Portal de investigación
PAPEL PROTECTOR DE BH4 EN LA DISFUNCIÓN VENTRICULAR. UNA PROMETEDORA ESTRATEGIA TERAPÉUTICA EN LA
Datos básicos
- NumeroConcesion:
- CAS14/00111
- Año inicial:
- 2014
- Año final:
- 2015
Objetivos del proyecto
FINALIZADO
Documentos
- No hay documentos
Participantes
Financiadores
Resultados del Proyecto
20 years of leptin: Role of leptin in cardiomyocyte physiology and physiopathology
Feijóo-Bandín S; (...); Lago F
Review. 10.1016/j.lfs.2015.02.016. 2015
24 h nesfatin-1 treatment promotes apoptosis in cardiomyocytes
Feijóo-Bandín S; (...); Lago F
Editorial Material. 10.1007/s12020-015-0648-0. 2016
A clinical perspective on the utility of alpha 1 antichymotrypsin for the early diagnosis of calcific aortic stenosis
Martin-Rojas T; (...); Barderas MG
Article. 10.1186/s12014-017-9147-z. 2017
Adipokines and Inflammation: Focus on Cardiovascular Diseases.
Feijóo-Bandín S; (...); Lago F
Review. 10.3390/ijms21207711. 2020
Alpha-cardiac Actin Serum Expression Levels Detect Acute Cellular Rejection in Heart Transplant Patients.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.1097/TP.0000000000004273. 2022
Alteration in Golgi apparatus fragmentation related genes in human dilated cardiomyopathy.
Gonzalez-Torrent, Irene; (...); Rosello-Lleti, Esther
Article. 10.1038/s41598-025-92758-3. 2025
Alterations in Mitochondrial Oxidative Phosphorylation System: Relationship of Complex V and Cardiac Dysfunction in Human Heart Failure
Gimenez-Escamilla, Isaac; (...); Rosello-Lleti, Esther
Article. 10.3390/antiox13030285. 2024
Alterations in the Nucleocytoplasmic Transport in Heart Transplant Rejection.
Lozano-Edo, Silvia; (...); Martinez-Dolz, Luis
Article. 10.1016/j.transproceed.2021.09.003. 2021
Alterations of mitochondrial bioenergetics in human hearts with ischemic and dilated cardiomyopathy
Tarazon, E.; (...); Rosello-Lleti, E.
Meeting Abstract. 2023
Altered MicroRNA Maturation in Ischemic Hearts: Implication of Hypoxia on XPO5 and DICER1 Dysregulation and RedoximiR State.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.3390/antiox12071337. 2023
Altered miRNA maturation in ischemic cardiomyopathy: implication of miRNA biogenesis and redox-sensitive miRNA regulation
Estefania Tarazon, E. T.; (...); Rosello-Lleti, E.
Meeting Abstract. 2023
Analysis of the snoRNA profile in ischemic and dilated cardiomyopathy
Tarazon, E.; (...); Rosello-Lleti, E.
Meeting Abstract. 2023
ASB1 differential methylation in ischaemic cardiomyopathy: relationship with left ventricular performance in end-stage heart failure patients
Ortega, A; (...); Rivera, M
Article. 10.1002/ehf2.12289. 2018
ATP synthase subunit alpha and LV mass in ischaemic human hearts
Roselló-Lletí E; (...); Rivera M
Article. 10.1111/jcmm.12477. 2015
BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.
Carnicer, Ricardo; (...); Casadei, Barbara
Article. 10.1161/CIRCRESAHA.120.316656. 2021
Cardiac Allograft Rejection Induces Changes in Nucleocytoplasmic Transport: RANGAP1 as a Potential Non-Invasive Biomarker.
Lozano-Edo, Silvia; (...); Martinez-Dolz, Luis
Article. 10.3390/jpm12060913. 2022
Cardiac rejection diagnosis using serum mRNA encoding proteins related to fibrotic process
Rosello-Lleti, E.; (...); Tarazon, E.
Meeting Abstract. 2023
Cardiac S1P/Ceramide imbalance in human heart failure: implication of gene dysregulation
Perez Carrillo, L.; (...); Tarazon, E.
Meeting Abstract. 2021
Cardiac sodium/hydrogen exchanger (NHE11) as a novel potential target for SGLT2i in heart failure
Perez-Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
CCSER2 and RAC3 serum expression levels detect cardiac allograft rejection
Rodriguez, J. M.; (...); Rosello-Lleti, E.
Meeting Abstract. 2021
Circulating long non-coding RNAs detection after heart transplantation and its accuracy in the diagnosis of acute cardiac rejection.
