Portal de investigación
RETROSPECTIVE OBSERVATIONAL STUDY OF PATIENTS WITH METASTATIC, UNRESECTABLE OR LOCALLY ADVANCED GASTROINTESTINAL STROMAL TUMOURS (GIST) TREATED WITH SUNITINIB. EXPLORATORY ANALYSIS OF PROGNOSTIC AND PREDICTIVE FACTORS IN LONG-TERM RESPONDER PATIENTS.
Datos básicos
- Protocolo:
- GEI-SUN-2016-01
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2017
- Año de finalización:
- 2019
Objetivos del proyecto
Observaciones: Estado Comité: ACTIVO
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study.
Martínez-Trufero J; (...); Gutiérrez A
Article. 10.3390/cancers13040792. 2021
A multicenter phase 2 study of nivolumab combined with ipilimumab in patients with pediatric solid tumors in adulthood (GETHI021).
Mielgo, Xabier; (...); Garcia-Donas, Jesus
Meeting Abstract. 10.1200/JCO.2018.36.15_suppl.TPS3123. 2018
An internally validated new clinical and inflammation-based prognostic score for patients with advanced hepatocellular carcinoma treated with sorafenib
Diaz-Beveridge, R; (...); Aparicio, J
Article. 10.1007/s12094-017-1720-4. 2018
Baseline circulating myeloid-derived suppressor cells subpopulations, neutrophils/lymphocytes ratio, and response to PD-1/PD-L1 inhibitor in non-small cell lung cancer patients.
SAnchez, JosE GarcIa; (...); Lahoz, Agustin
Meeting Abstract. 2020
CINSARC in high-risk soft tissue sarcoma patients treated with neoadjuvant chemotherapy: Results from the ISG-STS 1001 study
Frezza, Anna Maria; (...); Gronchi, Alessandro
Article. 10.1002/cam4.5015. 2022
Clinical Characteristics and Management of Patients with Secondary Hyperparathyroidism Undergoing Hemodialysis: A Feasibility Analysis of Electronic Health Records Using Natural Language Processing.
Ortiz A; (...); Rodriguez M
Article. 10.1159/000528784. 2023
Clinicopathologic features and long-term follow-up of metastatic gastrointestinal stromal tumor (GIST) patients (pts) with durable response (> 5 years) to frontline imatinib (IM): A case-control study from GEIS
Serrano, C; (...); Broto, JM
Meeting Abstract. 2017
Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib
Serrano, C; (...); Carles, J
Article. 10.1634/theoncologist.2018-0032. 2019
Characteristics and outcomes of advanced melanoma patients with complete response and elective discontinuation of first-line anti-programmed death-1 monotherapy: A real-world multicentre observational cohort study.
Ochenduszko, Sebastian; (...); Maiques, Inmaculada Maestu
Article. 10.1111/pcmr.13093. 2023
Early radiological response as predictor of overall survival in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor mutations
Salvador-Coloma, C; (...); Juan, O
Article. 10.21037/jtd.2018.02.30. 2018
Encorafenib (E) plus binimetinib (B) in unresectable advanced or metastatic BRAFV600-mut melanoma, real-world evidence in Spain (GEM 2002-BECARE)
Soria, A.; (...); Cerezuela-Fuentes, P.
Meeting Abstract. 10.1016/j.annonc.2023.09.2248. 2023
Encorafenib and binimetinib followed by radiotherapy for patients with BRAFV600-mutant melanoma and brain metastases (E-BRAIN/GEM1802 phase II study).
Marquez-Rodas, Ivan; (...); Berrocal, Alfonso
Article. 10.1093/neuonc/noae116. 2024
First in human trial of CEB-01 for retroperitoneal soft tissue sarcoma
Gonzalez, J. A.; (...); Lopez Pousa, A.
Meeting Abstract. 10.1016/j.annonc.2023.09.1161. 2023
First-in-human CEB-01: Novel loco-regional SN-38 release membrane to prevent local recurrence in retroperitoneal sarcomas
Gonzalez-Lopez, Jose Antonio; (...); Pousa, Antonio Lopez
Meeting Abstract. https://doi.org/10.1016/j.annonc.2023.09.1161. 2024
Gemcitabine plus sirolimus for relapsed and progressing osteosarcoma patients after standard chemotherapy: a multicenter, single-arm phase II trial of Spanish Group for Research on Sarcoma (GEIS)
Martin-Broto, J; (...); Lopez-Pousa, A
Article. 10.1093/annonc/mdx536. 2017
Identification Of Actionable Genetic Targets In Primary Cardiac Sarcomas
Salvador-Coloma, C; (...); de Mora, JF
Article. 10.2147/OTT.S214319. 2019
Immune-related adverse events (irAEs) and survival (OS) in metastatic non-small cell lung cancer (mNSCLC) patients (pts) treated with immunotherapy
Melian Sosa, M.; (...); Lorente, D.
