Portal de investigación
ANÁLISIS DE EFICACIA, SEGURIDAD Y TOLERABILIDAD DE DARUNAVIR/COBICISTAT EN UNA COHORTE DE PACIENTES CON INFECCIÓN POR EL VIRUS DE INMUNODEFICIENCIA HUMANA EN VIDA REAL.
Datos básicos
- Código:
- SEICV-2016-1
- Protocolo:
- SEICV-2016-1
- EUDRACT:
- NCT:
- Centro:
- Dotación:
- Año de incio:
- Año de finalización:
- 2016
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects
Rosado-Sanchez, I; (...); Pacheco, YM
Article. 10.1128/AAC.00605-17. 2017
A Randomized Trial of Dolutegravir Plus Darunavir/Cobicistat as a Switch Strategy in HIV-1-Infected Patients With Resistance to at Least 2 Antiretroviral Classes.
Santos JR; (...); Paredes R
Article. 10.1093/ofid/ofad542. 2023
Adverse outcomes of first-line integrase inhibitor-based single-tablet antiretroviral regimens in the Spanish VACH cohort
Teira, R; (...); Geijo, P
Meeting Abstract. 2018
Antimicrobial stewardship programme implementation in a medical ward
Ruiz, J; (...); Poveda, JL
Article. 2018
Antiretroviral therapy without nucleoside reverse transcriptase inhibitors: dual therapy with darunavir/p and rilpivirine. Safety and efficacy in clinical practice. RIDAR 2
Arazo, P; (...); Pasquau, J
Meeting Abstract. 2018
Bictegravir/emtricitabine/tenofovir alafenamide as first-line treatment in naïve HIV patients in a rapid-initiation model of care: BIC-NOW clinical trial.
Tenorio CH; (...); Vallecillos CG
Article. 10.1016/j.ijantimicag.2024.107164. 2024
Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy
Trickey, A; (...); Antiretroviral Therapy Cohort Coll
Article. 10.1371/journal.pone.0160460. 2016
Central nervous system infections in immunocompromised patients
Castro, I; (...); Salavert, M
Article. 2018
Comparison of antiretroviral treatment initiation in HIV newly diagnosed adolescents in Spain
Torres-Fernandez, D.; (...); Navarro, M. L.
Meeting Abstract. 2019
Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors
Asensi, V; (...); Pineda, JA
Article. 10.1371/journal.pone.0221598. 2019
Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir/Abacavir/Lamivudine in Antiretroviral-Naive Adults (SYMTRI): A Multicenter Randomized Open-Label Study (PReEC/RIS-57).
Podzamczer D; (...); Moreno S
Article. 10.1093/ofid/ofab595. 2022
Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy
Gras, L; (...); Antiretroviral Therapy Cohort
Article. 10.1097/QAI.0000000000001913. 2019
Differences in epidemiology and mortality between men and women with HIV infection in the CoRIS cohort from 2004 to 2014.
Muñoz Hornero C; (...); Pérez-Elías MJ
Article. 10.1016/j.eimc.2020.05.021. 2021
Differences in epidemiology and mortality between men and women with HIV infection in the CoRIS cohort from 2004 to 2014.
Muñoz Hornero C; (...); Pérez-Elías MJ
Article. 10.1016/j.eimce.2021.07.003. 2021
DOLAVI Real-Life Study of Dolutegravir Plus Lamivudine in Naive HIV-1 Patients (48 Weeks).
Hidalgo-Tenorio, Carmen; (...); Garcia-Vallecillos, Coral
Article. 10.3390/v14030524. 2022
Dolutegravir plus rilpivirine: benefits beyond viral suppression: DORIPEX retrospective study.
Troya, Jesus; (...); Buzon, Luis
Article. 10.1097/MD.0000000000029252. 2022
Dynamics of creatinine estimated glomerular filtration rate using one or more antiretrovirals that inhibit creatinine tubular secretion.
