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ESTUDIO EN FASE 2, ABIERTO Y DE UN SOLO GRUPO DE IRINOTECAN EN COMBINACION CON TEMOZOLOMIDA EN NIÑOS CON MEDULOBLASTOMA RECURRENTE O REFRACTARIO Y EN NIÑOS CON GLIOMA DE ALTO GRADO RECIEN DIAGNOSTICADO.
Dades bàsiques
- Protocol:
- A5961166
- EURDRACT:
- 2006-005476-40
- NCT:
- Centre:
- Any inici:
- Any de finalització:
Documents
- No hi ha documents
Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
A NATIONAL PEDIATRIC NEURO-ONCOLOGY TUMOR BOARD INITIATIVE IN SPAIN: RESULTS OF A WEB-BASED SURVEY TO EVALUATE PARTICIPANT EXPERIENCE UTILIZING THIS RESOURCE
Illade, Laura; (...); Lassaletta, Alvaro
Article. 2022
A Randomized Comparison of Liposomal Daunorubicin/Daunorubicin Combined with Low-Dose Cytarabine and Etoposide or High-Dose Cytarabine and Fludarabine in Induction Treatment of Pediatric AML Using MRD- Based Risk Stratification in the NOPHO-DBH AML 2012 Protocol
De Moerloose, Barbara; (...); Abrahamsson, Jonas
Meeting Abstract. 10.1182/blood-2023-187251. 2023
Alectinib in pediatric patients with solid or CNS tumors harboring ALK-fusions: Emerging pharmacokinetic data from the iMATRIX alectinib phase I/II open-label, multi-center study
Doz, Francois; (...); Gajjar, Amar J.
Meeting Abstract. https://doi.org/10.1200/JCO.2024.42.16_suppl.3098. 2024
ASSESSMENT OF A NOVEL READY-TO-USE TEMOZOLOMIDE ORAL SUSPENSION IN CHILDREN WITH SOLID TUMORS: RESULTS OF TEMOKIDS, A POPULATION PHARMACOKINETIC, ACCEPTABILITY AND SAFETY PHASE-1 STUDY
Abbou, Samuel; (...); Metayer, Lucy
Meeting Abstract. 2023
Atypical B-Cell Acute Lymphoblastic Leukemia with iAMP21 in the Context of Constitutional Ring Chromosome 21: A Case Report and Review of the Genetic Insights.
Gil, Jose Vicente; (...); Llop, Marta
Article. 10.3390/ijms26010357. 2025
Barriers and facilitators to the implementation of a new European eHealth solution (SurPass v2.0): the PanCareSurPass Open Space study.
de Beijer IAE; (...); Pluijm SMF
Article. 10.1007/s11764-023-01498-8. 2023
Cadmium (Cd) and Lead (Pb) topsoil levels and incidence of childhood leukemias
Asenjo S; (...); Ramis R
Article. 10.1007/s10653-021-01030-w. 2021
Cancer is not a risk factor for severe COVID-19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantation or comorbidities.
Velasco Puyó P; (...); Astigarraga I
Article. 10.1002/pbc.31120. 2024
Casuística de tumor miofibroblástico inflamatorio en centro terciario.
Martínez Navarro G; (...); Fernández Navarro JM
Case Reports. 10.1016/j.anpedi.2020.12.007. 2021
Casuistics of inflammatory myofibroblastic tumor in a tertiary center.
Martínez Navarro G; (...); Fernández Navarro JM
Case Reports. 10.1016/j.anpede.2020.12.016. 2021
Comparative Multicentric Evaluation of Inter-Observer Variability in Manual and Automatic Segmentation of Neuroblastic Tumors in Magnetic Resonance Images
Veiga-Canuto, Diana; (...); Marti-Bonmati, Luis
Article. 10.3390/cancers14153648. 2022
Comprehensive detection of CRLF2 alterations in acute lymphoblastic leukemia: a rapid and accurate novel approach.
Gil, Jose Vicente; (...); Barragan, Eva
Article. 10.3389/fmolb.2024.1362081. 2024
Current status of precision medicine in pediatric oncology in Spain: a consensus report by the Spanish Society of Paediatric Haematology and Oncology (SEHOP).