Meeting Abstract. 2018
ImmunoSarc2: A Spanish Sarcoma Group (GEIS) phase Ib trial of doxorubicin and dacarbazine plus nivolumab in first line treatment of advanced leiomyosarcoma
Martin Broto, Javier; (...); Hindi, Nadia
Meeting Abstract. 2023
Interim analysis of a phase II study of nivolumab combined with ipilimumab in patients with pediatric solid tumors in adulthood (GETHI021).
Mielgo, X; (...); Garcia-Donas, J
Meeting Abstract. 10.1200/JCO.2019.37.15_suppl.2613. 2019
Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial.
Gonzalez-Cao M; (...); Berrocal A
Article. 10.1038/s41467-021-26572-6. 2021
Intracranial activity of encorafenib and binimetinib followed by radiotherapy in patients with BRAF mutated melanoma and brain metastasis: Preliminary results of the GEM1802/EBRAIN-MEL phase II clinical trial
Marquez-Rodas, I; (...); Berrocal, A
Meeting Abstract. 10.1016/j.annonc.2021.08.1423. 2021
Long-Term Survival for Brain-Only Oligometastatic NSCLC Patients Treated with Ablative Therapy (AT): Prognostic Factors
Salvador Coloma, C.; (...); Juan-Vidal, O.
Meeting Abstract. 2018
Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
Melian, M; (...); Juan, O
Article. 10.1111/1759-7714.12873. 2018
Management and supportive treatment of frail patients with metastatic pancreatic cancer
Macarulla, T; (...); Hidalgo, M
Review. 10.1016/j.jgo.2018.06.005. 2019
Multicenter real-world data of treatment with NALIRI plus 5FU/LV in advanced Spanish pancreatic cancer
Alvarez Gallego, R.; (...); Cubillo, A.
Meeting Abstract. 10.1016/j.annonc.2023.04.238. 2023
Neoadjuvant Chemotherapy in High-Grade Myxoid Liposarcoma: Results of the Expanded Cohort of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish Sarcoma Groups (PSG).
Gronchi, Alessandro; (...); Casali, Paolo Giovanni
Article. 10.1200/JCO.23.00908. 2024
Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk stratification analysis of the ISG-STS 1001 randomized trial.
Pasquali, Sandro; (...); Gronchi, Alessandro
Article. 10.1002/cncr.33895. 2022
Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups
Gronchi, A; (...); Casali, PG
Article. 10.1200/JCO.19.03289. 2020
Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: Results of the expanded cohort of myxoid liposarcoma of the randomized clinical trial from the Italian Sarcoma Group (ISG), the Spanish Sarcoma Group (GEIS), the French Sarcoma Group (FSG), and the Polish Sarcoma Group (PSG).
Gronchi, Alessandro; (...); Casali, Paolo Giovanni
Meeting Abstract. 2022
Neoadjuvant treatment for borderline and resectable pancreatic ductal adenocarcinoma
Alvarez, R; (...); Hidalgo, M
Review. 10.1007/s12094-017-1680-8. 2017
Outcomes after neoadjuvant treatment with gemcitabine and erlotinib followed by gemcitabine-erlotinib and radiotherapy for resectable pancreatic cancer (GEMCAD 10-03 trial)
Maurel, J; (...); Fernandez-Cruz, L
Article. 10.1007/s00280-018-3682-9. 2018
Pancreatic cancer, Radiomics and Artificial Intelligence: A Review.
Marti-Bonmati L; (...); Alberich-Bayarri A
Article. 10.1259/bjr.20220072. 2022
Pharmacogenetics of Neoadjuvant MAP Chemotherapy in Localized Osteosarcoma: A Study Based on Data from the GEIS-33 Protocol
Salazar, Juliana; (...); Sebio, Ana
Article. 10.3390/pharmaceutics16121585. 2024
Phase I/II Trial to Evaluate the Efficacy and Safety of Nanoparticle Albumin-Bound Paclitaxel in Combination With Gemcitabine in Patients With Pancreatic Cancer and an ECOG Performance Status of 2
Macarulla, T; (...); Hidalgo, M
Article. 10.1200/JCO.18.00089. 2019
Phase Ib Study for the Combination of Doxorubicin, Dacarbazine, and Nivolumab as the Upfront Treatment in Patients With Advanced Leiomyosarcoma: A Study by the Spanish Sarcoma Group (GEIS).
Martin-Broto J; (...); Hindi N
Article. 10.1200/JCO.24.00358. 2024
Phase II trial of palbociclib in advanced sarcoma overexpressing CDK4 gene excluding dedifferentiated liposarcoma (DD LPS): A study from the Spanish Group for Research on Sarcoma (GEIS).
