Portal de investigación
MINIMAL INVASIVE BIOMARKERS FOR THE PERSONALIZED TREATMENT OF NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY (HIE). (CONTRATO)
Datos básicos
- Código:
- MS16/00034
- Protocolo:
- MS16/00034
- EUDRACT:
- NCT:
- Centro:
- Dotación:
- 219.802,00 €
- Año de incio:
- 2017
- Año de finalización:
- 2022
Objetivos del proyecto
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Documentos
- No hay documentos
Participantes
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Financiadores - Promotores
Resultados del Ensayo Clínico
A Reductive Metabolic Switch Protects Infants with Transposition of Great Arteries Undergoing Atrial Septostomy against Oxidative Stress.
Pineiro-Ramos, Jose David; (...); Vento M
Article. 10.3390/antiox10101502. 2021
A UPLC-MS/MS method for the determination of oxidative stress biomarkers in amniotic fluid.
Cascant-Vilaplana MM; (...); Vento, Maximo
Article. 10.1016/j.freeradbiomed.2021.12.310. 2022
Adrenic acid non-enzymatic peroxidation products in biofluids of moderate preterm infants.
Sánchez-Illana Á; (...); Kuligowski J
Article. 10.1016/j.freeradbiomed.2019.02.024. 2019
Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients.
Horta D; (...); Calvet X
Article. 10.1021/acs.jproteome.0c00462. 2021
Assessment of discriminant models in infrared imaging using constrained repeated random sampling - Cross validation.
Perez-Guaita, D; (...); Quintas, G
Article. 10.1016/j.aca.2018.05.019. 2018
Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study
Sanchez-Illana, A; (...); Kuligowski, J
Article. 10.1038/srep40315. 2017
ATR-FTIR spectroscopy for the routine quality control of exosome isolations
Ramos-Garcia, V; (...); Kuligowski, J
Article. 10.1016/j.chemolab.2021.104401. 2021
ATR-Spin: an open-source 3D printed device for direct cytocentrifugation onto attenuated total reflectance crystals.
Pérez-Guaita D; (...); Wood B
Article. 10.1039/d1lc00813g. 2021
Biomarkers of oxidative stress derived damage to proteins and DNA in human breast milk
Sanchez-Illana, A; (...); Kuligowski, J
Article. 10.1016/j.aca.2018.01.054. 2018
Biomonitoring of bisphenols A, F, Sin human milk and probabilistic risk assessment for breastfed infants
Dualde, P; (...); Yusa, V
Article. 10.1016/j.scitotenv.2019.03.024. 2019
Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants.
Dualde, P; (...); Yusa, V
Article. 10.1016/j.chemosphere.2019.124829. 2020
Biomonitoring of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in human milk: Exposure and risk assessment for lactating mothers and breastfed children from Spain
Hernandez, CS; (...); BETTERMILK
Article. 10.1016/j.scitotenv.2020.140710. 2020
Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease-A Retrospective, Case-Control Pilot Study.
Escobar-Diaz, Maria C.; (...); Camprubi-Camprubi, Marta
Article. 10.3390/antiox11020299. 2022
Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics
Ten-Domenech, I; (...); Kuligowski, J
Article. 10.3390/metabo10040126. 2020
Current Practice in Untargeted Human Milk Metabolomics.
Ten-Doménech I; (...); Quintás G
Review. 10.3390/metabo10020043. 2020
Direct Derivatization in Dried Blood Spots for Oxidized and Reduced Glutathione Quantification in Newborns.
Ten-Domenech, Isabel; (...); Kuligowski, Julia
Article. 10.3390/antiox11061165. 2022
Discriminant analysis and feature selection in mass spectrometry imaging using constrained repeated random sampling - Cross validation (CORRS-CV)
Perez-Guaita, D, Quintas, G, Kuligowski, J
Article. 10.1016/j.aca.2019.10.039. 2020
Do levels of lipid peroxidation biomarkers reflect the degree of brain injury in newborns?
Cascant-Vilaplana, Mari Merce; (...); Vento, Maximo
Article. 10.1089/ars.2021.0168. 2021
Does Pasteurized Donor Human Milk Efficiently Protect Preterm Infants Against Oxidative Stress?
Parra-Llorca, A; (...); Vento, M
Article. 10.1089/ars.2019.7821. 2019
Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants
Pinilla-Gonzalez, Alejandro; (...); Cernada, Maria
Article. 10.1038/s41390-022-02271-w. 2023
Effect of a Marathon on Skin Temperature Response After a Cold-Stress Test and Its Relationship With Perceptive, Performance, and Oxidative-Stress Biomarkers
Priego-Quesada, JI; (...); Palmer, RS
Article. 10.1123/ijspp.2019-0963. 2020
Effect of donor human milk on host-gut microbiota and metabolic interactions in preterm infants.
Piñeiro-Ramos JD; (...); Vento M
Article. 10.1016/j.clnu.2020.08.013. 2020
Evaluation of batch effect elimination using quality control replicates in LC-MS metabolite profiling
Sanchez-Illana, Angel; (...); Kuligowski, Julia
Article. 10.1016/j.aca.2018.02.053. 2018
Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment
Sanchez-Illana, A; (...); HYPOTOP Study Group
Article. 10.1038/s41598-017-17202-7. 2017
Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring.
Coscollà C; (...); Yusà V
Article. 10.1002/etc.4996. 2021
External cavity-quantum cascade laser (EC-QCL) spectroscopy for protein analysis in bovine milk
Kuligowski, Julia; (...); Lendl, Bernhard
Article. 10.1016/j.aca.2017.02.003. 2017
Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.