Gargallo, P.; (...); Moreno, L.
Article. 10.1007/s12094-021-02759-7. 2022
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13)
Ostlund, Anders; (...); Palmqvist, Lars
Article. 10.1002/gcc.70003. 2024
Childhood and Adolescent Central Nervous System Tumours in Spain: Incidence and Survival over 20 Years: A Historical Baseline for Current Assessment.
Chirlaque MD; (...); The Spanish Childhood Cancer Epidemiology Working Group
Article. 10.3390/cancers15245889. 2023
Chip-AML22 Master Protocol: An Open-Label Clinical Trial in Newly Diagnosed Pediatric De Novo Acute Myeloid Leukemia (AML) Patients Including a Linked Phase II Trial with Quizartinib in FLT3-ITD/ NPM1wt Patients - a Study By the NOPHO-DB-SHIP Consortium
Kaspers, Gertjan J. L.; (...); Pronk, Cornelis Jan
Meeting Abstract. 10.1182/blood-2023-181792. 2023
Delving into the clinical impact of NETs in pediatric cancer.
Benavent N; (...); Medina P
Article. 10.1038/s41390-024-03437-4. 2024
ECLIM-SEHOP: how to develop a platform to conduct academic trials for childhood cancer.
Juan-Ribelles A; (...); Fernández-Teijeiro A
Article. 10.1007/s12094-024-03445-0. 2024
Evaluation of circulating tumor DNA by electropherogram analysis and methylome profiling in high-risk neuroblastomas
Trinidad, Eva Maria; (...); de Mora, Jaime Font
Article. 10.3389/fonc.2023.1037342. 2023
Experience of the Spanish Group for Hematopoietic Transplantation (GETMON-GETH) in allogenic Hematopoietic stem cell Transplantation in Philadelphia acute lymphoblastic leukemia.
Galán Gómez V; (...); Pérez-Martínez A
Article. 10.1016/j.anpede.2021.02.016. 2022
Fertility preservation in children/adolescent patient with cancer
Moreno, M. Andres, Sanchez, H. Martinez, Macian, F. Moreno
Article. 10.1016/j.gine.2024.100966. 2024
Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1).
Bellini, Angela; (...); Schleiermacher, Gudrun
Article. 10.1200/JCO.21.00086. 2021
Germline Predisposition to Pediatric Cancer, from Next Generation Sequencing to Medical Care.
Gargallo P; (...); Cañete A
Article. 10.3390/cancers13215339. 2021
Germline variant in Ctcf links mental retardation to Wilms tumor predisposition
Gargallo, Pablo; (...); Font de Mora, Jaime
Article. 10.1038/s41431-022-01105-x. 2022
Haploidentical versus Cord Blood transplantation in pediatric AML. A retrospective outcome analysis on behalf of the pediatric subcommittee of GETH (Grupo Español de Trasplante Hematopoyético).
Sisinni L; (...); de Heredia CD
Article. 10.1016/j.jtct.2024.07.013. 2024
Haploidentical vs. HLA-matched donor hematopoietic stem-cell transplantation for pediatric patients with acute lymphoblastic leukemia in second remission: A collaborative retrospective study of the Spanish Group for Bone Marrow Transplantation in Children (GETMON/GETH) and the Spanish Childhood Relapsed ALL Board (ReALLNet).
Moreno, Celia; (...); Fuster, Jose Luis
Article. 10.3389/fped.2023.1140637. 2023
Hematopoietic stem cell transplantation in children with chronic granulomatous disease: the Spanish experience.
Alonso García L; (...); Diaz de Heredia Rubio C
Article. 10.3389/fimmu.2024.1307932. 2024
HIGH RISK NEUROBLASTOMA (HR-NB) WITH MNA AND AGE
Ladenstein, Ruth; (...); Canete, Adela
Meeting Abstract. 2023
High risk neuroblastoma (HR-NB) with MNA and age <18 months: Results from the HR-NBL1/SIOPEN trial
Ladenstein, Ruth Lydia; (...); Canete, Adela
Meeting Abstract. 2023
Independent Validation of a Deep Learning nnU-Net Tool for Neuroblastoma Detection and Segmentation in MR Images
Veiga-Canuto, Diana; (...); Marti-Bonmati, Luis
Article. 10.3390/cancers15051622. 2023
International benchmarking of childhood cancer survival by tumour stage: First results of the BENCHISTA project
Pritchard-Jones, K.; (...); Gatta, G.
