ENSAYO CLÍNICO FASE III ALEATORIZADO Y CIEGO SOBRE EL USO DE TOBRAMICINA INHALADA COMPARADA CON PLACEBO EN PACIENTES SOMETIDOS A VENTILACIÓN MECÁNICA Y COLONIZADOS POR BACTERIAS GRAM NEGATIVAS PARA COMPROBAR SU EFICACIA EN LA REDUCCIÓN DEL TIEMPO DE VENTILACIÓN MECÁNICA.

Datos básicos

Código:
BIOTOB
Protocolo:
BIOTOB
EUDRACT:
2015-001109-15
NCT:
Centro:
HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
Dotación:
Año de incio:
2017
Año de finalización:
2020
ENSAYO CLÍNICO

Documentos

  • No hay documentos

Participantes

Grupos

Financiadores - Promotores

FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA

Resultados del Ensayo Clínico


[Management of infectious complications associated with coronavirus infection in severe patients admitted to ICU].

Estella, Angel; (...); Zaragoza, Rafael

Article. 10.1016/j.medin.2021.04.007. 2021

  • Open Access.

[Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units].

Vidal-Cortes, Pablo; (...); Crespo, Rafael Zaragoza

Article. 10.1016/j.medin.2021.08.011. 2021

  • Open Access.

[Translated article] National registry and analysis of pharmaceutical interventions in critical care units: PHARMACRITIC study.

Cerezuela, Maria Martin; (...); Chiva, Esther Domingo

Article. 10.1016/j.farma.2024.10.003. 2024

  • Open Access.

Acceptance and validity of the methods used to implement a competency based medical education programme in an Intensive Care Department of a teaching referral center.

Castellanos-Ortega, A.; (...); Garcia-Ros, R.

Article. 10.1016/j.medin.2019.12.007. 2021


Acceptance and validity of the methods used to implement a competency based medical education programme in an Intensive Care Department of a teaching referral center.

Castellanos-Ortega A; (...); García-Ros R

Article. 10.1016/j.medine.2019.12.011. 2021


Activities of the clinical pharmacist in the intensive care units.

Becerril-Moreno F; (...); Cobo-Sacristán S

Article. 10.1016/j.farma.2024.09.004. 2024

  • Open Access.

Acute cellular rejection versus recurrent hepatitis C after liver transplantation: Clinical and pathological features driving a rational diagnostic approach

de la Peña-Moral JM; (...); Parrilla P

Article. 10.1111/hepr.12369. 2015


Acute coronary syndrome due to a giant right coronary artery aneurysm

Villarreal, E, Jannone, R, Castellanos, A

Editorial Material. 10.1016/j.medin.2016.09.002. 2018


Acute respiratory distress syndrome due to COVID-19. Clinical and prognostic features from a medical Critical Care Unit in Valencia, Spain.

Ramírez P; (...); Castellanos Á

Article. 10.1016/j.medin.2020.06.015. 2021

  • Open Access.

Adoptive transfer of ex-vivo expanded SARS-CoV-2-specific Cytotoxic Lymphocytes: a viable strategy for COVID-19 immunosuppressed patients?

Guerreiro M; (...); Piñana JL

Article. 10.1111/tid.13602. 2021

  • Open Access.

Aflibercept in exudative age related macular degeneration refractory to ranibizumab.

Ruiz Ramos J; (...); Gallego-Pinazo R

Article. 10.1016/j.oftal.2015.07.018. 2015


An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital

Ruiz-Gaitan, A; (...); Peman, J

Article. 10.1111/myc.12781. 2018

  • Open Access.

Analysis of treatment failure with standardand high dose of tigecycline in critically ill patients with multidrug resistant bacteria.

JESÚS RUIZ RAMOS; (...); PAULA RAMÍREZ GALLEYMORE

Article. 2017


Anti-endotoxin antibodies consumption in cardiovascular collapse: Pathophysiological concerns.

Villarreal, E.; (...); Vila, J.

Article. 10.1016/j.medine.2022.04.019. 2022


Antimicrobial Pharmacokinetics and Pharmacodynamics in Critical Care: Adjusting the Dose in Extracorporeal Circulation and to Prevent the Genesis of Multiresistant Bacteria.

Ruiz-Ramos, Jesus, Gras-Martin, Laura, Ramirez, Paula

Article. 10.3390/antibiotics12030475. 2023

  • Open Access.

Antimicrobial stewardship in hospitals: Expert recommendation guidance document for activities in specific populations, syndromes and other aspects (PROA-2) from SEIMC, SEFH, SEMPSPGS, SEMICYUC and SEIP.

