Portal de investigación
DETERMINANTES CLÍNICOS Y MOLECULARES DE RESPUESTA Y PROGRESIÓN A LA INHIBICIÓN DE KIT EN PACIENTES CON TUMORES DEL ESTROMA GASTROINTESTINAL (GIST) CON RESPUESTA PROLONGADA A IMATINIB.
Datos básicos
- Código:
- GEIS-45
- Protocolo:
- GEIS-45
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Dotación:
- Año de incio:
- 2017
- Año de finalización:
- 2022
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study.
Martínez-Trufero J; (...); Gutiérrez A
Article. 10.3390/cancers13040792. 2021
A multicenter phase 2 study of nivolumab combined with ipilimumab in patients with pediatric solid tumors in adulthood (GETHI021).
Mielgo, Xabier; (...); Garcia-Donas, Jesus
Meeting Abstract. 10.1200/JCO.2018.36.15_suppl.TPS3123. 2018
A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study
Aparicio, J; (...); on behalf of the Spanish Germ Cell Cancer Group
Article. 10.1159/000487438. 2018
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PlumX Metrics
- Citations
- Citation Indexes: 11
- Policy Citations: 2
- Captures
- Readers: 31
- Mentions
- News Mentions: 2
Aflibercept Plus FOLFIRI for Second-line Treatment of Metastatic Colorectal Cancer: Observations from the Global Aflibercept Safety and Health-Related Quality-of-Life Program (ASQoP).
Riechelmann RP; (...); Sobrero A
Article. 10.1016/j.clcc.2019.05.003. 2019
An internally validated new clinical and inflammation-based prognostic score for patients with advanced hepatocellular carcinoma treated with sorafenib
Diaz-Beveridge, R; (...); Aparicio, J
Article. 10.1007/s12094-017-1720-4. 2018
Clinical Impact of Circulating Tumor RAS and BRAF Mutation Dynamics in Patients With Metastatic Colorectal Cancer Treated With First-Line Chemotherapy Plus Anti-Epidermal Growth Factor Receptor Therapy
Maurel, J; (...); Montagut, C
Article. 10.1200/PO.18.00289. 2019
Clinicopathologic features and long-term follow-up of metastatic gastrointestinal stromal tumor (GIST) patients (pts) with durable response (> 5 years) to frontline imatinib (IM): A case-control study from GEIS
Serrano, C; (...); Broto, JM
Meeting Abstract. 2017
Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib
Serrano, C; (...); Carles, J
Article. 10.1634/theoncologist.2018-0032. 2019
Concordance of baseline RAS mutational status (ms) between tissue and cell-free DNA (cfDNA) and association with overall response rate (ORR) in first-line (1L) metastatic colorectal cancer (mCRC) patients (pts): PERSEIDA study (cohort 2) (NCT02792478)
Valladares-Ayerbes, M; (...); Vila, AL
Meeting Abstract. 10.1016/j.annonc.2021.08.976. 2021
Consensus guidelines for diagnosis, treatment and follow-up of patients with pancreatic cancer in Spain
Hidalgo, M; (...); Carrato, A
Article. 10.1007/s12094-016-1594-x. 2017
Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer.
González-Billalabeitia E; (...); Spanish Germ Cell Cancer Group and the Spanish Oncology Genitourinary Group
Article. 10.1016/j.euf.2016.07.002. 2017
Controversies in the multimodality management of locally advanced rectal cancer
Díaz Beveridge R; (...); Aparicio, J
Review. 10.1007/s12032-017-0964-8. 2017
Correction to: Recommendations for follow-up of colorectal cancer survivors.
Vera R; (...); Fernández-Cebrián JM
Article. 10.1007/s12094-019-02088-w. 2019
Correlation of RECIST, Computed Tomography Morphological Response, and Pathological Regression in Hepatic Metastasis Secondary to Colorectal Cancer: The AVAMET Study
Vera, R; (...); Viudez, A
Article. 10.3390/cancers12082259. 2020
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PlumX Metrics
- Citations
- Citation Indexes: 11
- Policy Citations: 3
- Captures
- Readers: 19
- Mentions
- Blog Mentions: 1
- News Mentions: 1
Development, Implementation and Assessment of Molecular Diagnostics by Next Generation Sequencing in Personalized Treatment of Cancer: Experience of a Public Reference Healthcare Hospital.