Perez Elias MJ; (...); Martinez E
Article. 10.1093/jac/dkaa547. 2021
Early Detection of Cancer and Precancerous Lesions in Persons with HIV through a Comprehensive Cancer Screening Protocol.
Gutierrez, Felix; (...); Masia, Mar
Article. 10.1093/cid/ciae359. 2024
Effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide in HIV late presenters
Corona, Diana; (...); Rivero, Antonio
Article. 10.1016/j.ijantimicag.2023.107016. 2024
Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study.
Santos JR; (...); Paredes R
Article. 10.3389/fcimb.2023.1187999. 2023
Effectiveness and tolerability of dolutegravir and abacavir/lamivudine administered as two separate pills compared to their equivalent single-tablet regimen in treatment-naive and treatment-experienced patients
Suarez-Garcia, I.; (...); Jarrin, I.
Meeting Abstract. 2021
Effectiveness, safety/tolerability of OBV/PTV/r DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice - Vie-KinD study.
Londoño MC; (...); García-Buey L
Article. 10.1371/journal.pone.0221567. 2019
Effectiveness, safety/tolerability of OBV/PTV/r +/- DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb/V and dialysis in Spanish clinical practice - preliminary data Vie-KinD study
Londono, MC; (...); De Alvaro, C
Meeting Abstract. 10.1016/S0168-8278(17)31920-7. 2017
Efficacy and safety of dolutegravir/rilpivirine in real-world clinical practice. GeSIDA study 1119.
Palacios, R.; (...); Santos, J.
Article. 10.1111/hiv.13489. 2023
eGFR-EPI changes among HIV patients who switch from F/TDF to F/TAF while maintaining the same third agent in the Spanish VACH cohort
Teira, R; (...); Espinosa, N
Article. 10.1080/25787489.2021.1955197. 2021
Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019.
Fanciulli C; (...); González Garcia J
Article. 10.1111/hiv.13229. 2022
Eradication of Hepatitis C Virus and Non-Liver-Related Non-Acquired Immune Deficiency Syndrome-Related Events in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection
Berenguer, J; (...); GESIDA HIV
Article. 10.1002/hep.29071. 2017
Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2.
Ruiz-Rodriguez P; (...); Coscolla M
Article. 10.1128/mBio.02315-21. 2021
Evolving understanding of cardiovascular, cerebrovascular and peripheral arterial disease in people living with HIV and role of novel biomarkers. A study of the Spanish CoRIS cohort, 2004-2015
Masia, M; (...); Gutierrez, F
Article. 10.1371/journal.pone.0215507. 2019
Factors associated with late presentation for HIV care in adolescents in Spain
Epalza, Cristina; (...); Luisa Navarro, Maria
Article. 10.1111/hiv.13407. 2022
Factors associated with the number of drugs in darunavir/cobicistat regimens.
Martinez E; (...); Perez-Elias MJ
Article. 10.1093/jac/dkz399. 2020
Hepatocellular carcinoma after sustained virological response with interferon-free regimens in HIV/hepatitis C virus-coinfected patients
Merchante, N; (...); GEHEP-002 Study Grp
Article. 10.1097/QAD.0000000000001809. 2018
High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control
Gutierrez-Rivas, M; (...); ECRIS Integrated Spanish AIDS Res
Article. 10.3389/fimmu.2018.01399. 2018
HIV/HBV coinfection in Spain: prevalence and clinical characteristics
Perez Latorre, L.; (...); Gonzalez-Garcia, J.
