Portal de investigación
Generation of a biological product based on angiogenic extracellular vesicles from genetically modified mesenchymal stem cells for the treatment of cardio-vascular diseases (gevecar).
Datos básicos
- Protocolo:
- PI19/00245
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2020
- Año de finalización:
- 2022
Documentos
- No hay documentos
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration
Gil-Castell, O.; (...); Ribes-Greus, A.
Article. 10.1016/j.reactfunctpolym.2021.105064. 2022
A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
de la Fuente, Ana; (...); Ravassa, Susana
Article. 10.3390/cancers14122941. 2022
A predictive model for prostate cancer incorporating PSA molecular forms and age.
Oto J; (...); Navarro S
Article. 10.1038/s41598-020-58836-4. 2020
Acute Kidney Injury After Percutaneous Edge-to-Edge Mitral Repair.
Armijo G; (...); Nombela-Franco L
Article. 10.1016/j.jacc.2020.09.582. 2020
Analysis of Juvenile Onset Pompe Disease patients included in the Spanish Pompe Registry
Martinez Marin, R.; (...); Diaz Manera, J.
Meeting Abstract. 2022
Analysis of Juvenile onset Pompe disease patients included in the Spanish Pompe Registry
Martinez Marin, R.; (...); Diaz Manera, J.
Meeting Abstract. 10.1016/j.nmd.2022.07.144. 2022
ATR-FTIR spectroscopy for the routine quality control of exosome isolations
Ramos-Garcia, V; (...); Kuligowski, J
Article. 10.1016/j.chemolab.2021.104401. 2021
Cardiopulmonary Rehabilitation Improves Respiratory Muscle Function and Functional Capacity in Children with Congenital Heart Disease. A Prospective Cohort Study
Ferrer-Sargues FJ; (...); Iranzo, MACI
Article. 10.3390/ijerph17124328. 2020
Clinical and echocardiographic outcomes of transcatheter mitral valve repair in atrial functional mitral regurgitation.
Benito-González T; (...); Fernández-Vázquez F
Article. 10.1016/j.ijcard.2021.09.056. 2021
Clinical Characteristics and Outcomes of Patients With COVID-19 and STEMI Treated With Fibrinolytic Therapy
Hamadeh, A; (...); McCullough, P
Meeting Abstract. 2020
Co-administration of human MSC overexpressing HIF-1a increases human CD34(+) cell engraftment in vivo.
Preciado S; (...); Sánchez-Guijo F
Article. 10.1186/s13287-021-02669-z. 2021
Consensus document for anaesthesiologist-assisted sedation in interventional cardiology procedures
Martinez-Dolz, L; (...); Alvarez, J
Article. 10.1016/j.redar.2021.01.001. 2021
Consequences of canceling elective invasive cardiac procedures during Covid-19 outbreak.
Moreno R; (...); Paredes E
Article. 10.1002/ccd.29433. 2021
Controlled Donation After Circulatory Death Pancreas Transplantation in Spain. Initial Experience
Ferrer-Fabrega, J.; (...); Dominguez-Gil, B.
Meeting Abstract. 2021
Coronary physiology at the cath lab
Vilchez-Tschischke, Jean Paul; (...); Garcia-Garcia, Hector M.
Review. 10.24875/RECICE.M22000328. 2022
Corrigendum to "Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation".
Ontoria-Oviedo I; (...); Sepúlveda P
Correction. 10.1155/2022/9786160. 2022
COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction.
De Luca G; (...); Collaborators
Article. 10.1136/heartjnl-2021-319750. 2022
Changes in sleep-disordered breathing from the acute to the stable phase of pulmonary embolism and impact of right ventricular dysfunction: preliminary findings of ESAET study
Ortega, AG; (...); Martinez-Garcia, MA
Meeting Abstract. 10.1183/13993003.congress-2020.4974. 2020
Characteristics and Outcomes in Patients Presenting With COVID-19 and ST-Segment Elevation Myocardial Infarction
Hamadeh A; (...); McCullough PA
Article. 10.1016/j.amjcard.2020.06.063. 2020
Characterization of hiPSC-CMs derived from pediatric cancer patients treated with anthracyclines that suffered cardiotoxicity
Reinal, I.; (...); Sepulveda, P.