Cercenado, Emilia; (...); Retamar-Gentil, Pilar

Practice Guideline. 10.1016/j.eimce.2022.05.013. 2023


Antimicrobial stewardship in hospitals: Expert recommendation guidance document for activities in specific populations, syndromes and other aspects (PROA-2) from SEIMC, SEFH, SEMPSPGS, SEMICYUC and SEIP

Cercenado, Emilia; (...); Retamar-Gentil, Pilar

Editorial Material. 10.1016/j.eimc.2022.05.005. 2023


Antimicrobial stewardship programme implementation in a medical ward

Ruiz, J; (...); Poveda, JL

Article. 2018


Antimicrobial stewardship programme in critical care medicine: A prospective interventional study

Ruiz, J; (...); Catellanos, A

Article. 10.1016/j.medin.2017.07.002. 2018


Antimicrobial stewardship programs in the critical care setting

Ruiz-Ramos J, Ramirez P

Editorial Material. 10.1016/j.medin.2016.04.010. 2016


Antimicrobial stewardship programs in the intensive care unit in patients with infections caused by multidrug-resistant gram-negative bacilli

Ramos, J. Ruiz, Galleymore, P. Ramirez

Article. 10.1016/j.medin.2022.07.007. 2023


Antimicrobial stewardship programs in the Intensive Care Unit in patients with infections caused by multidrug-resistant Gram-negative bacilli.

Ruiz-Ramos J, Ramírez P

Article. 10.1016/j.medine.2022.09.004. 2022


Antisepsis for blood culture extraction. Blood culture contamination rate

Galleymore, PR, Sahuquillo, MG

Article. 10.1016/j.medin.2018.08.007. 2019


Bayesian pharmacokinetic individualization of prophylaxis with recombinant factor VIII in severe or moderate hemophilia A

Megias-Vericat, JE; (...); Bonanad, S

Meeting Abstract. 2018


Bayesian pharmacokinetic-guided prophylaxis with recombinant factor VIII in severe or moderate haemophilia A

Megias-Vericat, JE; (...); Poveda, JL

Article. 10.1016/j.thromres.2018.12.027. 2019


Beyond the Pandemic: The Value of Antimicrobial Stewardship

Kanj, Souha S., Ramirez, Paula, Rodrigues, Camilla

Article. 10.3389/fpubh.2022.902835. 2022

  • Open Access.

Biomarker kinetics in the prediction of VAP diagnosis: results from the BioVAP study

Póvoa P; (...); Artigas A

Article. 10.1186/s13613-016-0134-8. 2016

  • Open Access.

Biomarkers in pulmonary infections: a clinical approach.

Povoa, Pedro; (...); Kalil, Andre C

Article. 10.1186/s13613-024-01323-0. 2024

  • Open Access.

Biomarkers in the ICU: less is more? Yes.

Huang, David T., Ramirez, Paula

Editorial Material. 10.1007/s00134-020-06049-8. 2021

  • Open Access.

Biomarkers kinetics in the assessment of ventilator-associated pneumonia response to antibiotics - results from the BioVAP study

Povoa, P; (...); Artigas, A

Article. 10.1016/j.jcrc.2017.05.007. 2017


Blood culture contamination rate in an intensive care setting: Effectiveness of an education-based intervention

Ramirez P; (...); Bonastre J

Article. 10.1016/j.ajic.2015.04.183. 2015


Carbapenemase-producing Pseudomonas aeruginosa in Spain: interregional dissemination of the high-risk clones ST175 and ST244 carrying bla(VIM-2), bla(VIM-1), bla(IMP-8), bla(VIM-20) and bla(KPC-2)

Perez-Vazquez, M; (...); Oteo-Iglesias, J

Article. 10.1016/j.ijantimicag.2020.106026. 2020


Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2

Arana, DM; (...); Spanish Antibiotic Resistance Surveillance Programme Collaborating Group

Article. 10.1093/jac/dkx325. 2017

  • Open Access.

Case report: Parvimonas micra infective endocarditis.

García-Hita M; (...); Frasquet-Artes J

Letter. 10.1016/j.eimc.2020.01.012. 2020


Cefiderocol pharmacokinetics in critically ill patients undergoing ECMO support.

Marín-Cerezuela M; (...); Ramirez P

Letter. 10.1186/s13054-024-05126-4. 2024

  • Open Access.

Ceftaroline versus standard therapy for pneumococcal meningitis in critically ill patients.

Martin-Cerezuela, M; (...); Galleymore, P R

Article. 10.1016/j.medin.2021.05.011. 2021


Ceftaroline versus standard therapy for pneumococcal meningitis in critically ill patients.

Martín-Cerezuela M; (...); Galleymore PR

Article. 10.1016/j.medine.2021.05.007. 2022


Ceftazidime, carbapenems, or piperacillin-tazobactam as single definitive therapy for Pseudomonas aeruginosa bloodstream infection - a multi-site retrospective study.

