Circulating activated protein C is reduced in young survivors of myocardial infarction and inversely correlates with the severity of coronary lesions.

Autores de IIS La Fe

• 

  Esther Zorio Grima

  Autor

• Silvia Navarro Rosales

  Autor

• 

  Pilar Medina Badenes

  Autor

• Amparo Estelles Cortes

  Autor

• Ana María Osa Sáez

  Autor

• Joaquín Rueda Soriano

  Autor

• Pilar Cubillo Font

  Autor

• Justo Aznar Lucea

  Autor

• Francisco España Furio

  Autor

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

Cardiovascular risk factors for myocardial infarction (MI) are less frequent in younger than in older MI survivors. Therefore, the thrombotic component of MI may play a more important role at a young age. As activated protein C (APC) provides systemic anticoagulant and anti-inflammatory protection, a low plasma APC level may be an arterial thrombotic risk factor.