Pérez-Carrillo L; (...); Roselló-Lletí E
Letter. 10.1186/s40364-024-00590-0. 2024
Circulating mitochondrial genes detect acute cardiac allograft rejection: Role of the mitochondrial calcium uniporter complex.
Tarazón E; (...); Roselló-Lletí E
Article. 10.1111/ajt.16387. 2020
Circulating sphingosine-1-phosphate as a non-invasive biomarker of heart transplant rejection
ROSELLO, E.; (...); PORTOLES, M.
Meeting Abstract. 2019
Circulating Sphingosine-1-Phosphate as A Non-Invasive Biomarker of Heart Transplant Rejection.
TARAZON, E.; (...); ROSELLO, E.
Article. 10.1038/s41598-019-50413-8. 2019
Combining Serum miR-144-3p and miR-652-3p as Potential Biomarkers for the Early Diagnosis and Stratification of Acute Cellular Rejection in Heart Transplantation Patients.
Pérez-Carrillo L; (...); Roselló-Lletí E
Article. 10.1097/TP.0000000000004622. 2023
Combining serum miR-144-3p and miR-652-3p as potential biomarkers for the early diagnosis and stratification of acute cellular rejection in heart transplantation patients
Perez-Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Correlation of various molecules involved in cellular traffic with the severity of heart failure in patients undergoing cardiac transplantation
Ezzitouny, M.; (...); Martinez-Dolz, L.
Meeting Abstract. 2018
Changes in human Golgi apparatus reflect new left ventricular dimensions and function in dilated cardiomyopathy patients
Tarazon, E; (...); Rivera, M
Letter. 10.1002/ejhf.671. 2017
Diagnostic value of serum miR-144-3p for the detection of acute cellular rejection in heart transplant patients.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.1016/j.healun.2021.10.004. 2022
Disturbance of iron metabolism related genes in advanced heart failure
Tarazon, E.; (...); Rosello-Lleti, E.
Meeting Abstract. 2023
DNMT3B System Dysregulation Contributes to the Hypomethylated State in Ischaemic Human Hearts
Tarazon, Estefania; (...); Rosello-Lleti, Esther
Article. 10.3390/biomedicines10040866. 2022
Electron microscopy reveals evidence of perinuclear clustering of mitochondria in cardiac biopsy proven allograft rejection
Rosello-Lleti, E.; (...); Portoles, M.
Meeting Abstract. 2019
Electron Microscopy Reveals Evidence of Perinuclear Clustering of Mitochondria in Cardiac Biopsy-Proven Allograft Rejection.
Tarazon, Estefania; (...); Rosello-Lleti, Esther
Article. 10.3390/jpm12020296. 2022
Emerging role of circulating piRNAs in the diagnosis of heart transplant rejection.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.1016/j.healun.2024.11.039. 2024
Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats.
Aragón-Herrera A; (...); Lago F
Article. 10.1016/j.bcp.2019.113677. 2019
Endolysosomal two-pore channels regulate autophagy in cardiomyocytes
Garcia-Rua, V; (...); Lago, F
Article. 10.1113/JP271332. 2016
Endoplasmic Reticulum Stress Induces Different Molecular Structural Alterations in Human Dilated and Ischemic Cardiomyopathy
Ortega A; (...); Portolés M
Article. 10.1371/journal.pone.0107635. 2014
Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy
Herrer I; (...); Rivera M
Article. 10.1186/s12920-015-0088-y. 2015
Golgi Apparatus fragmentation in dilated cardiomyopathy and its relationship with the alteration of vesicular transport
Gimenez-Escamilla, I.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Golgi ribbon integrity in human patients with chronic heart failure
Gimenez Escamilla, I.; (...); Tarazon, E.
Meeting Abstract. 2021
Heart Mitochondrial Proteome Study Elucidates Changes in Cardiac Energy Metabolism and Antioxidant PRDX3 in Human Dilated Cardiomyopathy
Roselló-Lletí E; (...); Rivera M
Article. 10.1371/journal.pone.0112971. 2014
Human Ischemic Cardiomyopathy Shows Cardiac Nos1 Translocation and its Increased Levels are Related to Left Ventricular Performance
Rosello-Lleti E; (...); Rivera M
Article. 10.1038/srep24060. 2016
Human recombinant relaxin-2 (serelaxin) regulates the proteome, lipidome, lipid metabolism and inflammatory profile of rat visceral adipose tissue.
Aragon-Herrera, Alana; (...); Lago, Francisca
Article. 10.1016/j.bcp.2024.116157. 2024
Impact of circulatory assistance in the early evolution after heart transplantation: unicentric experience.
Martinez-Lauwers, A.; (...); Martinez-Dolz, L.