Meeting Abstract. 2019
HIV/HBV coinfection: temporal trends and patient characteristics, Spain, 2002 to 2018
Perez-Latorre, L; (...); Gonzalez-Garcia, J
Article. 10.2807/1560-7917.ES.2021.26.25.2000236. 2021
HIV-coinfected patients respond worse to direct-acting antiviral-based therapy against chronic hepatitis C in real life than HCV-monoinfected individuals: a prospective cohort study
Neukam, K; (...); Pineda, JA
Article. 10.1080/15284336.2017.1330801. 2017
Human Immunodeficiency Virus/Hepatits C Virus Coinfection in Spain: Elimination Is Feasible, but the Burden of Residual Cirrhosis Will Be Significant
Berenguer, J; (...); GeSIDA 8514 Study Grp
Article. 10.1093/ofid/ofx258. 2018
Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection.
Masiá M; (...); Martínez E
Article. 10.1186/s13063-021-05777-6. 2021
Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection (vol 22, 851, 2021)
Masia, M.; (...); Martinez, E.
Correction. 10.1186/s13063-023-07655-9. 2023
Impact of HIV on the survival of hepatocellular carcinoma in hepatitis C virus-infected patients
Merchante, N; (...); Pineda, JA
Article. 10.1097/QAD.0000000000002578. 2020
Improvements in Patient-Reported Outcomes After 12 Months of Maintenance Therapy With Cabotegravir+Rilpivirine Long-Acting Compared With Bictegravir/Emtricitabine/Tenofovir Alafenamide in the Phase 3b SOLAR Study.
Mussini, Cristina; (...); van Wyk, Jean
Article. 10.1007/s10461-024-04490-0. 2024
Integrase strand-transfer inhibitors for treatment of early HIV infection A case series
Teira, R; (...); Montero, M
Article. 10.1097/MD.0000000000016866. 2019
Interferon-free therapy for treating hepatitis C virus in difficult-to-treat HIV-coinfected patients
Minguez, C; (...); COINFECOVA-2 Study Grp
Article. 10.1097/QAD.0000000000001699. 2018
IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors.
Álvarez H; (...); Poveda E
Article. 10.3389/fimmu.2023.1257725. 2023
Is Visceral Leishmaniasis Different in Immunocompromised Patients Without Human Immunodeficiency Virus? A Comparative, Multicenter Retrospective Cohort Analysis
Ramos, JM; (...); Portilla, J
Article. 10.4269/ajtmh.16-0940. 2017
Knowledge, attitudes and practices in HIV-related chronic inflammation and cardiovascular risk in Spain
Serrano-Villar, Sergio; (...); de Isla, Leopoldo Perez
Article. 10.1016/j.eimc.2023.07.005. 2024
Knowledge, attitudes and practices in HIV-related chronic inflammation and cardiovascular risk in Spain.
Serrano-Villar, Sergio; (...); Perez de Isla, Leopoldo
Article. 10.1016/j.eimce.2023.07.009. 2023
Laboral Cranio-Facial Cellulitis with Perichondritis and External Otitis, A Case Report
Moreno, Eloy Sempere, Barcelo, Santos Ibanez, Alonso, Marta Montero
Editorial Material. 10.1016/j.eimc.2024.02.008. 2024
Laboral cranio-facial cellulitis with perichondritis and external otitis, a case report.
Sempere Moreno, Eloy, Ibanez Barcelo, Santos, Montero Alonso, Marta
Case Reports. 10.1016/j.eimce.2024.04.004. 2024
Lack of impact of protease inhibitor resistance-associated mutations on the outcome of HIV-1-infected patients switching to darunavir-based dual therapy
Vizcarra, P; (...); Moral, SD
Article. 10.1080/23744235.2019.1694696. 2020
Long or complicated mpox in patients with uncontrolled HIV infection.
Corma-Gómez A; (...); Macías J
Article. 10.1002/jmv.29511. 2024
Long term follow-up in HCV infected patients with end stage chronic kidney disease after DAA therapy
Martinez-Camprecios, J; (...); Buti, M
Meeting Abstract. 2021
Long-term evolution in liver disease markers and immune and lipid profiles in vertically HIV/HCV-coinfected youths with sustained viral response after direct-acting antivirals therapy.