Babich T; (...); Yahav D

Article. 10.1093/cid/ciz668. 2020


Ceftolozane/Tazobactam Dosing Requirements Against Pseudomonas aeruginosa Bacteremia.

Ruiz J; (...); Ramirez P

Article. 10.1177/1559325819885790. 2020

  • Open Access.

Clinical benefits of a Bayesian model for plasma-derived factor VIII/VWF after one year of pharmacokinetic-guided prophylaxis in severe/moderate hemophilia A patients

Megias-Vericat, JE; (...); Poveda, JL

Article. 10.1016/j.thromres.2021.07.009. 2021


Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit

Garnacho-Montero, J; (...); GETGAG Study Grp

Article. 10.1016/j.jcrc.2018.08.017. 2018


Clinical characteristics, risk factors and management of patients with inflammatory bowel disease and hidradenitis suppurativa: a nationwide multicenter study of the GETECCU ENEIDA registry

Madero Velazquez, L.; (...); Gutierrez-Casbas, A.

Meeting Abstract. 2024

  • Open Access.

Clinical Effectiveness of Influenza Vaccination After Allogeneic Hematopoietic Stem Cell Transplantation: A Cross-sectional, Prospective, Observational Study

Pinana, JL; (...); Navarro, D

Article. 10.1093/cid/ciy792. 2019

  • Open Access.

Clinical significance of Pneumocystis jirovecii DNA detection by real-time PCR in hematological patient respiratory specimens.

Piñana JL; (...); Navarro D

Letter. 10.1016/j.jinf.2020.01.001. 2020

  • Open Access.

CMV REACTIVATIONS IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT FROM HLA-MATCHED AND HAPLOIDENTICAL DONORS WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE.

Chorão P; (...); Sanz J

Article. 10.1016/j.jtct.2024.01.082. 2024

  • Open Access.

Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial

Cisneros, JM; (...); Magic Bullet Working Grp WP1

Article. 10.1186/s13054-019-2627-y. 2019

  • Open Access.

Combatting resistance in intensive care: the multimodal approach of the Spanish ICU "Zero Resistance" program

Montero JG; (...); García MS

Review. 10.1186/s13054-015-0800-5. 2015

  • Open Access.

Combination versus monotherapy as definitive treatment for Pseudomonas aeruginosa bacteraemia: a multicentre retrospective observational cohort study

Babich, T; (...); Yahav, D

Article. 10.1093/jac/dkab134. 2021


Common seasonal respiratory virus infections in allogeneic stem cell transplant recipients during the SARS-COV-2 pandemic.

De La Puerta R; (...); Piñana JL

Article. 10.1038/s41409-021-01319-5. 2021

  • Open Access.

Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation.

Montoro J; (...); Piñana JL

Article. 10.1038/s41409-020-0943-0. 2020

  • Open Access.

Community-acquired respiratory virus lower respiratory tract disease in allogeneic stem cell transplantation recipient: Risk factors and mortality from pulmonary virus-bacterial mixed infections

Pinana, JL; (...); Navarro, D

Article. 10.1111/tid.12926. 2018

  • Open Access.

Comparison of pharmacokinetic estimates using generic and specific population pharmacokinetic models of plasma-derived factor VIII/VWF using WAPPS-Hemo

Megias-Vericat, JE; (...); Poveda, JL

Meeting Abstract. 2020


Cost-effectiveness analysis of implementing an antimicrobial stewardship program in critical care units

Ruiz-Ramos, J; (...); Ramirez, P

Article. 10.1080/13696998.2017.1311903. 2017


Current aspects in sepsis approach. Turning things around

Javier Candel, Francisco; (...); Vidal, Pablo

Review. 2018


Current aspects in sepsis approach. Turning things around.

Candel FJ; (...); Vidal P

Article. 2018


Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults.

Vidal-Cortes, Pablo; (...); Zaragoza, Rafael

Review. 10.3390/antibiotics11091160. 2022

  • Open Access.

Cytomegalovirus DNA load monitoring in stool specimens for anticipating the occurrence of intestinal acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: Is it of any value?

Bueno F; (...); Navarro D

Article. 10.1111/tid.13440. 2020


Cytomegalovirus DNAemia in hematological patients undergoing CD19-directed CAR-T cell therapy: should it be systematically monitored?

Solano de la Asuncion, Carlos; (...); Navarro, David

Letter. 10.1016/j.cmi.2023.05.010. 2023


Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae

Rechenberger, J; (...); Kuster, B

Article. 10.3390/proteomes7010002. 2019

  • Open Access.