Simarro J; (...); Palanca S
Article. 10.3390/cancers11081196. 2019
Dynamic soluble changes in sVEGFR1, HGF, and VEGF promote chemotherapy and bevacizumab resistance: A prospective translational study in the BECOX (GEMCAD 09-01) trial
Pineda, E; (...); Maurel, J
Article. 10.1177/1010428317705509. 2017
Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies
Carreño M; (...); Graus, F
Article. 10.1016/j.eplepsyres.2016.12.010. 2017
Equity, barriers and cancer disparities: study of the Spanish Society of Medical Oncology on the access to oncologic drugs in the Spanish Regions
Salvador, J; (...); Garrido, P
Article. 10.1007/s12094-016-1535-8. 2017
Equity, barriers and cancer disparities: study of the Spanish Society of Medical Oncology on the access to oncologic drugs in the Spanish Regions (vol 19, pg 341, 2017)
Salvador J; (...); Garrido P
Correction. 10.1007/s12094-017-1628-z. 2017
ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up
Honecker, F; (...); Horwich, A
Article. 10.1093/annonc/mdy217. 2018
First-line treatment with panitumumab plus FOLFIRI in elderly patients with RAS/BRAF wild-type unresectable metastatic colorectal cancer and good performance status: OPALO trial.
Feliu, Jaime; (...); Aparicio, Jorge
Meeting Abstract. 10.1200/JCO.2018.36.15_suppl.TPS3618. 2018
Gemcitabine plus sirolimus for relapsed and progressing osteosarcoma patients after standard chemotherapy: a multicenter, single-arm phase II trial of Spanish Group for Research on Sarcoma (GEIS)
Martin-Broto, J; (...); Lopez-Pousa, A
Article. 10.1093/annonc/mdx536. 2017
Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial
Gronchi A; (...); Casali PG
Article. 10.1016/S1470-2045(17)30334-0. 2017
Human chorionic gonadotropin-positive seminoma patients: A registry compiled by the global germ cell tumor collaborative group (G3)
Seidel, C; (...); Bokemeyer, C
Article. 10.1016/j.ejca.2020.03.022. 2020
Identification Of Actionable Genetic Targets In Primary Cardiac Sarcomas
Salvador-Coloma, C; (...); de Mora, JF
Article. 10.2147/OTT.S214319. 2019
Interim analysis of a phase II study of nivolumab combined with ipilimumab in patients with pediatric solid tumors in adulthood (GETHI021).
Mielgo, X; (...); Garcia-Donas, J
Meeting Abstract. 10.1200/JCO.2019.37.15_suppl.2613. 2019
Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial.
Gonzalez-Cao M; (...); Berrocal A
Article. 10.1038/s41467-021-26572-6. 2021
Intracranial activity of encorafenib and binimetinib followed by radiotherapy in patients with BRAF mutated melanoma and brain metastasis: Preliminary results of the GEM1802/EBRAIN-MEL phase II clinical trial
Marquez-Rodas, I; (...); Berrocal, A
Meeting Abstract. 10.1016/j.annonc.2021.08.1423. 2021
Intravascular Biphasic Synovial Sarcoma: The Beneficial Role of Adjuvant Treatment Approach in the Pre-metastatic Stage.
Chicas-Sett R; (...); Tormo A
Article. 10.7759/cureus.572. 2016
Management and supportive treatment of frail patients with metastatic pancreatic cancer
Macarulla, T; (...); Hidalgo, M
Review. 10.1016/j.jgo.2018.06.005. 2019
Metastatic Colorectal Cancer. First Line Therapy for Unresectable Disease.
Aparicio J; (...); Fernandez-Montes A
Review. 10.3390/jcm9123889. 2020
Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk stratification analysis of the ISG-STS 1001 randomized trial.
Pasquali, Sandro; (...); Gronchi, Alessandro
Article. 10.1002/cncr.33895. 2022
Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups
Gronchi, A; (...); Casali, PG
Article. 10.1200/JCO.19.03289. 2020
Neoadjuvant treatment for borderline and resectable pancreatic ductal adenocarcinoma
Alvarez, R; (...); Hidalgo, M
Review. 10.1007/s12094-017-1680-8. 2017
Outcome of Men With Relapse After Adjuvant Carboplatin for Clinical Stage I Seminoma
Fischer, S; (...); Gillessen, S
Article. 10.1200/JCO.2016.69.0958. 2017
Outcome of men with relapses after adjuvant BEP for clinical stage I nonseminoma.
