Portal de recerca
- Inici
- Projectes i Estudis Clínics
- ESTUDIO DE FASE IB/IIA, ALEATORIZADO, DOBLE CIEGO, DE GRUPOS PARALELOS, CONTROLADO CON PLACEBO Y MULTICÉNTRICO PARA EVALUAR LA SEGURIDAD Y EFICACIA DE LAS CÉLULAS MADRE ALOGÉNICAS EXPANDIDAS DERIVADAS DEL TEJIDO ADIPOSO (EASCS) CX611 PARA EL TRATAMIENTO INTRAVENOSO DE PACIENTES ADULTOS CON NEUMONÍA BACTERIANA GRAVE ADQUIRIDA EN LA COMUNIDAD E INGRESADOS EN UNIDADES DE CUIDADOS INTENSIVOS ESTUDIO SEPCELL.
ESTUDIO DE FASE IB/IIA, ALEATORIZADO, DOBLE CIEGO, DE GRUPOS PARALELOS, CONTROLADO CON PLACEBO Y MULTICÉNTRICO PARA EVALUAR LA SEGURIDAD Y EFICACIA DE LAS CÉLULAS MADRE ALOGÉNICAS EXPANDIDAS DERIVADAS DEL TEJIDO ADIPOSO (EASCS) CX611 PARA EL TRATAMIENTO INTRAVENOSO DE PACIENTES ADULTOS CON NEUMONÍA BACTERIANA GRAVE ADQUIRIDA EN LA COMUNIDAD E INGRESADOS EN UNIDADES DE CUIDADOS INTENSIVOS ESTUDIO SEPCELL.
Dades bàsiques
- Protocol:
- CX611-0204
- EURDRACT:
- 2015-002994-39
- NCT:
- Centre:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Any inici:
- 2017
- Any de finalització:
- 2021
Documents
- No hi ha documents
Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
[Management of infectious complications associated with coronavirus infection in severe patients admitted to ICU].
Estella, Angel; (...); Zaragoza, Rafael
Article. 10.1016/j.medin.2021.04.007. 2021
[Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units].
Vidal-Cortes, Pablo; (...); Crespo, Rafael Zaragoza
Article. 10.1016/j.medin.2021.08.011. 2021
Acceptance and validity of the methods used to implement a competency based medical education programme in an Intensive Care Department of a teaching referral center.
Castellanos-Ortega, A.; (...); Garcia-Ros, R.
Article. 10.1016/j.medin.2019.12.007. 2021
Acceptance and validity of the methods used to implement a competency based medical education programme in an Intensive Care Department of a teaching referral center.
Castellanos-Ortega A; (...); García-Ros R
Article. 10.1016/j.medine.2019.12.011. 2021
Acute coronary syndrome due to a giant right coronary artery aneurysm
Villarreal, E, Jannone, R, Castellanos, A
Editorial Material. 10.1016/j.medin.2016.09.002. 2018
Acute respiratory distress syndrome due to COVID-19. Clinical and prognostic features from a medical Critical Care Unit in Valencia, Spain.
Ramírez P; (...); Castellanos Á
Article. 10.1016/j.medin.2020.06.015. 2021
An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital
Ruiz-Gaitan, A; (...); Peman, J
Article. 10.1111/myc.12781. 2018
Anti-endotoxin antibodies consumption in cardiovascular collapse: Pathophysiological concerns.
Villarreal, E.; (...); Vila, J.
Article. 10.1016/j.medine.2022.04.019. 2022
Antimicrobial Pharmacokinetics and Pharmacodynamics in Critical Care: Adjusting the Dose in Extracorporeal Circulation and to Prevent the Genesis of Multiresistant Bacteria.
Ruiz-Ramos, Jesus, Gras-Martin, Laura, Ramirez, Paula
Article. 10.3390/antibiotics12030475. 2023
Antimicrobial stewardship in hospitals: Expert recommendation guidance document for activities in specific populations, syndromes and other aspects (PROA-2) from SEIMC, SEFH, SEMPSPGS, SEMICYUC and SEIP.