Daily bathing strategies and cross-transmission of multidrug-resistant organisms: Impact of chlorhexidine-impregnated wipes in a multidrug-resistant gram-negative bacteria endemic intensive care unit

Ruiz, J; (...); Castellanos-Ortega, A

Article. 10.1016/j.ajic.2017.06.029. 2017


Decolonization strategies against multidrug resistant organisms in the ICU.

Póvoa P, Ramirez P, Blot S

Editorial Material. 10.1007/s00134-024-07360-4. 2024

  • Open Access.

Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients A Randomized Clinical Trial

Wittekamp, BH; (...); Bonten, MJM

Article. 10.1001/jama.2018.13765. 2018

  • Open Access.

Design of a new mortality indicator in acute coronary syndrome on admission to the Intensive Care Unit.

Lozano Gomez, Herminia; (...); Araiz Burdio, Juan Jose

Article. 10.1016/j.medine.2023.03.008. 2023


Design of a new mortality indicator in acute coronary syndrome on admission to the Intensive Care Unit

Gomez, Herminia Lozano; (...); Araiz Burdio, Juan Jose

Article. 10.1016/j.medin.2023.02.002. 2023

  • Open Access.

Detection and treatment of Candida auris in an outbreak situation: risk factors for developing colonization and candidemia by this new species in critically ill patients

Ruiz-Gaitan, Alba; (...); Peman, Javier

Article. 10.1080/14787210.2019.1592675. 2019


Detection of plasmid-mediated colistin resistance, mcr-1 gene, in Escherichia coli isolated from high-risk patients with acute leukemia in Spain

Lalaoui, R; (...); Rolain, JM

Article. 10.1016/j.jiac.2019.03.007. 2019


Determination of meropenem in endotracheal tubes by in-tube solid phase microextraction coupled to capillary liquid chromatography with diode array detection

Hakobyan, L; (...); Campins-Falco, P

Article. 10.1016/j.jpba.2018.01.006. 2018


Diagnosis and treatment of catheter-related bloodstream infection: Clinical guidelines of the Spanish Society of Infectious Diseases and Clinical Microbiology and (SEIMC) and the Spanish Society of Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC).

Chaves F; (...); Valles J

Article. 10.1016/j.medin.2017.09.012. 2018

  • Open Access.

Disseminated toxoplasma infection after hematopoietic stem cell transplantation with myositis and encephalitis.

Asensi Cantó P; (...); Guerreiro M

Article. 10.1111/tid.14067. 2023

  • Open Access.

Distal Access Catheter Improves Balloon Guide and Stent Retriever Thrombectomy Outcomes in Nonagenarians.

Puig, Josep; (...); Blasco, Jordi

Article. 10.1111/jon.70012. 2025


Echinocandins Compared to Fluconazole for Candidemia of a Urinary Tract Source: A Propensity Score Analysis

Cuervo G; (...); Carratalà J

Article. 10.1093/cid/cix033. 2017

  • Open Access.

Effect of pharmacokinetic/pharmacodynamic ratio on tigecycline clinical response and toxicity in critically ill patients with multidrug-resistant Gram-negative infections

Ruiz, J; (...); Castellanos-Ortega, A

Article. 10.1177/2050312120958897. 2020

  • Open Access.

Efficacy and Experience of Bacteriophages in Biofilm-Related Infections.

Gordon, Monica, Ramirez, Paula

Article. 10.3390/antibiotics13020125. 2024

  • Open Access.

Emergence of NDM-producing Klebsiella pneumoniae and Escherichia coli in Spain: phylogeny, resistome, virulence and plasmids encoding blaNDM-like genes as determined by WGS.

Pérez-Vázquez M; (...); Spanish NDM Study Group

Article. 10.1093/jac/dkz366. 2019


Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development. (2011-2016): KAWA-RACE study group

Fernandez-Cooke, E; (...); KAWA-RACE Study Grp

Article. 10.1371/journal.pone.0215665. 2019

  • Open Access.

Epidemiology and clinical features caused by Candida auris in the setting of a prolonged outbreak

Ruiz, AC; (...); Peman, J

Meeting Abstract. 2017

  • Open Access.

Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia.

Ceccato, Adrian; (...); Artigas, Antonio

Article. 10.3390/biomedicines11102676. 2023

  • Open Access.

Executive summary: Diagnosis and Treatment of Catheter-Related Bloodstream Infection: Clinical Guidelines of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) and the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC)

Chaves, F; (...); Valles, J

Article. 10.1016/j.eimc.2017.10.019. 2018

  • Open Access.

Fecal Calprotectin Pretreatment and Induction Infliximab Levels for Prediction of Primary Nonresponse to Infliximab Therapy in Crohn's Disease

Beltran, B; (...); Nos, P

Article. 10.1159/000492626. 2019


Fosfomycin in infections caused by multidrug-resistant Gram-negative pathogens.

