Portal de investigación
ROTF. FAST METABOLOMIC ASSESSMENT OF DONOR LIVER QUALITY PRIOR TO TRANSPLANT.
Datos básicos
- Protocolo:
- 2014_0081_PE_ROTF_LAHOZ
- EUDRACT:
- NCT:
- Centro:
- Año de incio:
- 2014
- Año de finalización:
- 2018
Objetivos del proyecto
FAVORABLE
Documentos
- No hay documentos
Participantes
Grupos
Resultados del Ensayo Clínico
A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis
Garcia-Canaveras, JC; (...); Lahoz, A
Article. 10.1002/elps.201700079. 2017
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
García-Cañaveras JC; (...); Lahoz A
Article. 10.1038/srep27239. 2016
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity
Article. 10.1002/lt.23990. 2015
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity Reply
Hervás D, Lahoz A
Letter. 10.1002/lt.24408. 2016
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.
Ghergurovich JM; (...); Rabinowitz JD
Article. 10.1038/s41589-020-0533-x. 2020
Baseline circulating myeloid-derived suppressor cells correlate with neutrophil-to-lymphocyte ratio and overall survival in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors
Garcia-Sanchez, J.; (...); Lahoz, A.
Meeting Abstract. 2021
Baseline circulating myeloid-derived suppressor cells subpopulations, neutrophils/lymphocytes ratio, and response to PD-1/PD-L1 inhibitor in non-small cell lung cancer patients.
SAnchez, JosE GarcIa; (...); Lahoz, Agustin
Meeting Abstract. 2020
Beneficial effects of hepatic cyclooxygenase-2 expression against cholestatic injury after common bile duct ligation in mice.
Brea, Rocio; (...); Frances, Daniel E
Article. 10.1111/liv.16004. 2024
Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial.
Sowah, Solomon A.; (...); Zeller, Georg
Article. 10.1186/s13073-022-01030-0. 2022
cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants
Olivares-González L; (...); Rodrigo R
Article. 10.1371/journal.pone.0166717. 2016
c-MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency
Prieto, Javier; (...); Torres, Josema
Article. 10.1007/s12015-021-10239-2. 2021
CXCR7 reactivates ERK signaling to promote resistance to EGFR kinase inhibitors in NSCLC.
Becker JH; (...); Shimamura T
Article. 10.1158/0008-5472.CAN-19-0024. 2019
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.
Gomez-Escribano, Ana P.; (...); Vazquez-Manrique, Rafael P.
Article. 10.15252/embr.202255556. 2023
Chemokine Receptor CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Becker, J; (...); Shimamura, T
Meeting Abstract. 10.1016/j.jtho.2019.08.1478. 2019
Chronological and Biological Age as a Response Factor to Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer
Suay, G.; (...); Juan-Vidal, O.
Meeting Abstract. 2024
Development of primary human NSCLC patient derived xenograft and organoids models as a precision approach to tumor treatment
Vidal, OJJ; (...); Farras, R
Meeting Abstract. 2018
Early radiological response as predictor of overall survival in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor mutations
Salvador-Coloma, C; (...); Juan, O
Article. 10.21037/jtd.2018.02.30. 2018
Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma
Pulido, I; (...); Shimamura, T
Article. 10.1158/0008-5472.CAN-20-0141. 2020
Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1007/s00216-015-9227-8. 2016
FAMetA: a mass isotopologue-based tool for the comprehensive analysis of fatty acid metabolism.
Alcoriza-Balaguer MI; (...); Lahoz A
Article. 10.1093/bib/bbad064. 2023
Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer's disease
Correas, Angela G.; (...); Vina, Jose
Article. 10.1016/j.redox.2024.103242. 2024
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells
Ballester, M; (...); Bort, R
Article. 10.1038/s41598-019-54357-x. 2019
Identification of a Novel Synthetic Lethal Vulnerability in Non-Small Cell Lung Cancer by Co-Targeting TMPRSS4 and DDR1
Redin, E; (...); Calvo, A
Meeting Abstract. 10.1016/j.jtho.2019.08.1485. 2019
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1
Villalba, Maria; (...); Calvo, Alfonso
Article. 10.1038/s41598-019-51066-3. 2019
Immune checkpoint inhibitors as first-line treatment for brain metastases in stage IV NSCLC patients without driver mutations
Suay, Guillermo; (...); Lahoz, Agustin
Review. 10.1016/j.canlet.2024.217317. 2024
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8(+) T cell stemness and antitumor immunity
Hermans, D; (...); Leonard, WJ
Article. 10.1073/pnas.1920413117. 2020
LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1002/elps.201500095. 2015
LipidMS 3.0: an R-package and a web-based tool for LC-MS/MS data processing and lipid annotation.