Cercenado, Emilia; (...); Retamar-Gentil, Pilar
Practice Guideline. 10.1016/j.eimce.2022.05.013. 2023
Antimicrobial stewardship in hospitals: Expert recommendation guidance document for activities in specific populations, syndromes and other aspects (PROA-2) from SEIMC, SEFH, SEMPSPGS, SEMICYUC and SEIP
Cercenado, Emilia; (...); Retamar-Gentil, Pilar
Editorial Material. 10.1016/j.eimc.2022.05.005. 2023
Antimicrobial stewardship programme implementation in a medical ward
Ruiz, J; (...); Poveda, JL
Article. 2018
Antimicrobial stewardship programme in critical care medicine: A prospective interventional study
Ruiz, J; (...); Catellanos, A
Article. 10.1016/j.medin.2017.07.002. 2018
Antimicrobial stewardship programs in the intensive care unit in patients with infections caused by multidrug-resistant gram-negative bacilli
Ramos, J. Ruiz, Galleymore, P. Ramirez
Article. 10.1016/j.medin.2022.07.007. 2023
Antimicrobial stewardship programs in the Intensive Care Unit in patients with infections caused by multidrug-resistant Gram-negative bacilli.
Ruiz-Ramos J, Ramírez P
Article. 10.1016/j.medine.2022.09.004. 2022
Antisepsis for blood culture extraction. Blood culture contamination rate
Galleymore, PR, Sahuquillo, MG
Article. 10.1016/j.medin.2018.08.007. 2019
Beyond the Pandemic: The Value of Antimicrobial Stewardship
Kanj, Souha S., Ramirez, Paula, Rodrigues, Camilla
Article. 10.3389/fpubh.2022.902835. 2022
Biomarkers in pulmonary infections: a clinical approach.
Povoa, Pedro; (...); Kalil, Andre C
Article. 10.1186/s13613-024-01323-0. 2024
Biomarkers in the ICU: less is more? Yes.
Huang, David T., Ramirez, Paula
Editorial Material. 10.1007/s00134-020-06049-8. 2021
Cefiderocol pharmacokinetics in critically ill patients undergoing ECMO support.
Marín-Cerezuela M; (...); Ramirez P
Letter. 10.1186/s13054-024-05126-4. 2024
Ceftaroline versus standard therapy for pneumococcal meningitis in critically ill patients.
Martin-Cerezuela, M; (...); Galleymore, P R
Article. 10.1016/j.medin.2021.05.011. 2021
Ceftaroline versus standard therapy for pneumococcal meningitis in critically ill patients.
Martín-Cerezuela M; (...); Galleymore PR
Article. 10.1016/j.medine.2021.05.007. 2022
Ceftolozane/Tazobactam Dosing Requirements Against Pseudomonas aeruginosa Bacteremia.
Ruiz J; (...); Ramirez P
Article. 10.1177/1559325819885790. 2020
Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit
Garnacho-Montero, J; (...); GETGAG Study Grp
Article. 10.1016/j.jcrc.2018.08.017. 2018
Clinical characteristics, risk factors and management of patients with inflammatory bowel disease and hidradenitis suppurativa: a nationwide multicenter study of the GETECCU ENEIDA registry
Madero Velazquez, L.; (...); Gutierrez-Casbas, A.
Meeting Abstract. 2024
Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial
Cisneros, JM; (...); Magic Bullet Working Grp WP1
Article. 10.1186/s13054-019-2627-y. 2019
Current aspects in sepsis approach. Turning things around
Javier Candel, Francisco; (...); Vidal, Pablo
Review. 2018
Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults.
Vidal-Cortes, Pablo; (...); Zaragoza, Rafael
Review. 10.3390/antibiotics11091160. 2022
Daily bathing strategies and cross-transmission of multidrug-resistant organisms: Impact of chlorhexidine-impregnated wipes in a multidrug-resistant gram-negative bacteria endemic intensive care unit
Ruiz, J; (...); Castellanos-Ortega, A
Article. 10.1016/j.ajic.2017.06.029. 2017
Decolonization strategies against multidrug resistant organisms in the ICU.