Ruiz Ramos J, Salavert Lletí M

Article. 2019


Four cases of unexpected severe community-acquired pneumonia aetiology: Group A Streptococcus pyogenes disruption

Talavera, Monica; (...); Ramirez, Paula

Letter. 10.1016/j.medin.2023.04.013. 2023


Four cases of unexpected severe community-acquired pneumonia aetiology: Group A Streptococcus pyogenes disruption.

Talavera, Monica; (...); Ramirez, Paula

Case Reports. 10.1016/j.medine.2023.05.004. 2023


From MIC creep to MIC decline: Staphylococcus aureus antibiotic susceptibility evolution over the last 4 years

Ruiz J; (...); Ramirez P

Letter. 10.1016/j.cmi.2016.05.007. 2016

  • Open Access.

From starting mechanical ventilation to ventilator-associated pneumonia, choosing the right moment to start antibiotic treatment

Ramirez P; (...); Torres A

Article. 10.1186/s13054-016-1342-1. 2016

  • Open Access.

Fungal co-infection in COVID-19 patients: Should we be concerned?

Pemán J; (...); Quindós G

Review. 10.1016/j.riam.2020.07.001. 2020


Genetic Characterization of Extensively Drug-Resistant Shigella sonnei Infections, Spain, 2021-2022

Jacqueline, Camille; (...); Herrera-Leon, Silvia

Article. 10.3201/eid2911.221746. 2023

  • Open Access.

Haemodialysis significantly reduces serum levetiracetam levels inducing epileptic seizures: Case report

Company-Albir, MJ; (...); Poveda, JL

Article. 10.1111/jcpt.12568. 2017


High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous $\beta$-Lactams.

Djukovic, Ana; (...); Ubeda, Carles

Article. 2020


High heterogeneity of multidrug-resistant Enterobacteriaceae fecal levels in hospitalized patients is partially driven by intravenous beta-lactams.

Djukovic A; (...); Ubeda C

Article. 10.1128/AAC.01415-19. 2020

  • Open Access.

How to use biomarkers of infection or sepsis at the bedside: guide to clinicians.

Povoa, Pedro; (...); Kalil, Andre C.

Article. 10.1007/s00134-022-06956-y. 2023

  • Open Access.

Impact of amikacin pharmacokinetic/pharmacodynamic index on treatment response in critically ill patients

Ruiz, J; (...); Castellanos-Ortega, A

Article. 10.1016/j.jgar.2017.09.019. 2018


Impact of an antimicrobial stewardship program on critical haematological patients.

Ruiz-Ramos, J; (...); Ramirez, P

Article. 10.7399/fh.2017.41.4.10709. 2017

  • Open Access.

Impact of the "Zero Resistance" program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study.

Álvarez-Lerma F; (...); Martínez-Alonso M

Article. 10.1016/j.medine.2022.12.002. 2023


Impact of the ?Zero Resistance? program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study

Alvarez-Lerma, Francisco; (...); Martinez-Alonso, Montserrat

Article. 10.1016/j.medin.2022.12.002. 2023


Impact of voriconazole plasma concentrations on treatment response in critically ill patients

Ruiz, J; (...); Ramirez, P

Article. 10.1111/jcpt.12817. 2019


Implication of Haemodiafiltration Flow Rate on Amikacin Pharmacokinetic Parameters in Critically Ill Patients

Ruiz-Ramos, J; (...); Ramirez, P

Article. 10.1159/000478969. 2018


In vitro study of antimicrobial activity on Klebsiella Pneumoniae biofilms in endotracheal tubes

Ruiz, J; (...); Ramirez, P

Article. 10.1080/1120009X.2019.1601801. 2019


Incidence, risk factors, and outcome of pulmonary invasive fungal disease after respiratory virus infection in allogeneic hematopoietic stem cell transplantation recipients

Pinana, JL; (...); Navarro, D

Article. 10.1111/tid.13158. 2019

  • Open Access.

Individualised antimicrobial dosing in critically ill patients undergoing continuous renal replacement therapy: focus on total drug clearance

Ruiz, J; (...); Ramirez, P

Article. 10.1136/ejhpharm-2016-001114. 2018

  • Open Access.

Individualization of prophylaxis with recombinant factor VIII in severe or moderate hemophilia A

Vericat, JEM; (...); Bonanad, S

Meeting Abstract. 2018


Individualized Prophylactic Treatment with Recombinant Factor VIII in Severe or Moderate Haemophilia a Patients. Association Between Pharmacokinetic Parameters and Clinical Variables

Megias-Vericat, Juan Eduardo; (...); Bonanad, Santiago

Meeting Abstract. 10.1182/blood.V128.22.3802.3802. 2016


Infections of the Central Nervous System after Untelated Donor Umbilical Cord Blood Transplantation or Human teukocyte Antigen-Matched Sibling Transplantation

Balaguer Rosello A; (...); Sanz, J

Article. 10.1016/j.bbmt.2016.10.005. 2017

  • Open Access.

