Estudio de los mecanismos moleculares de compactación y polarización en el embrión humano: implicaciones en la viabilidad embrionaria

Dades bàsiques

Protocol:
PI20/00523
EURDRACT:
NCT:
Centre:
Any inici:
2021
Any de finalització:
2024
PI BIOMÉDICA NACIONAL Finan. Competitiva Pública 49.610,00 €

Documents

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Participants

Grups d'Investigació

Finançadors - Promotors

INSTITUTO DE SALUD CARLOS III

Resultats de l'Assaig Clínic


A NEW ENDOMETRIAL TRANSCRIPTOMIC STRATIFICATION IN THE MID-SECRETORY PHASE REVEALS A NEW TAXONOMY FOR ENDOMETRIAL PROGNOSIS IN INFERTILITY

Maria Sanchez-Reyes, Josefa; (...); Diaz Gimeno, Patricia

Meeting Abstract. 2022


Analysis of serum and endometrial progesterone in determining endometrial receptivity.

Labarta E; (...); Diaz-Gimeno P

Article. 10.1093/humrep/deab184. 2021


Aneuploidy in Human Embryos May Elicit a Premature Differentiation Response in the Inner Cell Mass.

Martin, A; (...); de los Santos, MJ

Meeting Abstract. 2021


Association of blood cadmium and lead levels with self-reported reproductive lifespan and pregnancy loss: The national health and nutrition examination survey 1999-2018

Gonzalez-Martin, Roberto; (...); Dominguez, Francisco

Article. 10.1016/j.envres.2023.116514. 2023


Associations between Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single Embryo Transfer Cycles

Gonzalez-Martin, Roberto; (...); Dominguez, Francisco

Meeting Abstract. 2024


Embryo long-term storage does not affect assisted reproductive technologies outcome: analysis of 58,001 vitrified blastocysts over 11 years.

Cobo A; (...); Bellver J

Article. 10.1016/j.ajog.2024.03.033. 2024


Endometrial cortisol and estradiol levels as indicators of pregnancy prognosis and their association with State-Trait Anxiety Inventory (STAI) psychological questionnaire punctuations in IVF patients

Marti-Garcia, D.; (...); Diaz-Gimeno, P.

Meeting Abstract. 2023


Evaluation of salivary ELISA for Oestradiol and Progesterone monitoring in IVF patients

Bosch Aparicio, E.; (...); White, R.

Meeting Abstract. 2023


Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer.

Gonzalez-Martin, Roberto; (...); Dominguez, Francisco

Article. 10.3390/cells13100839. 2024

  • Open Access.

Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation.

Segura-Benítez M; (...); Ferrero H

Article. 10.1093/humrep/dead138. 2023

  • Open Access.

Human embryos diagnosed as mosaic and aneuploid after preimplantation genetic testing for aneuploidy are associated with increased levels of apoptosis in trophectoderm cells

Martin, A.; (...); De los Santos, M. J.

Meeting Abstract. 2023


Identifying and optimizing human endometrial gene expression signatures for endometrial dating.

Diaz-Gimeno P; (...); Pellicer A

Article. 10.1093/humrep/deab262. 2022


Impact of low serum progesterone levels on the day of embryo transfer on pregnancy outcome: a prospective cohort study in artificial cycles with vaginal progesterone.

Labarta E; (...); Bosch E

Article. 10.1093/humrep/deaa322. 2021


Impaired endometrial decidualization with a hyperinflammation environment is involved in poor reproductive outcomes in adenomyosis patients

Corachan, A.; (...); Ferrero, H.

Meeting Abstract. 2023


Intentional endometrial injury significantly improves ongoing pregnancy rates of an oocyte donation program in patients without recurrent implantation failure (RIF): a randomized controlled trial.

Vidal, C.; (...); Garrido, N.

Meeting Abstract. 2023


Medroxyprogesterone acetate is a useful alternative to a gonadotropin-releasing hormone antagonist in oocyte donation: a randomized, controlled trial.

Giles J; (...); Bosch E

Article. 10.1016/j.fertnstert.2021.02.036. 2021


Medroxyprogesterone acetate: an alternative to GnRH-antagonist in oocyte vitrification for social fertility preservation and preimplantation genetic testing for aneuploidy.

Giles, Juan; (...); Bosch, Ernesto

Article. 10.1016/j.rbmo.2023.04.013. 2023

  • Open Access.

Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.

Martin, A.; (...); de los Santos, M. J.

Article. 10.3389/fmolb.2023.1180689. 2023

  • Open Access.

Nervous system drugs are predicted as potential repurposing candidates for treatment in endometrial failure

Parraga-Leo, A.; (...); Diaz-Gimeno, P.

Meeting Abstract. 2023


Non-Essential Trace Elements in women's biofluids are associated with worse IVF outcomes in euploid single embryo transfer cycles

Gonzalez-Martin, R.; (...); Dominguez, F.

Meeting Abstract. 2023


Oocyte Maturity, Embryology Outcomes and miRNA Signature of Different Size Follicles from Poor Responder Patients.

Yague-Serrano, Roberto; (...); Dominguez, Francisco

Meeting Abstract. 2024


Predicting risk of endometrial failure: a biomarker signature that identifies a novel disruption independent of endometrial timing in patients undergoing hormonal replacement cycles.

Diaz-Gimeno P; (...); Pellicer A

Article. 10.1016/j.fertnstert.2024.03.015. 2024


Role of Endometrial Extracellular Vesicles miRNAs as Potential Autocrine Regulators of Gene Expression During Embryo Implantation Process in Adenomyosis.

Juarez-Barber, Elena; (...); Ferrero, Hortensia

Meeting Abstract. 2024


Secretion of beta-human chorionic gonadotropin (b-hCG) by post-implantation embryos differs according to different chromosomal status.

Palomar, A.; (...); Sanchez-Ribas, I.

Meeting Abstract. 2023


SERUM P LEVELS MEASURED ON THE DAY OF EMBRYO TRANSFER IN FRESH IVF CYCLES yam OWN OOCYTES ARE NOT RELATED TO PREGNANCY OUTCOME.

Labarta, Elena; (...); Bosch, Ernesto

Meeting Abstract. 2022


The effect of vitrification on blastocyst mitochondrial DNA dynamics and gene expression profiles.

Perez-Sanchez, Marta; (...); de Los Santos, Maria Jose

Article. 10.1007/s10815-023-02952-3. 2023


The morphokinetic signature of mosaic embryos: evidence in support of their own genetic identity.

Martín Á; (...); José de Los Santos M

Article. 10.1016/j.fertnstert.2020.12.031. 2021

  • Open Access.

Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.

Juarez-Barber, Elena; (...); Ferrero, Hortensia

Article. 10.1186/s12958-023-01182-7. 2024

  • Open Access.

Transcriptomic Analysis of Adenomyosis Mid-Secretory Endometrial Organoids Reveals Deregulated Molecular Mechanisms Involved in Implantation Failure and Pregnancy Loss

Juarez-Barber, Elena; (...); Ferrero, Hortensia

Meeting Abstract. 2023


Transcriptomic analysis reveals deregulated molecular mechanisms related to miscarriage, preeclampsia, and pregnancy complications during gestational endometrial phase in adenomyosis

Juarez-Barber, E.; (...); Ferrero, H.

Meeting Abstract. 2023


Trophectoderm cells of human mosaic embryos display increased apoptotic levels and impaired differentiation capacity: a molecular clue regarding their reproductive fate?

Martin, Angel; (...); de Los Santos, Maria Jose

Article. 10.1093/humrep/deae009. 2024


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