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  3. Establishing a Multicenter Personalized Medicine Program in Childhood, Adolescent, and Young Adult Cancer in Spain: The SEHOP-PENCIL Project.

Establishing a Multicenter Personalized Medicine Program in Childhood, Adolescent, and Young Adult Cancer in Spain: The SEHOP-PENCIL Project.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Vilaplana A
  • Carolina Torres A
  • Escudero López A
  • Izquierdo E
  • Manresa-Vera S
  • Alba-Pavón P
  • Alaña L
  • Gutierrez-Camino A
  • Rodríguez-Antolín C
  • Venegas Mascaró C
  • Paco Mercader S
  • Salvador N
  • Chamorro-Vera A
  • Imízcoz T
  • Panizo Morgado E
  • Vergara-Muñoz B
  • Castañeda Heredia A
  • Rovira Zurriaga C
  • Valero-Arrese L
  • Díaz-Merchán R
  • Manzano-Benito I
  • Cervera ST
  • García-Calvo L
  • Jiménez I
  • Domínguez-Pinilla N
  • Nova-Lozano C
  • Cuadrado-Torroglosa I
  • Sánchez-Ruiz J
  • Mondejar T
  • Pérez-Martínez A
  • Fernández-Teijeiro A
  • Solano-Páez P
  • Roma J
  • Meléndez B
  • Rubio-San-Simón A
  • Saiz-Ladera C
  • Astigarraga I
  • Alonso J
  • Lavarino C
  • Patiño-García A
  • Moreno L
  • Soriano A
  • SEHOP-PENCIL Consortium

Grupos

Abstract

Pediatric cancer care in Spain lacked a national personalized medicine program. The SEHOP-PENCIL initiative, established by the SEHOP, was designed to address this gap. A national survey identified the genomic sequencing needs of hospitals treating pediatric patients with cancer. Results showed improved access to targeted next-generation sequencing panels but revealed persistent variability in implementation, limited availability of advanced sequencing (whole-exome sequencing, whole-genome sequencing, RNA sequencing, and DNA methylation profiling), and gaps in cancer predisposition clinics and molecular tumor boards (MTBs). SEHOP-PENCIL is organized as a network of 10 specialized genomic centers serving 45 hospitals through a centralized inclusion system. The program standardizes patient eligibility, genomic workflows, and result interpretation, supported by a national MTB. This framework enables informed clinical decision making, ensures access to molecular diagnosis and innovative therapies, and supports systematic data collection to advance pediatric cancer research and personalized care. SEHOP-PENCIL represents a pioneering national model for integrating precision oncology into pediatric cancer care in Spain. By fostering collaboration, standardizing genomic practices, and promoting equitable access, it aims to reduce disparities and improve outcomes, offering a scalable example for other decentralized health care systems.

Datos de la publicación

ISSN/ISSNe:
2473-4284, 2473-4284

JCO Precision Oncology  LIPPINCOTT WILLIAMS & WILKINS

Tipo:
Article
Páginas:
-
PubMed:
42679328
Factor de Impacto:
2,116 SCImago ℠
Cuartil:
Q1 SCImago ℠

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