Meeting Abstract. 2024
International benchmarking of stage at diagnosis for six childhood solid tumours (the BENCHISTA project): a population-based, retrospective cohort study.
Botta, Laura; (...); Pritchard-Jones, Kathy
Article. 10.1016/S2352-4642(24)00302-X. 2025
IT-Related Barriers and Facilitators to the Implementation of a New European eHealth Solution, the Digital Survivorship Passport (SurPass Version 2.0): Semistructured Digital Survey.
de Beijer, Ismay A E; (...); Chronaki, Catherine
Article. 10.2196/49910. 2024
Langerhans cell histiocytosis of the head and neck in the pediatric population in a tertiary center: Clinical presentation, classification and treatment.
García Díaz MP; (...); Carceller, Miguel Armengot
Article. 10.1016/j.ijporl.2022.111073. 2022
Lateral-type posterior fossa ependymomas in pediatric population
Miranda-Lloret, Pablo; (...); Llavador, Gemma
Article. 10.1016/j.neucir.2023.10.002. 2024
Lateral-type posterior fossa ependymomas in pediatric population.
Miranda-Lloret, Pablo; (...); Llavador, Gemma
Article. 10.1016/j.neucie.2023.10.001. 2024
Lenvatinib with etoposide plus ifosfamide in patients with refractory or relapsed osteosarcoma (ITCC-050) : a multicentre, open-label, multicohort, phase 1/2 study
Gaspar, N; (...); Campbell-Hewson, Q
Article. 10.1016/S1470-2045(21)00387-9. 2021
Liquidhope: methylome and genomic profiling from very limited quantities of plasma-derived DNA.
Trinidad EM; (...); Font de Mora J
Article. 10.1093/bib/bbac575. 2023
Management of Hyperleukocytosis in Pediatric Acute Myeloid Leukemia Using Immediate Chemotherapy without Leukapheresis, in Protocol NOPHO-DBH AML-2012
Zeller, Bernward; (...); Abrahamsson, Jonas
Meeting Abstract. 10.1182/blood-2023-184921. 2023
Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 Protocol.
Zeller B; (...); Abrahamsson J
Article. 10.3324/haematol.2024.285285. 2024
Management of paediatric monomorphic post-transplant lymphoproliferative disorders with low-intensity treatment: A multicentre international experience.
Guerra-García P; (...); Taj MM
Article. 10.1002/pbc.31053. 2024
Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia: A Study by the International Berlin-Frankfurt-Münster Study Group.
van Weelderen, Romy E; (...); Kaspers GJL
Article. 10.1200/JCO.22.02120. 2023
Methodological advances in the discovery of novel neuroblastoma therapeutics.
Segura MF; (...); Moreno L
Article. 10.1080/17460441.2022.2002297. 2022
Mitoxantrone Versus Liposomal Daunorubicin in Induction of Pediatric AML With Risk Stratification Based on Flow Cytometry Measurement of Residual Disease.
Tierens, Anne; (...); Abrahamsson, Jonas
Article. 10.1200/JCO.23.01841. 2024
Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs.
Reinal, Ignacio; (...); Sepulveda, Pilar
Article. 10.3390/antiox12071378. 2023
MR Denoising Increases Radiomic Biomarker Precision and Reproducibility in Oncologic Imaging
Fernández Patón M; (...); Martí-Bonmatí L
Article. 10.1007/s10278-021-00512-8. 2021
MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial.
Rodriguez D; (...); Jaspan T
Article. 10.1148/radiol.211464. 2022
Neuroblastoma in Spain: Linking the national clinical database and epidemiological registries - A study by the Joint Action on Rare Cancers.