Broto, Javier Martin; (...); Hindi, Nadia
Meeting Abstract. 2022
Preliminarily results of the Oncohabitats Study: A multicentre validation of overall survival (OS) estimation of patients with glioblastoma (GBM) using vascular biomarkers
Alvarez-Torres, MD; (...); Garcia-Gomez, JM
Meeting Abstract. 10.1158/1538-7445.AM2019-4258. 2019
Pretreatment T790M mutation detection by ultrasensitive PCR assay as predictor of efficacy in non-small lung cancer (NSCLC) patients treated with 1st or 2nd generation EGFR tyrosine kinase inhibitors (TKIs)
Vidal, OJJ; (...); Palanca, S
Meeting Abstract. 2019
Prognostic factors in oligometastatic non-small-cell lung cancer (OM-NSCLC)
Juan, O; (...); Codina, JG
Meeting Abstract. 10.1016/S1556-0864(18)30411-8. 2018
Prognostic factors in oligometastatic non-small-cell lung cancer (OM-NSCLC) patients treated with ablative therapy.
Antonio Mendez, Juan; (...); Juan Vidal, Oscar
Meeting Abstract. 10.1200/JCO.2018.36.15_suppl.e21089. 2018
Prognostic role of HMG proteins in a series of 301 advanced soft tissue sarcoma patients: A Spanish Group for Sarcoma Research Study (GEIS).
Hindi, N; (...); Broto, JM
Meeting Abstract. 10.1200/JCO.2018.36.15_suppl.11573. 2018
Real-world effectiveness and safety of second- or third-line pegylated liposomal irinotecan plus 5-fluorouracil and folinic acid in pancreatic ductal adenocarcinoma in Spain
Alvarez-Gallego, Rafael; (...); Cubillo, Antonio
Article. 10.1177/17588359241309828. 2025
Real-world study on characteristics of advanced melanoma patients with sustained complete response (CR) after elective 1st line anti-programmed death-1 (anti-PD1) monotherapy discontinuation.
Ochenduszko, Sebastian; (...); Maestu, Inmaculada
Meeting Abstract. 2022
Redefining radiologic responses (RR) in solid tumors: Shall we brace ourselves for a post-RECIST era? Results from a randomized clinical trial (RCT) on neoadjuvant chemotherapy in high-risk soft-tissue sarcomas (HR-STS) of the trunk or extremities
Vanzulli, Andrea; (...); Gronchi, Alessandro
Meeting Abstract. https://doi.org/10.1200/JCO.2024.42.16_suppl.11553. 2024
Redefining radiologic responses in high-risk soft-tissue sarcomas treated with neoadjuvant chemotherapy: final results of ISG-STS 1001, a randomized clinical trial.
Vanzulli, A; (...); Gronchi, A
Article. 10.1016/j.esmoop.2025.104299. 2025
Relevance of Reference Centers in Sarcoma Care and Quality Item Evaluation: Results from the Prospective Registry of the Spanish Group for Research in Sarcoma (GEIS).
Martin-Broto J; (...); Lopez-Pousa A
Article. 10.1634/theoncologist.2018-0121. 2019
Results of phase II randomized study of intermittent versus continuous schedule of vemurafenib plus cobimetinib in BRAF-mutated advanced melanoma.
Gonzalez-Cao, Maria; (...); Berrocal, Alfonso
Meeting Abstract. 10.1200/JCO.2021.39.15_suppl.9528. 2021
Risk assessment in brain-only oligometastatic non-small cell lung cancer (BOO-NSCLC) patients (pts): Recursive partioning analysis (RPA) model modification
Salvador Coloma, C.; (...); Juan-Vidal, O.
Meeting Abstract. 2018
RT after Encorafenib and Binimetinib on BRAF mutated melanoma brain metastases. GEM1802-Phase II
Alvarez, A.; (...); Marquez Rodas, I.
Meeting Abstract. 2023
Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.
Gounder, Mrinal M.; (...); Attia, Steven
Article. 10.1200/JCO.21.01829. 2022
Spatial distribution of tumour immune infiltrate predicts outcomes of patients with high-risk soft tissue sarcomas after neoadjuvant chemotherapy.
Pasquali, Sandro; (...); Gronchi, Alessandro
Article. 10.1016/j.ebiom.2024.105220. 2024
The ART-SCORE is not an effective tool for optimizing patient selection for DEB-TACE retreatment. A multicentre Spanish study
Pipa-Muniz, M; (...); Varela, M
Article. 10.1016/j.gastrohep.2017.05.009. 2017
Update of metastatic colorectal cancer metastases resection after FOLFIRI-aflibercept in oxaliplatin-refractory patients
Carmena, MD; (...); Martin, AM
Meeting Abstract. 10.1093/annonc/mdz155.189. 2019