Fischer, Stefanie Christine; (...); Gillessen, Silke
Meeting Abstract. 10.1200/JCO.2019.37.7_suppl.510. 2019
Outcome of Men With Relapses After Adjuvant Bleomycin, Etoposide, and Cisplatin for Clinical Stage I Nonseminoma.
Fischer S; (...); Global Germ-Cell Cancer Group
Article. 10.1200/JCO.19.01876. 2020
Outcomes after neoadjuvant treatment with gemcitabine and erlotinib followed by gemcitabine-erlotinib and radiotherapy for resectable pancreatic cancer (GEMCAD 10-03 trial)
Maurel, J; (...); Fernandez-Cruz, L
Article. 10.1007/s00280-018-3682-9. 2018
Patterns of relapse and treatment outcome after active surveillance or adjuvant carboplatin for stage I seminoma: a retrospective study of the Spanish Germ Cell Cancer Group.
Aparicio, J.; (...); Germa, J. R.
Article. 10.1007/s12094-020-02393-9. 2021
Phase I/II Trial to Evaluate the Efficacy and Safety of Nanoparticle Albumin-Bound Paclitaxel in Combination With Gemcitabine in Patients With Pancreatic Cancer and an ECOG Performance Status of 2
Macarulla, T; (...); Hidalgo, M
Article. 10.1200/JCO.18.00089. 2019
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PlumX Metrics
- Citations
- Citation Indexes: 76
- Policy Citations: 2
- Captures
- Readers: 91
- Mentions
- News Mentions: 2
PIER trial: Neoadjuvant therapy with panitumumab (P) and mFOLFOX-6 in an enriched population of patients with T3 rectal adenocarcinoma of the middle third with clear mesorectal fascia.
Fernandez-Martos, Carlos; (...); Vera, Ruth
Meeting Abstract. 10.1200/JCO.2018.36.4_suppl.TPS875. 2018
Predictors of positive challenge with kiwi in children
Sabido, P; (...); Mazon, A
Meeting Abstract. 2018
Prognosis of anaemia in disseminated testicular germ cell tumours. On behalf of the Spanish Germ Cell Cancer Group (SGCCG)
Torralba, EG; (...); Billalabeitia, EG
Meeting Abstract. 2019
Prognostic factors in metastatic seminomatous germ cell tumours and elevated human chorionic gonadotrophin (HCG): A study of the G3
Seidel, C; (...); Bokemeyer, C
Meeting Abstract. 2019
Prognostic impact of LDH and HCG levels in marker-positive seminomas
Seidel, Christoph Alexander; (...); Bokemeyer, Carsten
Meeting Abstract. 2020
Prognostic role of HMG proteins in a series of 301 advanced soft tissue sarcoma patients: A Spanish Group for Sarcoma Research Study (GEIS).
Hindi, N; (...); Broto, JM
Meeting Abstract. 10.1200/JCO.2018.36.15_suppl.11573. 2018
Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients
Gonzalez-Billalabeitia, E; (...); Spanish Germ Cell Cancer Group
Article. 10.1093/jnci/djw265. 2017
Ramucirumab effectiveness in patients with advanced gastric cancer or gastro-esophageal junction adenocarcinoma in clinical practice in Spain: Sub-analysis of RAMIS study
Longo, F; (...); Sedano, MO
Meeting Abstract. 10.1016/j.annonc.2020.04.125. 2020
Randomised, open-label, phase II study of gemcitabine with and without IMM-101 for advanced pancreatic cancer
Dalgleish, AG; (...); Mudan, SS
Article. 10.1038/bjc.2016.271. 2016
Randomized phase II clinical trial to evaluate the efficacy of second line FOLFIRI-panitumumab in patients with RAS wild -type metastatic colorectal cancer who have received FOLFOXpanitumumab in first -line (BEYOND)
Aparicio, J; (...); Maurel, J
Meeting Abstract. 10.1093/annonc/mdz155.190. 2019
Randomized phase II trial of second-line FOLFIRI-panitumumab vs FOLFIRI alone in Ras wild type (wt) metastatic colorectal cancer (mCRC) patients beyond progression to first-line FOLFOX-panitumumab: BEYOND study (GEMCAD 17-01)
Aparicio, J; (...); Maurel, J
Meeting Abstract. 10.1016/j.annonc.2021.08.937. 2021
Real-life use of ramucirumab in gastric cancer in Spain: the RAMIS study.
