Magnetic resonance imaging and optical coherence tomography correlations in multiple sclerosis beyond anatomical landmarks

Autores de IIS La Fe

• Antonio Barreiro González

  Autor

• Sara Carratalà Boscà

  Autor

• Francisco Carlos Pérez Miralles

  Autor

• Ana Alcalá Jordán

  Autor

• Joan Octavi Carreres Polo

  Autor

• Enrique España Gregori

  Autor

• Bonaventura Casanova Estruch

  Autor

Participantes ajenos a IIS La Fe

• Sanz M.T.

Grupos

• Investigación en Neuroinmunología y Esclerosis Múltiple

Abstract

Objective: To investigate multiple sclerosis (MS) optical coherence tomography (OCT) cross-sectional correlations with central nervous system (CNS) magnetic resonance imaging (MRI). Material and methods: Peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner (INL) and outer nuclear layer (ONL) of 54 relapsing remitting (RRMS) and 38 progressive (PMS, 9 primary and 29 secondary) patients were measured. With less than 3 months brain parenchymal fraction (BPF), spinal cord (SC), total gray matter (GM) and white matter volumes were calculated. Demographical and clinical data was compared according to the history of optic neuritis (HON). Relationships between OCT and MRI data were assessed using multivariable linear regression models, adjusting for age, gender and disease duration, taking into account HON and disease subtype. Results: Cerebellum (p = 0.008), pRNFL (p = 0.001), GCL (p = 0.001) and IPL (p = 0.001) were thinner, while INL was thicker (p = 0.02) if HON. SC correlated better with nasal pRNFL sectors in eyes with HON (all eyes: average pRNFL p = 0.035 ?2 = 0.213; N-pRNFL p = 0.04 ?2 = 0.36, NI-pRNFL p = 0.0001 ?2 = 0.484. RRMS eyes: N-pRNFL p = 0.034 ?2 = 0.348; NI-pRNFL p = 0.013 ?2 = 0.441), while it correlates with PMB (p = 0.032 ?2 = 0.144), GCL (p = 0.03 ?2 = 0.147) and IPL (p = 0.028 ?2 = 0.151) in eyes without HON regardless of the disease subtype. INL presented no microcystic macular oedema and was inversely associated with BPF (p = 0.029 ?2 = 0.363) and cerebellum (p = 0.015 ?2 = 0.428) in PMS eyes without HON. Conclusions: OCT data correlates with different CNS compartments, even with no anatomical or functional linkage, serving as useful neurodegeneration and inflammation surrogate marker. © 2020 Elsevier B.V.

Keywords

• Cross-Sectional Studies; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Retinal Ganglion Cells; Tomography, Optical Coherence; alemtuzumab; azathioprine; beta1a interferon; cyclophosphamide; fingolimod; fumaric acid dimethyl ester; gadolinium; glatiramer; interferon beta serine; natalizumab; ocrelizumab; peginterferon beta1a; rituximab; teriflunomide; adult; age; aged; anatomic landmark; Article; bone marrow transplantation; brain parenchymal fraction; brain size; central nervous system; cerebellum; cohort analysis; correlation coefficient; cross-sectional study; demography; disease duration; female; gender; gray matter; human; major clinical study; male; medical history; multiple sclerosis; nervous system parameters; neuroanatomy; neuroophthalmology; nuclear magnetic resonance imaging; observational study; optic neuritis; optical coherence tomography; papillomacular bundle; priority journal; prospective study; retina; retinal ganglion cell layer; retinal inner nuclear layer;