Alcoriza-Balaguer MI; (...); Lahoz, Agustin
Article. 10.1093/bioinformatics/btac581. 2022
LipidMS: An R Package for Lipid Annotation in Untargeted Liquid Chromatography-Data Independent Acquisition-Mass Spectrometry Lipidomics
Alcoriza-Balaguer, MI; (...); Lahoz, A
Article. 10.1021/acs.analchem.8b03409. 2019
Metabolic vulnerabilities of mesenchymal-like EGFR-mutant NSCLC cells with acquired resistance to tyrosine kinase inhibitors
Pulido, I; (...); Carretero, J
Meeting Abstract. 10.1158/1538-7445.AM2018-LB-099. 2018
Metabolomics of Plasma in XLH Patients with Arterial Hypertension: New Insights into the Underlying Mechanisms
Lopez-Romero, Luis Carlos; (...); Hernandez-Jaras, Julio
Article. 10.3390/ijms25063545. 2024
Methods for analysis of specific DNA methylation status.
Pajares MJ; (...); Sandoval J
Article. 10.1016/j.ymeth.2020.06.021. 2020
Mild Muscle Mitochondrial Fusion Distress Extends Drosophila Lifespan through an Early and Systemic Metabolome Reorganization.
Tapia A; (...); Galindo MI
Article. 10.3390/ijms222212133. 2021
miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review.
García-Giménez JL; (...); Mena-Molla S
Article. 10.3390/ijms25031737. 2024
Non-Invasive Infections Diagnosis in Lung Transplant Recipients in Exhaled Breath Condensate
Ibanez-Martinez, E.; (...); Sole-Jover, A.
Meeting Abstract. 2021
PLEIOTROPIC EFFECT OF MIR-146A CAUSES PLATELET HYPERREACTIVITY AND THROMBOSIS THROUGH METABOLIC ICA REPROGRAMMING
Sonia, Aguila; (...); Constantino, Martinez
Meeting Abstract. 2021
Pre-diagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma.
Stepien, Magdalena; (...); Jenab, Mazda
Article. 10.1002/ijc.33885. 2022
Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study.
Kühn T; (...); Kaaks R
Article. 10.1093/jnci/djz166. 2020
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial
Review. 2021
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial.
Article. 10.1016/j.aca.2020.12.025. 2021
Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity.
Canovas-Cervera, Irene; (...); Mena-Molla, Salvador
Article. 10.1016/bs.ircmb.2024.08.002. 2025
RpeakChrom: Novel R package for the automated characterization and optimization of column efficiency in high-performance liquid chromatography analysis
Peris-Diaz, MD; (...); Lahoz, A
Article. 10.1002/elps.201700180. 2017
Sex Differences in the Efficacy of Immune Checkpoint Inhibitors in Neoadjuvant Therapy of Non-Small Cell Lung Cancer: A Meta-Analysis
Suay, Guillermo; (...); Juan-Vidal, Oscar
Review. 10.3390/cancers15184433. 2023
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia.
García-Cañaveras JC; (...); Rabinowitz JD
Article. 10.1038/s41375-020-0845-6. 2020
Sparse N-way partial least squares by L1-penalization
Hervas, D; (...); Ferrer, A
Article. 10.1016/j.chemolab.2019.01.004. 2019
Sparse N-way partial least squares with R package sNPLS
Hervas, D.; (...); Ferrer, A.
Article. 10.1016/j.chemolab.2018.06.005. 2018
Starkeya nomas sp. nov., a prosthecate and budding bacterium isolated from an immunocompromized patient.
Sahuquillo-Arce JM; (...); López-Hontangas JL
Article. 10.1099/ijsem.0.005805. 2023
STEROID HORMONE SIGNALING MAY REGULATE HOMEOSTASIS OF POLYQ-CONTAINING PROTEINS IN C. ELEGANS
Gomez-Escribano, A. P.; (...); Vazquez-Manrique, R.
Meeting Abstract. 10.1136/jnnp-2018-EHDN.26. 2018
Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity
Garcia, Ana Garcia; (...); Sanchez-Arevalo Lobo, Victor Javier
Article. 10.1038/s41467-025-56894-8. 2025
The Potential Role of Efficacy and Safety Evaluation of N-Acetylcysteine Administration During Liver Procurement. The NAC-400 Single Center Randomized Controlled Trial
Gomez-Gavara, C; (...); Lopez-Andujar, R
Article. 10.1097/TP.0000000000003487. 2021
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
Fernández-Álvarez S; (...); Beraza N
Article. 10.1038/labinvest.2014.151. 2015
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer
Palanca-Ballester, Cora; (...); Sandoval, Juan
Article. 10.1186/s13148-022-01334-3. 2022
Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers
Review. 10.3390/cancers13133230. 2021
Xenobiotic metabolism in differentiated human bronchial epithelial cells
Boei JJWA; (...); Vrieling, H
Article. 10.1007/s00204-016-1868-7. 2017