Influence of antibiotic pressure on multi-drug resistant Klebsiella pneumoniae colonisation in critically ill patients

Ruiz, J; (...); Ramirez, P

Article. 10.1186/s13756-019-0484-8. 2019

  • Open Access.

Influence of concomitant immunomodulators during maintenance therapy with Adalimumab in inflammatory bowel disease: looking for the ideal patient to use monotherapy

Bastida, G; (...); Nos, P

Meeting Abstract. 10.1093/ecco-jcc/jjy222.581. 2019

  • Open Access.

Influence of pharmacokinetic/pharmacodynamic ratio on vancomycin treatment response in paediatric patients with Staphylococcus aureus bacteremia.

Ruiz J; (...); Poveda JL

Article. 10.23736/S0026-4946.18.04978-2. 2018


Initial Antifungal Strategy Reduces Mortality in Critically Ill Patients With Candidemia: A Propensity Score-Adjusted Analysis of a Multicenter Study*

Garnacho-Montero, J; (...); Garcia-Garmendia, JL

Article. 10.1097/CCM.0000000000002867. 2018


Initial experience of use of tolvaptan in critically ill patients with fluid overload

Ruiz-Ramos J; (...); Ramirez P

Article. 10.1111/jcpt.12255. 2015


Intraperitoneal vancomycin in neonates during peritoneal dialysis: A case report

Company-Albir, MJ; (...); Poveda, JL

Article. 10.1111/jcpt.12842. 2019

  • Open Access.

Invasive aspergillosis in critically ill patients

Ramirez, P, Garnacho-Montero, J

Review. 10.1016/j.riam.2018.07.001. 2018


Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation.

Bueno F; (...); Navarro D

Article. 10.1111/tid.13507. 2020


Liquid nitrogen sterility in sperm, oocyte and embryo banking

Botella, IM; (...); Peman, J

Meeting Abstract. 2017


Live donor kidney transplantation. Situation analysis and roadmap.

de la Oliva Valentín M; (...); Domínguez-Gil B

Article. 10.1016/j.nefroe.2022.02.002. 2022

  • Open Access.

Lower Respiratory Tract Infection and Short-Term Outcome in Patients With Acute Respiratory Distress Syndrome.

Zampieri FG; (...); TAVeM study group

Article. 10.1177/0885066618772498. 2018

  • Open Access.

Lymphocyte Subpopulations in Community-Acquired Pneumonia: Role of Cell-Mediated Immunity

Mendez, R; (...); Menendez, R

Meeting Abstract. 2018


Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality

Mendez, R; (...); Torres, A

Article. 10.1016/j.jinf.2019.04.006. 2019


Management of flexible cavovarus foot in patients with Charcot-Marie-Tooth disease: midterm results.

Megías-Vericat JE; (...); Poveda-Andrés JL

Article. 2021

  • Open Access.

Management of infectious complications associated with coronavirus infection in severe patients admitted to ICU.

Estella, A; (...); Zaragoza, R

Article. 10.1016/j.medine.2021.08.013. 2021

  • Open Access.

MINIMALLY INVASIVE VERSUS OPEN HYSTERECTOMY IN HIGH-RISK ENDOMETRIAL CANCER: A PROPENSITY SCORE MATCHING ANALYSIS

Segarra Vidal, B.; (...); Ramirez, P.

Meeting Abstract. 10.1136/ijgc-2021-ESGO.206. 2021

  • Open Access.

Monitoring coagulation factors during surgery. A systematic review

Eduardo Megias-Vericat, Juan; (...); Luis Poveda-Andres, Jose

Review. 10.7399/fh.11766. 2021


Monographic: antisepsis in the critical patient Introduction

Ramirez, P., Nuvials, X., Diaz, E.

Editorial Material. 10.1016/j.medin.2018.07.018. 2019


New evidence in severe pneumonia: meropenem-vaborbactam.

Forteza Guillot, Maria, Martin Cerezuela, Maria, Ramirez, Paula

Article. 10.37201/req/s01.10.2022. 2022

  • Open Access.

Outbreak of Candida auris in Spain: A comparison of antifungal activity by three methods with published data

Ruiz-Gaitan, AC; (...); Peman, Javier

Article. 10.1016/j.ijantimicag.2019.02.005. 2019


OUTCOMES FOLLOWING OPEN RADICAL HYSTERECTOMY AFTER IMPLEMENTATION OF AN ENHANCED RECOVERY AFTER SURGERY (ERAS) PROGRAM

Agusti, N.; (...); Ramirez, P.

Meeting Abstract. 10.1136/ijgc-2021-ESGO.67. 2021

  • Open Access.