Ten-Doménech I; (...); Kuligowski J
Article. 10.1016/j.aca.2021.339173. 2021
Fast quantification of bovine milk proteins employing external cavity-quantum cascade laser spectroscopy
Schwaighofer, A; (...); Lendl, B
Article. 10.1016/j.foodchem.2018.01.082. 2018
Fatty Acid Determination in Human Milk Using Attenuated Total Reflection Infrared Spectroscopy and Solvent-Free Lipid Separation.
Akhgar CK; (...); Lendl B
Article. 10.1177/00037028211065502. 2022
Feeding the preterm infant: an overview of the evidence.
Poulimeneas D; (...); NUTRISHIELD Consortium
Review. 10.1080/09637486.2020.1754352. 2021
Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes?
Teramo, Kari, Pineiro-Ramos, JD
Review. 10.1016/j.freeradbiomed.2019.03.012. 2019
GC-MS analysis of short chain fatty acids and branched chain amino acids in urine and faeces samples from newborns and lactating mothers.
Ramos-Garcia, Victoria; (...); Quintas, Guillermo
Article. 10.1016/j.cca.2022.05.005. 2022
Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies
Broadhurst, D; (...); Dunn, WB
Review. 10.1007/s11306-018-1367-3. 2018
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High and ultra-high definition of infrared spectral histopathology gives an insight into chemical environment of lung metastases in breast cancer
Augustyniak, K; (...); Malek, K
Article. 10.1002/jbio.201800345. 2019
High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest: A Post Hoc Analysis of the COMACARE Trial
Humaloja J; (...); Skrifvars MB
Article. 10.3390/jcm10184226. 2021
Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells.
Parra-Llorca A; (...); Vento M
Article. 10.3390/nu11112677. 2019
Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes
Pineiro-Ramos, JD; (...); Vento, M
Article. 10.3390/metabo10030109. 2020
Metabolomics, Oxidative, and Nitrosative Stress in the Perinatal Period.
Kuligowski, Julia, Vento, Maximo
Article. 10.3390/antiox11071357. 2022
Model selection for within-batch effect correction in UPLC-MS metabolomics using quality control - Support vector regression
Sanchez-Illana, A; (...); Kuligowski, J
Article. 10.1016/j.aca.2018.04.055. 2018
Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis.
Martínez-Sena T; (...); Kuligowski J
Article. 10.1038/s41598-019-46371-w. 2019
Monitoring of Urinary Oxidative Stress Biomarker Levels in Newborns with Hypoxic-Ischemic Encephalopathy
Vilaplana, MMC; (...); Kuligowski, Julia
Meeting Abstract. 10.1016/j.freeradbiomed.2020.10.291. 2020
NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes
Jenkins DD; (...); Wiest DB
Article. 10.3390/antiox10091344. 2021
Noninvasive monitoring of evolving urinary metabolic patterns in neonatal encephalopathy.
Piñeiro-Ramos JD; (...); Vento M
Article. 10.1038/s41390-021-01553-z. 2021
Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma
Sanchez-Illana, Angel; (...); Kuligowski, Julia
Article. 10.1016/j.aca.2017.09.026. 2017
On-Capillary Surface-Enhanced Raman Spectroscopy: Determination of Glutathione in Whole Blood Microsamples
Sanchez-Illana, Angel; (...); Kuligowski, Julia
Article. 10.1021/acs.analchem.8b01492. 2018
Oxidative stress biomarkers in the preterm infant.
Sánchez-Illana Á; (...); Kuligowski J
Review. 10.1016/bs.acc.2020.08.011. 2020
Oxygen and oxidative stress in the perinatal period
Torres-Cuevas, Isabel; (...); Vento, Maximo
Review. 10.1016/j.redox.2017.03.011. 2017
Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia
Kuligowskia, J; (...); Vento, M
Article. 10.1016/j.redox.2017.02.002. 2017
Plasma Metabolite Score Correlates with Hypoxia Time in a Newly Born Piglet Model for Asphyxia
Kuligowski, J; (...); Vento, M
Meeting Abstract. 2017
Protein Oxidation Biomarkers and Myeloperoxidase Activation in Cerebrospinal Fluid in Childhood Bacterial Meningitis.
Rugemalira E; (...); Vento M
Article. 10.3390/antiox8100441. 2019
Recent advancements of EC-QCL based mid-IR transmission spectroscopy of proteins and application to analysis of bovine milk
Schwaighofer, A; (...); Lendl, B
Article. 10.3233/BSI-180177. 2018
Small molecule biomarkers for neonatal hypoxic ischemic encephalopathy.
Sánchez-Illana Á, Piñeiro-Ramos JD, Kuligowski J
Review. 10.1016/j.siny.2020.101084. 2020
The effect of Holder pasteurization on the lipid and metabolite composition of human milk.
Ten-Domenech, Isabel; (...); Quintas, Guillermo
Article. 10.1016/j.foodchem.2022.132581. 2022
The Relationship between Oxidative Stress, Intermittent Hypoxemia, and Hospital Duration in Moderate Preterm Infants.
Shah VP; (...); Di Fiore JM
Article. 10.1159/000509038. 2020
Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial
Nunez-Ramiro, A; (...); Hypotop Study Grp
Article. 10.1159/000499084. 2019
Toward a Noninvasive, Label-Free Screening Method for Determining Spore Inoculum Quality of Penicillium chrysogenum Using Raman Spectroscopy
Wieland, K; (...); Lendl, B
Article. 10.1177/0003702817727728. 2017
Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy.
Pérez-Guaita D; (...); Castell JV
Article. 10.1021/acs.analchem.0c02735. 2020
Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates.
Cernada M; (...); Serna E
Article. 10.1038/s41390-021-01444-3. 2021