Portal de investigación
ESTUDIO DE OBSERVACIÓN MULTICÉNTRICO, PROSPECTIVO Y MULTINACIONAL PARA EVALUAR LA SEGURIDAD A LARGO PLAZO DE ESMYA, ESPECIALMENTE LA SEGURIDAD ENDOMETRIAL, Y LOS PATRONES DE PRESCRIPCIÓN Y GESTIÓN ACTUALES DE ESMYA EN EL CONTEXTO DE UN TRATAMIENTO A LARGO PLAZO.
Datos básicos
- Protocolo:
- PRE-ULI-2015-01
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2016
- Año de finalización:
- 2024
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
5-aza-2 '-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/beta-catenin pathway in human uterine leiomyomas
Carbajo-García MC; (...); Ferrero H
Article. 10.1186/s12958-021-00790-5. 2021
Correlation of Methylation Status and Gene Expression Shows Epigenetics Involvement in Key Biological Processes of Uterine Leiomyoma Development.
Carbajo-Garcia, MC; (...); Ferrero, Hortensia
Meeting Abstract. 2021
Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.3390/biomedicines10061279. 2022
Diagnostic evaluation of uterine myomas.
Olalla S; (...); Cañete ML
Article. 10.1016/j.ejogrb.2020.02.023. 2020
Effects of Vitamin D in Human Uterine Leiomyoma Growth in a Xenograft Animal Model.
Corachan, A; (...); Pellicer, A
Meeting Abstract. 2019
Epidemiology of uterine myomas and clinical practice in Spain: An observational study
Monleon, J; (...); EME Study Grp
Article. 10.1016/j.ejogrb.2018.05.026. 2018
Evaluación del dolor en niños de 2, 4 y 6 meses tras la aplicación de métodos de analgesia no farmacológica durante la vacunación.
Nieto García A; (...); Picó Sirvent L
Abstract of Published Item. 10.1016/j.anpedi.2018.10.002. 2019
H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/beta-catenin and TGF-beta pathways.
Carbajo-García MC; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01060-2. 2023
Histone deacetylase inhibition by suberoylanilide hydroxamic acid: a therapeutic approach to treat human uterine leiomyoma.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.1016/j.fertnstert.2021.10.012. 2022
In Silico Saturation Mutagenesis Identifies Novel Driver Genes in Uterine Fibroids
Machado-Lopez, Alba; (...); Mas, Aymara
Meeting Abstract. 2022
In vitro proliferation of uterine fibroids is related with vitamin D receptor and patient's age
Garcia, N; (...); Pellicer, A
Meeting Abstract. 2017
Inhibition of cell proliferation and extracellular matrix formation in human uterine leiomyomas by 5-aza-2 '-deoxycitidine via Wnt/beta-catenin pathway
Carbajo-Garcia, MC; (...); Ferrero, H
Meeting Abstract. 2021
Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/ß-catenin pathway.
Corachán A; (...); Pellicer A
Article. 10.1016/j.fertnstert.2018.10.008. 2019
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix and vesicles.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.1002/path.5920. 2022
Integrative Genomic and Transcriptomic Profiling Reveals a Differential Molecular Signature in Uterine Leiomyoma versus Leiomyosarcoma.
Machado-Lopez A; (...); Mas A
Article. 10.3390/ijms23042190. 2022
Integrative Molecular Profiling of Uterine Leiomyomas and Leiomyosarcomas Using DNA and RNA Sequencing: Preliminary Steps Toward Preoperative Differential Diagnosis.
Mas, Aymara; (...); Simon, Carlos
Meeting Abstract. 2020
Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model.
Corachán A; (...); Pellicer A
Article. 10.1016/j.fertnstert.2019.09.018. 2020
Potential Role of Nervous System Related Functions in Uterine Leiomyoma Pathogenesis
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Meeting Abstract. 2022
SINGLE CELL RNASEQ ANALYSES OF UTERINE FIBROIDS AND FIBROID-FREE MYOMETRIA REVEAL PREVIOUSLY UNIDENTIFIED CELL TYPE AND STATE.
Wang, WX; (...); Simon, C
Meeting Abstract. 10.1016/j.fertnstert.2019.07.1001. 2019
SINGLE CELL TRANSCRIPTOMES FROM UTERINE FIBROIDS AND FIBROID-FREE MYOMETRIUM ELUCIDATE MYOMETRIAL TUMORIGENESIS.
Wang, WX; (...); Simon, C
Meeting Abstract. 2020
Single Cell Transcriptomes From Uterine Fibroids and Fibroid-free Myometrium Elucidate Myometrial Tumorigenesis.
Wang, WX; (...); Simon, C
Meeting Abstract. 2020
Single Cell Transcriptomes from Uterine Fibroids and Fibroid-Free Myometrium Elucidate Myometrial Tumorigenesis.
Wang, WX; (...); Simon, C
Meeting Abstract. 2021
The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing
Mas, A; (...); Simon, C
Article. 10.1016/j.ajog.2019.05.018. 2019
Updated approaches for management of uterine fibroids.
Mas, A; (...); Monleon, J
Article. 10.2147/IJWH.S138982. 2017
Uterine fibroid surgical treatment
Satorres, Elena; (...); Monleon, Javier
Editorial Material. 10.1016/j.medcli.2023.07.008. 2023
Validation of the Spanish version of the Uterine Fibroid Symptom and Quality of Life (UFS-QoL) questionnaire in women with uterine myomatosis.
Calaf J; (...); Vázquez F
Article. 10.1016/j.medcli.2019.05.027. 2020
Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation.
Corachán A; (...); Ferrero H
Article. 10.1016/j.fertnstert.2020.07.049. 2020
Vitamin D as an effective treatment to reduce cell proliferation and extracellular matrix formation in human uterine leiomyomas regardless MED12 mutation status
Corachan, A; (...); Ferrero, H
Meeting Abstract. 2020
Vitamin D can inhibit proliferation of uterine fibroid cells in vitro through the Wnt/beta-Catenin signalling pathway
Corachan, A; (...); Pellicer, A
Meeting Abstract. 2017
VITAMIN D LONG-TERM TREATMENT DECREASES HUMAN UTERINE LEIOMYOMA SIZE THROUGH SPECIFIC MOLECULAR MECHANISMS IN A XENOGRAFT ANIMAL MODEL.
Corachan, A; (...); Pellicer, A
Meeting Abstract. 10.1016/j.fertnstert.2019.07.347. 2019