Pharmacist care in hospital emergency departments: a consensus paper from the Spanish hospital pharmacy and emergency medicine associations

Ramos, Jesus Ruiz; (...); Marco, Javier Povar

Article. 2023

  • Open Access.

Pharmacokinetics of Amikacin in Critical Care Patients on Extracorporeal Device

Ruiz-Ramos, J; (...); Castellanos-Ortega, A

Article. 10.1097/MAT.0000000000000689. 2018


Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants

Jacqz-Aigrain, E; (...); Zhao, W

Article. 10.1093/jac/dkz158. 2019

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Practical document on the management of hyponatremia in critically ill patients

Porcar, MJB; (...); Herrera-Gutierrez, ME

Article. 10.1016/j.medin.2018.12.002. 2019


Preoperative skin antisepsis

Galleymore, PR, Viera, V

Article. 10.1016/j.medin.2018.07.019. 2019


Proactive therapeutic drug monitoring and pharmacogenetic analysis in inflammatory bowel disease: A systematic review

Ballesta-Lopez, Octavio; (...); Luis Poveda-Andres, Jose

Review. 10.7399/fh.11780. 2021

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Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia

Pinana, JL; (...); Navarro, D

Article. 10.1016/j.jinf.2019.02.009. 2019

  • Open Access.

Pulmonary invasive fungal disease after community acquire respiratory virus infection in allogeneic hematopoietic stem cell transplantation recipients: Results from a prospective observational study

Pinana, Jose; (...); Navarro, David

Meeting Abstract. 2019


Recomendaciones GEMICOMED/GEIRAS-SEIMC para el manejo de las infecciones y colonizaciones por Candida auris.

Alastruey-Izquierdo A; (...); en nombre de GEMICOMED GEIRAS-SEIMC

Abstract of Published Item. 10.1016/j.riam.2019.06.001. 2019


Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units.

Vidal-Cortés P; (...); Zaragoza Crespo R

Practice Guideline. 10.1016/j.medine.2021.11.019. 2022

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Recommendations of the Working Groups from the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) for the management of adult critically ill patients

Hernandez-Tejedor, A; (...); Herrera-Gutierrez, ME

Article. 10.1016/j.medin.2017.03.004. 2017


Reply to: "ormothermic regional perfusion - What is the benefit?''

Hessheimer, AJ; (...); Fondevila, C

Letter. 10.1016/j.jhep.2019.04.005. 2019

  • Open Access.

Risk factors for mortality among patients with Pseudomonas aeruginosa bacteraemia: a retrospective multicentre study.

Babich T; (...); Yahav D

Article. 10.1016/j.ijantimicag.2019.11.004. 2020


Risk of immunomediated adverse events or secondary loss of response to infliximab in elderly patients with inflammatory bowel disease: a cohort study of the ENEIDA registry

Calafat, M; (...); Domenech, E

Meeting Abstract. 10.1093/ecco-jcc/jjy222.561. 2019


SEPTIC PARTICIPATION IN CARDIOGENIC SHOCK: EXPOSURE TO BACTERIAL ENDOTOXIN

Ramirez, P; (...); Vila, J

Article. 10.1097/SHK.0000000000000798. 2017


Serum Adalimumab Levels Predict Successful Remission and Safe Deintensification in Inflammatory Bowel Disease Patients in Clinical Practice

Aguas Peris M; (...); Nos, P

Article. 10.1097/MIB.0000000000001182. 2017

  • Open Access.

Serum adalimumab levels predict successful remission and safe de-intensification in inflammatory bowel disease patients in clinical practice

Aguas, M; (...); Nos, P

Meeting Abstract. 2017


Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit.

Martín-Cerezuela M; (...); Ramírez-Galleymore P

Article. 10.1186/s13054-023-04347-3. 2023

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Silver-embedded screens in the intensive care unit. A new tool to control multi-drug resistant bacterial cross-transmission

Ruiz J; (...); Castellanos Á

Article. 10.1007/s10096-017-2959-y. 2017


Soluble urokinase plasminogen activator receptor (suPAR) for the prediction of ventilator-associated pneumonia (VAP)

van Oort, PMP; (...); Martin-Loeches, I

Meeting Abstract. 10.1183/13993003.congress-2018.PA2607. 2018


Soluble urokinase plasminogen activator receptor for the prediction of ventilator-associated pneumonia.

van Oort PM; (...); Martin-Loeches I

Article. 10.1183/23120541.00212-2018. 2019

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Switching from immediate- to extended-release cysteamine in patients with nephropathic cystinosis: from clinical trials to clinical practice.

Ariceta G; (...); Vara J

Article. 10.1093/ckj/sfae049. 2024

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Ten Issues to Update in Nosocomial or Hospital-Acquired Pneumonia: An Expert Review.