Meeting Abstract. 2021
Design and rationale for a real-world prospective, multicenter registry of myocardial revascularization failure and secondary revascularization: The REVASEC study.
Salinas P; (...); Escaned J
Article. 10.1016/j.carrev.2021.11.015. 2021
EVs derived from HIF-overexpressing MSC primed with a pro-inflammatory cocktail promote M2 macrophage polarization and reduce fibrosis and endothelium activation in vitro and in a mouse ulcerous colitis model.
Gomez-Ferrer, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Extrathoracic Aneurysms in Marfan Syndrome: A Systematic Review of the Literature.
Requejo-Garcia, Lucia; (...); Miralles-Hernandez, Manuel
Article. 10.1016/j.avsg.2022.08.005. 2022
Genotype FBN1/Phenotype relationship in a cohort of patients with Marfan syndrome.
Hernándiz A; (...); Sepúlveda P
Article. 10.1111/cge.13879. 2020
HIF-1 alpha and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles
Gomez-Ferrer, M; (...); Dorronsoro, A
Article. 10.3390/ijms22073416. 2021
HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn's Disease.
Gómez-Ferrer M; (...); Sepúlveda P
Article. 10.3390/ijms222011269. 2021
Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients
Plana E; (...); Miralles M
Article. 10.3390/ijms21134600. 2020
Impact of COVID-19 pandemic and diabetes on mechanical reperfusion in patients with STEMI: insights from the ISACS STEMI COVID 19 Registry.
De Luca G; (...); Verdoia M
Article. 10.1186/s12933-020-01196-0. 2020
Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI.
De Luca G; (...); Dudek D
Article. 10.1016/j.jacc.2020.09.546. 2020
Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry
De Luca, Giuseppe; (...); Verdoia, Monica
Article. 10.1186/s12931-022-02128-0. 2022
Impact of diabetes in patients waiting for invasive cardiac procedures during COVID-19 pandemic
Moreno, R; (...); Paredes, E
Article. 10.1186/s12933-021-01261-2. 2021
Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry
De Luca, Giuseppe; (...); Vavlukis, Marija
Article. 10.1016/j.atherosclerosis.2021.06.926. 2021
Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry
De Luca G; (...); Verdoia M
Article. 10.3390/jcm11226722. 2022
Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C
Martos L; (...); Medina P
Article. 10.3390/ijms21165651. 2020
Intracellular role of IL - 6 in mesenchymal stromal cell immunosuppression and proliferation
Dorronsoro, Akaitz; (...); Trigueros C
Article. 2020
Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation.
Dorronsoro, Akaitz; (...); Trigueros, Cesar
Article. 10.1038/s41598-020-78864-4. 2020
Isolation of extracellular vesicles derived from mesenchymal stem cells by ultracentrifugation and tangential flow filtration followed by size-exclusion chromatography: a functional comparison
Amaro-Prellezo, E.; (...); Sepulveda, P.
Meeting Abstract. 2021
Massive Primary Mitral Regurgitation Due to Chordae Rupture: Treatment With New-Generation Edge-to-Edge Repair Devices.
Vilchez-Tschischke JP; (...); Diez-Gil JL
Editorial Material. 10.1016/j.jcin.2020.12.026. 2021
microRNAs and Markers of Neutrophil Activation as Predictors of Early Incidental Post-Surgical Pulmonary Embolism in Patients with Intracranial Tumors
Article. 10.3390/cancers12061536. 2020
MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
Article. 10.3390/ijms21030840. 2020
miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia
Sánchez-Sánchez R; (...); Sepúlveda P
Article. 10.3389/fcell.2021.734143. 2021
miRNA-4732-3p as a possible therapeutic tool for the treatment of myocardial ischemia
Sanchez-Sanchez, R.; (...); Sepulveda, P.
Meeting Abstract. 2021
Modeling Transposition of the Great Arteries with Patient-Specific Induced Pluripotent Stem Cells.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms222413270. 2021
Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.
Verheijen, Marcha; (...); HeCaToS Consortium
Article. 10.1038/s41597-022-01825-1. 2022
Non-classical Notch signaling by MDA-MB-231 breast cancer cell-derived small extracellular vesicles promotes malignancy in poorly invasive MCF-7 cells.