Tarancon-Diez, Laura; (...); Muñoz-Fernández MÁ
Article. 10.1016/j.biopha.2023.114587. 2023
Long-term follow-up of HCV-infected patients with end-stage chronic kidney disease after sustained virological response with direct-acting antiviral therapy
Martinez-Camprecios, Joan; (...); Buti, Maria
Article. 10.1016/j.gastrohep.2022.12.004. 2023
Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV( vol 106, pg 136, 2024)
Pelchen-Matthews, Annegret; (...); Wyatt, Christina M.
Correction. 10.1016/j.kint.2024.10.002. 2024
Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV.
Pelchen-Matthews, Annegret; (...); Wyatt, Christina M.
Article. 10.1016/j.kint.2024.04.010. 2024
Losses to follow-up of HIV-infected people in the Spanish VACH cohort over the period between 2013 and 2014: The importance of sociodemographic factors
Teira, R; (...); Grp Estudio VACH
Article. 10.1016/j.eimc.2018.09.008. 2019
Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients
Merchante, N; (...); GEHEP-002 Study Grp
Article. 10.1097/QAD.0000000000002065. 2019
Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count
Ruiz-de-Leon, MJ; (...); Sierra, O
Article. 10.1016/j.jmii.2018.07.007. 2019
Maintenance of virologic suppression and improvement in comorbidities after simplification to raltegravir plus boosted darunavir among treatment-experienced HIV-infected patients
Casado, JL; (...); De Santiago, AD
Article. 10.1177/0956462419896478. 2020
Mild profile improvement of immune biomarkers in HIV/HCV-coinfected patients who removed hepatitis C after HCV treatment: A prospective study
Garcia-Broncano, P; (...); GESIDA 3603b Study Grp
Article. 10.1016/j.jinf.2019.09.020. 2020
Mitochondrial haplogroup H is related to CD4+T cell recovery in HIV infected patients starting combination antiretroviral therapy
Medrano, LM; (...); Spanish AIDS Res Network Project
Article. 10.1186/s12967-018-1717-y. 2018
Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV.
Bernardino, Jose I.; (...); Rodes, Berta
Article. 10.3390/microorganisms11071818. 2023
Mortality in Perinatally HIV-infected Adolescents After Transition to Adult Care in Spain.
Berzosa Sánchez A; (...); Ramos Amador JT
Article. 10.1097/INF.0000000000003009. 2021
Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation
Lopez-Medrano, F; (...); Swiss Transplant Cohort Study STCS
Article. 10.1016/j.cmi.2017.06.016. 2018
Observational study to evaluate discontinuation of monotherapy with cobicistat-boosted darunavir in patients with human immunodeficiency virus
Solana-Altabella, Antonio; (...); Poveda-Andres, Jose Luis
Article. 10.1097/MD.0000000000032208. 2022
Outcomes by sex following treatment initiation with darunavir/cobicistat in a large Spanish cohort of the CODAR study (GeSIDA 9316)
Perez Elias, MJ; (...); CODAR Study Grp
Article. 10.1093/jac/dkz254. 2019
Prevalence of people living with multidrug-resistant HIV and limited treatment options in Spain.
Llibre, Josep M; (...); Alcantara, Felipe Rodriguez
Article. 10.1111/hiv.13650. 2024
Primary resistance to integrase strand transfer inhibitors in Spain using ultrasensitive HIV-1 genotyping.
Casadellà M; (...); Noguera-Julian M
Article. 10.1093/jac/dkaa349. 2020
Prospective study for the early detection of lung carcinoma in patients with HIV infection (GESIDA study 8815).
Valencia ME; (...); González J
Article. 10.1016/j.eimce.2024.05.005. 2024
Psychological distress in women and men living with HIV in Spain: a cross-sectional telephone survey
Garriga, C; (...); Rodriguez-Arenas, MA
Article. 10.1136/ebmental-2019-300138. 2020
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR
Vigon, L; (...); Esteban, H
Article. 10.1038/s41598-019-48592-5. 2019
Real world effectiveness of standard of care triple therapy versus two-drug combinations for treatment of people living with HIV.
