenado, Victor; (...); Almenar-bonet, Luis
Article. 10.1016/j.transproceed.2024.12.005. 2024
Initial and Residual Cardiovascular Damage Remaining at Day 30 in Community-acquired Pneumonia
Ocana, R. Mendez; (...); Menendez, R.
Meeting Abstract. https://doi.org/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A6241. 2024
Is the Benefit of Treating Iron Deficiency Greater in Acute Heart Failure with Renal Dysfunction?
Lopez-Vilella, Raquel; (...); Almenar Bonet L
Article. 10.3390/life13040915. 2023
Is the benefit of treating iron deficiency greater in acute heart failure with renal dysfunction?
Lopez Vilella, R. Raquel; (...); Bonet, L. Almenar
Meeting Abstract. 2023
Left bundle branch pacing versus left ventricular septal pacing as a primary procedural endpoint during left bundle branch area pacing: Evaluation of two different implant strategies.
Cano, Oscar; (...); Martinez-Dolz, Luis
Article. 10.1111/jce.16128. 2023
Long-term outcomes of extended DAPT in a real-life cohort of consecutive STEMI patients.
Tizón-Marcos H; (...); Marrugat J
Article. 10.1016/j.rec.2022.12.003. 2023
Long-term study of prevalence and evolution of tricuspid regurgitation after orthotopic heart transplantation
Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Mortality after the first hospital admission for acute heart failure de novo vs. acutely decompensated heart failure with reduced ejection fraction
Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Mortality After the First Hospital Admission for Acute Heart Failure, De Novo Versus Acutely Decompensated Heart Failure With Reduced Ejection Fraction.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.amjcard.2023.03.008. 2023
Non-invasive diagnosis of cardiac rejection using small non-coding RNAs
Gimenez-Escamilla, I.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Novel Fibrillar and Non-Fibrillar Collagens Involved in Fibrotic Scar Formation after Myocardial Infarction
Ortega, Maria; (...); Ruiz-Sauri, Amparo
Article. 10.3390/ijms25126625. 2024
Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives.
Cabrera-Romero E; (...); Garcia-Pavia P
Article. 10.1016/j.jacc.2024.02.036. 2024
Peripheral access ultrafiltration as a treatment for cardiorenal syndrome with inadequate diuretic response. Initial experience
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Letter. 10.1016/j.recesp.2022.04.017. 2023
Pharmacological Considerations during Percutaneous Treatment of Heart Failure.
Sorolla-Romero JA; (...); Sanz-Sanchez j
Article. 10.2174/0113816128284131240209113009. 2024
Plaque modification and impact on the microcirculation territory after drug-coated balloon angioplasty. The PLAMI study design
Romero, Jose Antonio Sorolla; (...); Sanchez, Jorge Sanz
Article. 10.24875/RECIC.M23000438. 2024
Plasma fibroblast activation protein is decreased in acute heart failure despite cardiac tissue upregulation
Delgado-Arija, Marta; (...); Rosello-Lleti, Esther
Article. 10.1186/s12967-024-04900-w. 2024
Practical Requirements for the Development of an Advanced Cardiorenal Unit
Almenar-Bonet, Luis; (...); Sanchez-Perez, Pilar
Review. 10.1159/000536104. 2024
Predictive potential of serum and cerebrospinal fluid biomarkers for disease activity in treated multiple sclerosis patients.
Tortosa-Carreres J; (...); Pérez-Miralles FC
Article. 10.1016/j.msard.2024.105734. 2024
Prevalence of Tricuspid Regurgitation After Orthotopic Heart Transplantation and Its Evolution in the Follow-up Period: A Long-Term Study.
Lopez-Vilella, Raquel; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.09.009. 2022
Prevalence, characteristics, and phenotype associated with tachycardiomyopathy in a cohort of patients first hospitalized for heart failure with reduced ejection fraction
Otero Garcia, O.; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 2024
Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. COMFE registry
Vega, D. Garcia; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.1187. 2024
Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. implications for their clinical management. COMFE registry
Garcia Vega, D. David; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.1187. 2024
Prognostic role of persistent angina after percutaneous revascularization in chronic coronary syndrome with altered angiography and stress CMR.
Perez-Sole, Nerea; (...); Bodi, Vicente
Article. 10.1016/j.rec.2024.09.004. 2024
Pulmonary arterial hypertension associated with pretricuspid shunts: risk profile and survival.
Calvo-Asensio, Maria; (...); Rueda Soriano, Joaquin
Article. 10.1016/j.rec.2024.04.016. 2024
Sex and clinical outcomes in new-onset heart failure.
Vicent, Lourdes; (...); Martinez-Selles, Manuel
Article. 10.1016/j.ijcard.2025.133092. 2025
Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction
Otero Garcia, O. Oscar; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.836. 2024
Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction
Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.836. 2024
Sodium-glucose cotransporter 2 inhibitors reduce cardiovascular events in acute heart failure. A real-world analysis.
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Article. 10.1016/j.ejim.2022.06.008. 2022
The central role of FAP dysregulation and cardiac fibroblast activation in heart failure patients
Rosello-Lleti, E.; (...); Tarazon, E.
Meeting Abstract. 2023
Therapeutic approach in heart failure with poor diuretic response. Peripheral ultrafiltration vs. conventional treatment
Lopez-Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Therapeutic approach in heart failure with poor diuretic response: peripheral ultrafiltration vs. conventional treatment.
López-Vilella R; (...); Almenar Bonet L
Article. 10.1002/ehf2.14386. 2023
Transcriptomic Alterations in Spliceosome Components in Advanced Heart Failure: Status of Cardiac-Specific Alternative Splicing Factors
Gimenez-Escamilla, Isaac; (...); Rosello-Lleti, Esther
Article. 10.3390/ijms25179590. 2024
Ultrafiltracion de acceso periferico como tratamiento del sindrome cardiorrenal con insuficiente respuesta diuretica. Experiencia inicial.
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Art Exhibit Review. 10.1016/j.rec.2022.04.013. 2022
Uncontrolled asistole donation. Impact on primary graft failure and heart transplantation survival
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Unveiling the prognostic journey: renal function trajectories in 'de novo' heart failure with reduced ejection fraction - insights from a cohort study and their impact on patient outcomes
Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 10.1093/eurheartj/ehae666.835. 2024
Usefulness of biomarkers to predict prognosis after heart transplant
Lopez-Vilella, Raquel; (...); Boneta, Luis Almenar
Article. 10.1016/j.rec.2024.04.019. 2024
Usefulness of short-term peripheral ambulatory ultrafiltration in heart failure refractory to diuretics. Initial experience.
Guerrero Cervera B; (...); Almenar Bonet L
Article. 10.1016/j.medcli.2023.04.008. 2023
Variation in diuretic requirement after peripheral ultrafiltration in heart failure with diuretic resistance
Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Variations in the medical treatment of heart failure during admission for decompensation
Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
What clinical parameters are associated with the prescription at hospital discharge of all medications with prognostic improvement? Analysis in de novo heart failure with reduced ejection fraction
Lopez Vilella, R. Raquel; (...); Bonet, Almenar
Meeting Abstract. 2024
What factors are associated with myocardial recovery following admission for acute heart failure? Study in patients with de novo diagnosis and reduced left ventricular ejection fraction
Donoso Trenado, V.; (...); Almenar-Bonet, L.
Meeting Abstract. 2024
Why Iron Deficiency in Acute Heart Failure Should Be Treated: A Real-World Clinical Practice Study.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.3390/life12111828. 2022