Gonzalez-King, Hernan; (...); Garcia, Nahuel A.
Article. 10.1038/s41417-021-00411-8. 2022
Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome
Fernandez-Santos, Maria Eugenia; (...); Zapata, Agustin G.
Article. 10.3389/fimmu.2022.918565. 2022
Over-Expression of HIF-1A In Mesenchymal Stromal Cells Increases Human CD34+Cells Clonogenic Capacity in Vitro And Engraftment Ability in A Xenotransplantation Model
Preciado, S; (...); Sanchez-Guijo, F
Meeting Abstract. 2021
Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device.
Freixa X; (...); Arzamendi D
Article. 10.3390/jcm10040734. 2021
Periodontal disease and gestational diabetes mellitus: a case-control study
Estevez Llorens, R.; (...); Perales Marin, A.
Article. 10.1016/j.gine.2021.100675. 2021
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice.
Lerida-Viso, Araceli; (...); Martinez-Manez, Ramon
Article. 10.1016/j.phrs.2022.106356. 2022
Physiology-guided revascularization versus optimal medical therapy of nonculprit lesions in elderly patients with myocardial infarction: Rationale and design of the FIRE trial.
Biscaglia S; (...); Campo G
Article. 10.1016/j.ahj.2020.08.007. 2020
Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation.
Ontoria-Oviedo I; (...); Sepúlveda P
Article. 10.1155/2020/8872009. 2020
Platelet rich plasma and plasma rich in growth factors for split-thickness skin graft donor site treatment in the burn patient setting: A randomized clinical trial.
García-Sánchez JM; (...); Pérez-Del-Caz MD
Article. 10.1016/j.burns.2021.10.001. 2021
Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury.
Tejedor S; (...); Vicent MJ
Article. 10.1002/adhm.202002121. 2021
Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure
Trejo-Velasco, B; (...); Cruz-Gonzalez, I
Article. 10.3390/jcm10051006. 2021
Prognostic value and clinical predictors of intramyocardial hemorrhage measured by CMR T2* sequences in STEMI.
Ferré-Vallverdú M; (...); Igual-Muñoz B
Article. 10.1007/s10554-020-02142-7. 2021
Rationale and Design of the Dapagliflozin after Transcatheter Aortic Valve Implantation (DapaTAVI) randomized trial.
Amat-Santos IJ; (...); Raposeiras-Roubín S
Article. 10.1002/ejhf.2370. 2021
Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic.
De Luca G; (...); Verdoia M
Article. 10.1016/j.deman.2021.100022. 2021
Similar degree of intimal coverage and apposition among drug-eluting stents with persistent, absorbable or without polymer at 1 and 6 months after implantation
Fernandez, AC; (...); Vaquerizo, B
Meeting Abstract. 2020
Subtype-specific differentiation of atrial and ventricular cardiomyocytes from human iPSCs
Casini, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Temporal trend and potential impact of angiotensin receptor neprilysin inhibitors on transcatheter edge-to-edge mitral valve repair.
Barrero, Alejandro; (...); Spanish TEER Group
Article. 10.1016/j.rec.2022.02.001. 2022
The Vascular Niche for Adult Cardiac Progenitor Cells.
Herrero, Diego; (...); Bernad, Antonio
Article. 10.3390/antiox11050882. 2022
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms23179918. 2022
Transcatheter mitral repair according to the cause of mitral regurgitation: real-life data from the Spanish MitraClip registry
Pascual, Isaac; (...); Estevez-Loureiro, Rodrigo
Article. 10.1016/j.recesp.2019.07.014. 2020
Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study
Pascual, I; (...); Estevez-Loureiro, R
Article. 10.3390/jcm9061792. 2020
Two-component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen
Martí-Centelles, Rosa; (...); Escuder, Beatriu
Article. 10.1021/acsabm.0c01422. 2021
Urinary microRNAs: Looking for a New Tool in Diagnosis, Prognosis, and Monitoring of Renal Cancer
Article. 10.1007/s11934-020-0962-9. 2020
Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study
Article. 10.1016/j.jprot.2020.103723. 2020