Póvoa P, Ramirez P, Blot S
Editorial Material. 10.1007/s00134-024-07360-4. 2024
Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients A Randomized Clinical Trial
Wittekamp, BH; (...); Bonten, MJM
Article. 10.1001/jama.2018.13765. 2018
Design of a new mortality indicator in acute coronary syndrome on admission to the Intensive Care Unit.
Lozano Gomez, Herminia; (...); Araiz Burdio, Juan Jose
Article. 10.1016/j.medine.2023.03.008. 2023
Design of a new mortality indicator in acute coronary syndrome on admission to the Intensive Care Unit
Gomez, Herminia Lozano; (...); Araiz Burdio, Juan Jose
Article. 10.1016/j.medin.2023.02.002. 2023
Detection and treatment of Candida auris in an outbreak situation: risk factors for developing colonization and candidemia by this new species in critically ill patients
Ruiz-Gaitan, Alba; (...); Peman, Javier
Article. 10.1080/14787210.2019.1592675. 2019
Determination of meropenem in endotracheal tubes by in-tube solid phase microextraction coupled to capillary liquid chromatography with diode array detection
Hakobyan, L; (...); Campins-Falco, P
Article. 10.1016/j.jpba.2018.01.006. 2018
Diagnosis and treatment of catheter-related bloodstream infection: Clinical guidelines of the Spanish Society of Infectious Diseases and Clinical Microbiology and (SEIMC) and the Spanish Society of Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC).
Chaves F; (...); Valles J
Article. 10.1016/j.medin.2017.09.012. 2018
Effect of pharmacokinetic/pharmacodynamic ratio on tigecycline clinical response and toxicity in critically ill patients with multidrug-resistant Gram-negative infections
Ruiz, J; (...); Castellanos-Ortega, A
Article. 10.1177/2050312120958897. 2020
Efficacy and Experience of Bacteriophages in Biofilm-Related Infections.
Gordon, Monica, Ramirez, Paula
Article. 10.3390/antibiotics13020125. 2024
Epidemiology and clinical features caused by Candida auris in the setting of a prolonged outbreak
Meeting Abstract. 2017
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia.
Ceccato, Adrian; (...); Artigas, Antonio
Article. 10.3390/biomedicines11102676. 2023
Executive summary: Diagnosis and Treatment of Catheter-Related Bloodstream Infection: Clinical Guidelines of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) and the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC)
Chaves, F; (...); Valles, J
Article. 10.1016/j.eimc.2017.10.019. 2018
Fosfomycin in infections caused by multidrug-resistant Gram-negative pathogens.
Ruiz Ramos J, Salavert Lletí M
Article. 2019
Four cases of unexpected severe community-acquired pneumonia aetiology: Group A Streptococcus pyogenes disruption
Talavera, Monica; (...); Ramirez, Paula
Letter. 10.1016/j.medin.2023.04.013. 2023
Four cases of unexpected severe community-acquired pneumonia aetiology: Group A Streptococcus pyogenes disruption.
Talavera, Monica; (...); Ramirez, Paula
Case Reports. 10.1016/j.medine.2023.05.004. 2023
Fungal co-infection in COVID-19 patients: Should we be concerned?
Pemán J; (...); Quindós G
Review. 10.1016/j.riam.2020.07.001. 2020
Haemodialysis significantly reduces serum levetiracetam levels inducing epileptic seizures: Case report
Company-Albir, MJ; (...); Poveda, JL
Article. 10.1111/jcpt.12568. 2017
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians.
Povoa, Pedro; (...); Kalil, Andre C.
Article. 10.1007/s00134-022-06956-y. 2023
Impact of amikacin pharmacokinetic/pharmacodynamic index on treatment response in critically ill patients
Ruiz, J; (...); Castellanos-Ortega, A
Article. 10.1016/j.jgar.2017.09.019. 2018
Impact of an antimicrobial stewardship program on critical haematological patients.
Ruiz-Ramos, J; (...); Ramirez, P
Article. 10.7399/fh.2017.41.4.10709. 2017
Impact of the "Zero Resistance" program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study.