Candel, Francisco Javier; (...); Zaragoza, Rafael

Article. 10.3390/jcm12206526. 2023

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Textbook outcome in patients with biliary duct injury during cholecystectomy.

Lopez-Lopez V; (...); Robles-Campos R

Article. 10.1016/j.gassur.2024.02.027. 2024


The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem cell transplantation.

Piñana J; (...); Sanz J

Article. 10.1016/j.jinf.2019.12.022. 2020

  • Open Access.

The challenge of multiresistant microorganisms.

Vicent C, Ramírez P

Editorial Material. 10.1016/j.medcli.2023.12.004. 2024

  • Open Access.

The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey.

Piñana JL; (...); Navarro D

Article. 10.1038/s41409-019-0698-7. 2020

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The UK DCD Risk Score: Still no consensus on futility in DCD liver transplantation

Hessheimer, AJ; (...); Fondevila, C

Letter. 10.1016/j.jhep.2019.01.004. 2019

  • Open Access.

Time-kill assays of amphotericin B plus anidulafungin against Candida tropicalis biofilms formed on two different biomaterials

Fernandez-Rivero, ME; (...); Canton, E

Article. 10.5301/ijao.5000652. 2018


Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule.

Marques MR; (...); Mangas-Sanjuan V

Article. 10.1111/apa.14944. 2020


Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial

Nunez-Ramiro, A; (...); Hypotop Study Grp

Article. 10.1159/000499084. 2019


Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia

Almansa, R; (...); Martin-Loeches, I

Article. 10.21037/atm.2018.05.12. 2018

  • Open Access.

Transcriptomics reveals shared immunosuppressive landscapes in ventilator-associated lower respiratory tract infections (VA-LRTI) patients.

Martin-Loeches I; (...); Bermejo-Martín JF

Article. 10.1080/14787210.2023.2256979. 2023

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Treatment of critically ill patients with cefiderocol for infections caused by multidrug-resistant pathogens: review of the evidence.

Viale, Pierluigi; (...); Lodise, Thomas P.

Article. 10.1186/s13613-023-01146-5. 2023

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Treatment of invasive fungal disease using anidulafungin alone or in combination for hematologic patients with concomitant hepatic or renal impairment

Montesinos P; (...); Sanz MÁ

Article. 10.1016/j.riam.2014.10.003. 2015


Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis.

Martin-Loeches I; (...); Artigas A

Article. 10.1186/s40635-015-0062-1. 2015


Undetectable levels of adalimumab in clinical practice: Should we say goodbye to the drug?

Bejar, S; (...); Mateu, PN

Meeting Abstract. 2020


Update of the treatment of nosocomial pneumonia in the ICU

Zaragoza, R; (...); Martin-Loeches, I

Review. 10.1186/s13054-020-03091-2. 2020

  • Open Access.

Update on invasive candidiasis in non-neutropenic critically ill adult patients

Zaragoza R; (...); Pemán J

Review. 10.1016/j.riam.2016.03.001. 2016


Usefulness of procalcitonin for diagnosing infection in critically ill patients with liver cirrhosis

Villarreal E; (...); Ramírez P

Article. 10.1016/j.medin.2015.02.006. 2016


Vancomycin and daptomycin minimum inhibitory concentrations as a predictor of outcome of methicillin-resistant Staphylococcus aureus bacteraemia

Ruiz, J; (...); Castellanos-Ortega, A

Article. 10.1016/j.jgar.2018.03.007. 2018


Vasopressin antagonist efficacy and safety in volume-overloaded critically ill patients: a new therapeutic alternative

Ruiz-Ramos, J; (...); Castellanos-Ortega, A

Article. 10.1136/ejhpharm-2018-001664. 2020

  • Open Access.

Ventilator-associated pneumonia by methicillin-susceptible Staphylococcus aureus: do minimum inhibitory concentrations to vancomycin and daptomycin matter?

Ruiz-Ramos, J; (...); Ramirez, P

Article. 10.1007/s10096-017-2970-3. 2017


Análisis Epidemiológico, Clínico Y Microbiológico Del Brote De Candidiasis Invasora Por Candida Auris En El Hospital Universitario Y Politécnico La Fe

Autor/es: Alba Cecilia Ruiz Gaitán

Tesis Doctoral

Director/es: JAVIER PEMÁN GARCÍA; PAULA RAMÍREZ GALLEYMORE


Fisiopatogenia Y Diagnóstico De La Ventriculitis Asociada A Drenaje Ventricular Externo

Autor/es: Mónica Gordón Sahuquillo

Tesis Doctoral

Director/es: PAULA RAMÍREZ GALLEYMORE; PAULA RAMÍREZ GALLEYMORE; Soriano A


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