Meeting Abstract. 2020
Implication of Sphingolipid Metabolism Gene Dysregulation and Cardiac Sphingosine-1-Phosphate Accumulation in Heart Failure.
Perez-Carrillo, Lorena; (...); Tarazon, Estefania
Article. 10.3390/biomedicines10010135. 2022
Implication of sphingolipid metabolism gene dysregulation and cardiac sphingosine-1-phosphate accumulation in heart failure
Perez Carrillo, L.; (...); Tarazon, E.
Meeting Abstract. 2021
Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function
Ortega, A; (...); Rivera, M
Article. 10.1371/journal.pone.0185062. 2017
iTRAQ proteomic analysis of extracellular matrix remodeling in aortic valve disease
Martin-Rojas T; (...); Barderas MG
Article. 10.1038/srep17290. 2015
Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level
Garcia-Rua, V; (...); Lago, F
Article. 10.1007/s12038-016-9647-4. 2016
METABOLIC PROFILING OF HEARTS FROM RATS TREATED WITH SERELAXIN
Aragon-Herrera, A; (...); Aragon-Herrera, A
Meeting Abstract. 2018
Metabolic profiling reveals significant alterations in glycerophospholipid and sphingolipid content in hearts from rats treated with relaxin
Aragon-Herrera, A; (...); Lago, F
Meeting Abstract. 2018
Meteorin-like plasma levels as a novel biomarker for heart failure
Feijoo-Bandin, S.; (...); Gonzalez-Juanatey, J. R.
Meeting Abstract. 2024
Meteorin-like protein plasma levels are associated with worse outcomes in de novo heart failure.
Anido-Varela, Laura; (...); Lago, Francisca
Article. 10.1111/eci.14380. 2025
Molecular Alterations of Nucleocytoplasmic Transport in Patients on the Heart Transplantation Waiting List and Its Correlation With the Severity and Etiology of Heart Failure.
Ezzitouny, M.; (...); Martinez-Dolz, L.
Article. 10.1016/j.transproceed.2018.12.013. 2019
Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis
Gil-Cayuela, C; (...); Portoles, M
Article. 10.1371/journal.pone.0190987. 2018
New Altered Non-Fibrillar Collagens in Human Dilated Cardiomyopathy: Role in the Remodeling Process
Gil-Cayuela, C; (...); Rivera, M
Article. 10.1371/journal.pone.0168130. 2016
New Cell Adhesion Molecules in Human Ischemic Cardiomyopathy. PCDHGA3 Implications in Decreased Stroke Volume and Ventricular Dysfunction
Ortega, Ana; (...); Rosello-Lleti, Esther
Article. 10.1371/journal.pone.0160168. 2016
Non-invasive diagnosis of cardiac rejection using small non-coding RNAs
Gimenez-Escamilla, I.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction
Ortega A; (...); Rivera M
Article. 10.1371/journal.pone.0145518. 2015
Plasma CD5L and non-invasive diagnosis of acute heart rejection.
Tarazón E; (...); Roselló-Lletí E
Article. 10.1016/j.healun.2019.11.004. 2020
Plasma fibroblast activation protein is decreased in acute heart failure despite cardiac tissue upregulation
Delgado-Arija, Marta; (...); Rosello-Lleti, Esther
Article. 10.1186/s12967-024-04900-w. 2024
Plasma Levels of SERCA2a as a Noninvasive Biomarker of Primary Graft Dysfunction After Heart Transplantation.
Lozano-Edo S; (...); Martínez-Dolz L
Article. 10.1097/TP.0000000000003798. 2021
Plasma levels of the proinflammatory adipocytokine chemerin correlate with lean/fat mass index in patients with heart failure
Herrera, AA; (...); Lago, F
Meeting Abstract. 2017
Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts
Rosello-Lleti E; (...); Rivera M
Article. 10.1038/srep30902. 2016
Protocol for Isolation of Golgi Vesicles from Human and Animal Hearts by Flotation through a Discontinuous Sucrose Gradient.
Tarazón E, Portolés M, Roselló-Lletí E
Article. 10.1016/j.xpro.2020.100100. 2020
Relationships of Telomere Homeostasis with Oxidative Stress and Cardiac Dysfunction in Human Ischaemic Hearts.
Tarazón E; (...); Roselló-Lletí E
Article. 10.3390/antiox10111750. 2021
Relaxin activates AMPK-AKT signaling and increases glucose uptake by cultured cardiomyocytes
Aragon-Herrera, A.; (...); Lago, F.