Teira, Ramon; (...); Berenguer, Juan
Article. 10.1371/journal.pone.0249515. 2021
Real-life experience with sorafenib for the treatment of hepatocellular carcinoma in HIV-infected patients
Merchante, N; (...); GEHEP-002 Study Group
Article. 10.1097/QAD.0000000000001293. 2017
Real-world persistence of E/C/F/TAF versus DTG+ABC/3TC regimens for treatment of HIV in a large Spanish cohort: VACH
Teira, R; (...); Gutierrez, M
Meeting Abstract. 2018
Reasons for noncompliance with the national guidelines for initial antiretroviral therapy of HIV-infected patients in Spain, 2010-2015
Gonzalez, J; (...); Cohort Spanish HIV Res Network Co
Article. 10.1016/j.eimc.2019.02.007. 2019
Reproductive history before and after HIV diagnosis: A cross-sectional study in HIV-positive women in Spain
Hernando, V; (...); and CoRIS
Article. 10.1097/MD.0000000000005991. 2017
Response to direct acting antivirals in vertically HIV/HCV co-infected youths
Carrasco, I; (...); CoRISpe-Spanish Natl Cohort
Meeting Abstract. 2019
Response to direct-acting antivirals for hepatitis C treatment in vertically HIV/HCV co-infected patients
Carrasco, I; (...); Navarro, ML
Article. 10.1111/jvh.13308. 2020
Shorter Time to Discontinuation Due to Treatment Failure in People Living with HIV Switched to Dolutegravir Plus Either Rilpivirine or Lamivudine Compared with Integrase Inhibitor-Based Triple Therapy in a Large Spanish Cohort
Teira, Ramon; (...); Curran, Adria
Article. 10.1007/s40121-022-00630-y. 2022
Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies
Trickey, A, Montero, M
Article. 10.1016/S2352-3018(17)30066-8. 2017
Switching to a dual regimen with the combination of boosted darunavir plus raltegravir in severely experienced patients: a multicentre, retrospective analysis
Casado, J; (...); de Santiago, AD
Meeting Abstract. 2018
Switching to bictegravir/ emtricitabine/tenofovir alafenamide plus darunavir/cobicistat in heavily antiretroviralexperienced, virologically suppressed HIV-infected adults receiving complex regimens: 48-week analysis
Podzamczer, D.; (...); Rivero, A.
Meeting Abstract. 2023
Switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat in heavily antiretroviral-experienced, virologically suppressed HIV-infected adults receiving complex regimens.
Podzamczer, Daniel; (...); Rivero, Antonio
Article. 10.1093/jac/dkad285. 2023
The algorithm used for the interpretation of doravirine transmitted drug resistance strongly influences clinical practice and guideline recommendations.
Guerrero-Beltrán C; (...); Moreno S
Article. 10.1093/jac/dkaa009. 2020
Thymic Function Failure Is Associated With Human Immunodeficiency Virus Disease Progression
Ferrando-Martinez S; (...); Ruiz-Mateos E
Article. 10.1093/cid/cix095. 2017
Transmitted drug resistance to antiretroviral drugs in Spain during the period 2019-2021.
Vinuela, Laura; (...); Garcia, Federico
Article. 10.1002/jmv.29287. 2023
Unplanned pregnancies and social and partner support during pregnancy in Spanish women living with HIV.
Ruiz-Alguero, Marta; (...); Jarrin, Inma
Article. 10.1111/hiv.13469. 2023
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
Jimenez-Sousa, MA; (...); LTNPs Cohort
Article. 10.3390/jcm8030311. 2019
Very low level viraemia and risk of virological failure in treated HIV-1-infected patients
Teira, R; (...); VACH Study Group
Article. 10.1111/hiv.12413. 2017