Longo F; (...); Díaz-Cerezo S
Article. 10.2217/fon-2020-1216. 2021
Recent treatment advances in clinical stage i nonseminomatous germ cell tumors.
Letter. 10.1016/j.acuro.2020.08.014. 2021
Recommendations for follow-up of colorectal cancer survivors
Vera, R; (...); Fernandez-Cebrian, JM
Article. 10.1007/s12094-019-02059-1. 2019
Recommendations for SIR-Spheres Y-90 resin microspheres in chemotherapy-refractory/intolerant colorectal liver metastases
Aranda, E; (...); Feliu, J
Article. 10.2217/fon-2017-0220. 2017
Relevance of Reference Centers in Sarcoma Care and Quality Item Evaluation: Results from the Prospective Registry of the Spanish Group for Research in Sarcoma (GEIS).
Martin-Broto J; (...); Lopez-Pousa A
Article. 10.1634/theoncologist.2018-0121. 2019
Results of phase II randomized study of intermittent versus continuous schedule of vemurafenib plus cobimetinib in BRAF-mutated advanced melanoma.
Gonzalez-Cao, Maria; (...); Berrocal, Alfonso
Meeting Abstract. 10.1200/JCO.2021.39.15_suppl.9528. 2021
Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.
Gounder, Mrinal M.; (...); Attia, Steven
Article. 10.1200/JCO.21.01829. 2022
SEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016)
Poveda, A; (...); Martin-Broto, J
Article. 10.1007/s12094-016-1579-9. 2016
SEOM Clinical Guideline for the diagnosis and treatment of esophageal cancer (2016)
Martin-Richard M; (...); Rivera F
Article. 10.1007/s12094-016-1577-y. 2016
SEOM Clinical Guideline of localized rectal cancer (2016)
Gonzalez-Flores, E; (...); Fernandez-Martos, C
Article. 10.1007/s12094-016-1591-0. 2016
SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer (2018)
Gomez-Espana, MA; (...); Vera, R
Article. 10.1007/s12094-018-02002-w. 2019
SEOM clinical guidelines for the management of germ cell testicular cancer (2016)
Aparicio, J; (...); Garcia-del-Muro, X
Article. 10.1007/s12094-016-1566-1. 2016
SEOM clinical guidelines in gestational trophoblastic disease (2017)
Santaballa, A; (...); Garcia-Martinez, E
Article. 10.1007/s12094-017-1793-0. 2018
SEOM clinical guidelines to primary prevention of cancer (2018).
Bayo J; (...); Santaballa A
Article. 10.1007/s12094-018-02016-4. 2019
The ART-SCORE is not an effective tool for optimizing patient selection for DEB-TACE retreatment. A multicentre Spanish study
Pipa-Muniz, M; (...); Varela, M
Article. 10.1016/j.gastrohep.2017.05.009. 2017
The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3).
Seidel C; (...); Oing C
Article. 10.1007/s00345-021-03635-3. 2021
Treatment and Outcome of Patients with Stage IS Testicular Cancer: A Retrospective Study from the Spanish Germ Cell Cancer Group.
Aparicio J; (...); Terrasa J
Article. 10.1097/JU.0000000000000366. 2019
Treatment patterns of adjuvant interferon-alpha 2b for high-risk melanoma: a retrospective study of the Grupo Espanol Multidisciplinar de Melanoma - Prima study
Espinosa, E; (...); Martin-Algarra, S
Article. 10.1097/CMR.0000000000000254. 2016
Update of metastatic colorectal cancer metastases resection after FOLFIRI-aflibercept in oxaliplatin-refractory patients
Carmena, MD; (...); Martin, AM
Meeting Abstract. 10.1093/annonc/mdz155.189. 2019
Venous thromboembolism recurrence during anticoagulant treatment in gastrointestinal cancer patients
Munoz Martin, A.; (...); Angel Hernandez-Presa, M.
Meeting Abstract. 2022