Cañete A; (...); Spanish Neuroblastoma Linkage Working Group (SpNbLinkWG)
Article. 10.1016/j.canep.2022.102145. 2022
Optimized Cytogenetic Risk-Group Stratification of KMT2A-Rearranged Pediatric Acute Myeloid Leukemia.
van Weelderen, Romy E.; (...); Kaspers, Gertjan J. L.
Article. 10.1182/bloodadvances.2023011771. 2024
Personalized Medicine in Infant Population with Cancer: Pharmacogenetic Pilot Study of Polymorphisms Related to Toxicity and Response to Chemotherapy.
Urtasun, Andrea; (...); Herrero, Maria Jose
Article. 10.3390/cancers15051424. 2023
Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next?
Olivera, GG; (...); Herrero, MJ
Review. 10.3390/ijms22189815. 2021
Phase I/II study of single-agent lenvatinib in children and adolescents with refractory or relapsed solid malignancies and young adults with osteosarcoma (ITCC-050) ? .
Gaspar N; (...); Casanova M
Article. 10.1016/j.esmoop.2021.100250. 2021
Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials.
Kelly, Sarah M.; (...); Mandeville, Henry
Article. 10.1016/j.radonc.2023.109549. 2023
Regorafenib Plus Vincristine and Irinotecan in Pediatric Patients With Recurrent/Refractory Solid Tumors: An Innovative Therapies for Children With Cancer Study.
Casanova M; (...); Geoerger B
Article. 10.1158/1078-0432.CCR-23-0257. 2023
Reproducibility Analysis of Radiomic Features on T2-weighted MR Images after Processing and Segmentation Alterations in Neuroblastoma Tumors.
Veiga-Canuto, Diana; (...); Marti-Bonmati, Luis
Article. 10.1148/ryai.230208. 2024
Retinoblastoma and mosaic 13q deletion: a case report
Gargallo P; (...); Canete, A
Article. 10.1186/s40942-021-00321-9. 2021
Staging childhood cancers in Europe: Application of the Toronto stage principles for neuroblastoma and Wilms tumour. The JARC pilot study.
Gatta G; (...); JARC Pilot Study Toronto Guidelines Working Group
Article. 10.1002/pbc.29020. 2021
Suprarenal Masses in Very Young Infants: Is It Safe to Watch and Wait? Report of a SIOPEN Observational Study Results
Papadakis, Vassilios; (...); Canete, Adela
Article. 10.3390/cancers14164007. 2022
Survival and Health Care Burden of Children With Retinoblastoma in Europe.
Virgili G; (...); Gatta G
Article. 10.1001/jamaophthalmol.2024.4140. 2024
THE BENCHISTA PROJECT: INTERNATIONAL BENCHMARKING OF CHILDHOOD CANCER SURVIVAL BY TUMOUR STAGE
Cortes, Angela Lopez; (...); Pritchard-Jones, Kathy
Article. 2022
Treosulfan-Based Conditioning Regimen In Pediatric Hematopoietic Stem Cell Transplantation: A Retrospective Analysis on Behalf of the Spanish Group for Hematopoietic Transplantation and Cellular Therapy (GETH-TC).
Galán V; (...); Pérez-Martínez A
Article. 10.1016/j.jtct.2023.08.016. 2023
Unraveling the extracellular matrix-tumor cell interactions to aid better targeted therapies for neuroblastoma
Burgos-Panadero, R; (...); Noguera, R
Article. 10.1016/j.ijpharm.2021.121058. 2021
Use of Eculizumab in Pediatric Patients with High-Risk Transplantation-Associated Thrombotic Microangiopathy: Outcomes and Risk Factors Associated with Response and Survival. A Retrospective Study on Behalf of the Spanish Group for Hematopoietic Transplantation and Cellular Therapy (GETH-TC).
Benítez Carabante MI; (...); Diaz-de-Heredia C
Article. 10.1016/j.jtct.2024.03.019. 2024
Vitronectin Levels in the Plasma of Neuroblastoma Patients and Culture Media of 3D Models: A Prognostic Circulating Biomarker?
Lopez-Carrasco, Amparo; (...); Noguera, Rosa
Article. 10.3390/ijms25168733. 2024