Álvarez-Lerma F; (...); Martínez-Alonso M
Article. 10.1016/j.medine.2022.12.002. 2023
Impact of the ?Zero Resistance? program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study
Alvarez-Lerma, Francisco; (...); Martinez-Alonso, Montserrat
Article. 10.1016/j.medin.2022.12.002. 2023
Impact of voriconazole plasma concentrations on treatment response in critically ill patients
Ruiz, J; (...); Ramirez, P
Article. 10.1111/jcpt.12817. 2019
Implication of Haemodiafiltration Flow Rate on Amikacin Pharmacokinetic Parameters in Critically Ill Patients
Ruiz-Ramos, J; (...); Ramirez, P
Article. 10.1159/000478969. 2018
In vitro study of antimicrobial activity on Klebsiella Pneumoniae biofilms in endotracheal tubes
Ruiz, J; (...); Ramirez, P
Article. 10.1080/1120009X.2019.1601801. 2019
Individualised antimicrobial dosing in critically ill patients undergoing continuous renal replacement therapy: focus on total drug clearance
Ruiz, J; (...); Ramirez, P
Article. 10.1136/ejhpharm-2016-001114. 2018
Influence of antibiotic pressure on multi-drug resistant Klebsiella pneumoniae colonisation in critically ill patients
Ruiz, J; (...); Ramirez, P
Article. 10.1186/s13756-019-0484-8. 2019
Influence of pharmacokinetic/pharmacodynamic ratio on vancomycin treatment response in paediatric patients with Staphylococcus aureus bacteremia.
Ruiz J; (...); Poveda JL
Article. 10.23736/S0026-4946.18.04978-2. 2018
Initial Antifungal Strategy Reduces Mortality in Critically Ill Patients With Candidemia: A Propensity Score-Adjusted Analysis of a Multicenter Study*
Garnacho-Montero, J; (...); Garcia-Garmendia, JL
Article. 10.1097/CCM.0000000000002867. 2018
Invasive aspergillosis in critically ill patients
Ramirez, P, Garnacho-Montero, J
Review. 10.1016/j.riam.2018.07.001. 2018
Lower Respiratory Tract Infection and Short-Term Outcome in Patients With Acute Respiratory Distress Syndrome.
Zampieri FG; (...); TAVeM study group
Article. 10.1177/0885066618772498. 2018
Lymphocyte Subpopulations in Community-Acquired Pneumonia: Role of Cell-Mediated Immunity
Mendez, R; (...); Menendez, R
Meeting Abstract. 2018
Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality
Mendez, R; (...); Torres, A
Article. 10.1016/j.jinf.2019.04.006. 2019
Management of infectious complications associated with coronavirus infection in severe patients admitted to ICU.
Estella, A; (...); Zaragoza, R
Article. 10.1016/j.medine.2021.08.013. 2021
MINIMALLY INVASIVE VERSUS OPEN HYSTERECTOMY IN HIGH-RISK ENDOMETRIAL CANCER: A PROPENSITY SCORE MATCHING ANALYSIS
Segarra Vidal, B.; (...); Ramirez, P.
Meeting Abstract. 10.1136/ijgc-2021-ESGO.206. 2021
Monographic: antisepsis in the critical patient Introduction
Ramirez, P., Nuvials, X., Diaz, E.
Editorial Material. 10.1016/j.medin.2018.07.018. 2019
New evidence in severe pneumonia: meropenem-vaborbactam.
Forteza Guillot, Maria, Martin Cerezuela, Maria, Ramirez, Paula
Article. 10.37201/req/s01.10.2022. 2022
Outbreak of Candida auris in Spain: A comparison of antifungal activity by three methods with published data
Ruiz-Gaitan, AC; (...); Peman, Javier
Article. 10.1016/j.ijantimicag.2019.02.005. 2019
OUTCOMES FOLLOWING OPEN RADICAL HYSTERECTOMY AFTER IMPLEMENTATION OF AN ENHANCED RECOVERY AFTER SURGERY (ERAS) PROGRAM
Agusti, N.; (...); Ramirez, P.