Article. 10.1007/s12020-018-1534-3. 2018
Relaxin has beneficial effects on liver lipidome and metabolic enzymes
Aragon-Herrera, A; (...); Lago, F
Article. 10.1096/fj.202002620RR. 2021
Relaxin-2 as a Potential Biomarker in Cardiovascular Diseases.
Aragon-Herrera, Alana; (...); Lago, Francisca
Article. 10.3390/jpm12071021. 2022
Relaxin-2 in Cardiometabolic Diseases: Mechanisms of Action and Future Perspectives
Feijoo-Bandin, S; (...); Lago, F
Article. 10.3389/fphys.2017.00599. 2017
Role of DNMT3B system in human ischemic hearts
Perez Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2021
Role of Sodium-Glucose Co-Transporter 2 Inhibitors in the Regulation of Inflammatory Processes in Animal Models.
Feijoo-Bandin, Sandra; (...); Lago, Francisca
Article. 10.3390/ijms23105634. 2022
Sarcomere ACTC1 and MYO18A serum expression levels detect acute cellular rejection in cardiac transplant patients
Perez Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2021
SERCA2a: A potential non-invasive biomarker of cardiac allograft rejection
Tarazon, E; (...); Rosello-Lleti, E
Article. 10.1016/j.healun.2017.07.003. 2017
Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue
Aragon-Herrera, A; (...); Lago, F
Article. 10.1016/j.phrs.2019.04.009. 2019
Study of molecules involved in cellular traffic in advanced heart failure: are there differences in the nivels of these molecules between ischemic heart disease and idiopathic dilated cardiomyopathy?
Ezzitouny, M.; (...); Martinez-Dolz, L.
Meeting Abstract. 2018
The Adipokine Chemerin Induces Apoptosis in Cardiomyocytes
Rodríguez-Penas D; (...); Lago F
Article. 10.1159/000430343. 2015
The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy
Gil-Cayuela, C; (...); Portoles, M
Article. 10.1371/journal.pone.0215818. 2019
The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 decrease left ventricular function in human dilated cardiomyopathy
Rosello-Lleti, E; (...); Portoles, M
Meeting Abstract. 2019
The central role of FAP dysregulation and cardiac fibroblast activation in heart failure patients
Rosello-Lleti, E.; (...); Tarazon, E.
Meeting Abstract. 2023
The lipidomic and inflammatory profiles of visceral and subcutaneous adipose tissues are distinctly regulated by the SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats.
Aragon-Herrera, Alana; (...); Lago, Francisca
Article. 10.1016/j.biopha.2023.114535. 2023
The Treatment With the SGLT2 Inhibitor Empagliflozin Modifies the Hepatic Metabolome of Male Zucker Diabetic Fatty Rats Towards a Protective Profile.
Aragon-Herrera, Alana; (...); Lago, Francisca
Article. 10.3389/fphar.2022.827033. 2022
Thyroid hormone biosynthesis machinery is altered in the ischemic myocardium: An epigenomic study
Gil-Cayuela, C; (...); Portoles, M
Article. 10.1016/j.ijcard.2017.05.042. 2017
Transcriptomic Alterations in Spliceosome Components in Advanced Heart Failure: Status of Cardiac-Specific Alternative Splicing Factors
Gimenez-Escamilla, Isaac; (...); Rosello-Lleti, Esther
Article. 10.3390/ijms25179590. 2024
TRPM7 is down-regulated in both left atria and left ventricle of ischaemic cardiomyopathy patients and highly related to changes in ventricular function.
Ortega, A; (...); Rivera, M
Article. 10.1002/ehf2.12085. 2016
Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions
Feijoo-Bandin, S; (...); Lago, F
Review. 10.1080/19336950.2016.1213929. 2017
Utility of nucleocytoplasmic transport as a marker in critical heart failure with circulatory assistance as a bridge to transplant
Ezzitouny, M.; (...); Marinez-Dolz, L.
Meeting Abstract. 2020
Value of SERCA2a as a Biomarker for the Identification of Patients with Heart Failure Requiring Circulatory Support.
Ezzitouny M; (...); Martínez-Dolz L
Article. 10.3390/jpm11111122. 2021
XPO1 Gene Therapy Attenuates Cardiac Dysfunction in Rats with Chronic Induced Myocardial Infarction.
García-Manzanares M; (...); Rivera M
Article. 10.1007/s12265-019-09932-y. 2020
Campos de Estudio
Cita
PAPEL PROTECTOR DE BH4 EN LA DISFUNCIÓN VENTRICULAR. UNA PROMETEDORA ESTRATEGIA TERAPÉUTICA EN LA. (CAS14/00111). FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; MINISTERIO DE EDUCACION, CULTURA Y DEPORTE. 2014-2015. IP:ESTHER ROSELLÓ LLETÍ.