Meeting Abstract. 10.1136/ijgc-2021-ESGO.67. 2021
Pharmacokinetics of Amikacin in Critical Care Patients on Extracorporeal Device
Ruiz-Ramos, J; (...); Castellanos-Ortega, A
Article. 10.1097/MAT.0000000000000689. 2018
Practical document on the management of hyponatremia in critically ill patients
Porcar, MJB; (...); Herrera-Gutierrez, ME
Article. 10.1016/j.medin.2018.12.002. 2019
Recomendaciones GEMICOMED/GEIRAS-SEIMC para el manejo de las infecciones y colonizaciones por Candida auris.
Alastruey-Izquierdo A; (...); en nombre de GEMICOMED GEIRAS-SEIMC
Abstract of Published Item. 10.1016/j.riam.2019.06.001. 2019
Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units.
Vidal-Cortés P; (...); Zaragoza Crespo R
Practice Guideline. 10.1016/j.medine.2021.11.019. 2022
Reply to: "ormothermic regional perfusion - What is the benefit?''
Hessheimer, AJ; (...); Fondevila, C
Letter. 10.1016/j.jhep.2019.04.005. 2019
Risk of immunomediated adverse events or secondary loss of response to infliximab in elderly patients with inflammatory bowel disease: a cohort study of the ENEIDA registry
Calafat, M; (...); Domenech, E
Meeting Abstract. 10.1093/ecco-jcc/jjy222.561. 2019
Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit.
Martín-Cerezuela M; (...); Ramírez-Galleymore P
Article. 10.1186/s13054-023-04347-3. 2023
Soluble urokinase plasminogen activator receptor (suPAR) for the prediction of ventilator-associated pneumonia (VAP)
van Oort, PMP; (...); Martin-Loeches, I
Meeting Abstract. 10.1183/13993003.congress-2018.PA2607. 2018
Soluble urokinase plasminogen activator receptor for the prediction of ventilator-associated pneumonia.
van Oort PM; (...); Martin-Loeches I
Article. 10.1183/23120541.00212-2018. 2019
Ten Issues to Update in Nosocomial or Hospital-Acquired Pneumonia: An Expert Review.
Candel, Francisco Javier; (...); Zaragoza, Rafael
Article. 10.3390/jcm12206526. 2023
Textbook outcome in patients with biliary duct injury during cholecystectomy.
Lopez-Lopez V; (...); Robles-Campos R
Article. 10.1016/j.gassur.2024.02.027. 2024
The challenge of multiresistant microorganisms.
Vicent C, Ramírez P
Editorial Material. 10.1016/j.medcli.2023.12.004. 2024
The UK DCD Risk Score: Still no consensus on futility in DCD liver transplantation
Hessheimer, AJ; (...); Fondevila, C
Letter. 10.1016/j.jhep.2019.01.004. 2019
Time-kill assays of amphotericin B plus anidulafungin against Candida tropicalis biofilms formed on two different biomaterials
Fernandez-Rivero, ME; (...); Canton, E
Article. 10.5301/ijao.5000652. 2018
Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia
Almansa, R; (...); Martin-Loeches, I
Article. 10.21037/atm.2018.05.12. 2018
Transcriptomics reveals shared immunosuppressive landscapes in ventilator-associated lower respiratory tract infections (VA-LRTI) patients.
Martin-Loeches I; (...); Bermejo-Martín JF
Article. 10.1080/14787210.2023.2256979. 2023
Treatment of critically ill patients with cefiderocol for infections caused by multidrug-resistant pathogens: review of the evidence.
Viale, Pierluigi; (...); Lodise, Thomas P.
Article. 10.1186/s13613-023-01146-5. 2023
Update of the treatment of nosocomial pneumonia in the ICU
Zaragoza, R; (...); Martin-Loeches, I
Review. 10.1186/s13054-020-03091-2. 2020
Vancomycin and daptomycin minimum inhibitory concentrations as a predictor of outcome of methicillin-resistant Staphylococcus aureus bacteraemia
Ruiz, J; (...); Castellanos-Ortega, A
Article. 10.1016/j.jgar.2018.03.007. 2018
Vasopressin antagonist efficacy and safety in volume-overloaded critically ill patients: a new therapeutic alternative
Ruiz-Ramos, J; (...); Castellanos-Ortega, A
Article. 10.1136/ejhpharm-2018-001664. 2020