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Molecular Cages as Probes in Indicator Displacement Assays: The Case of Scopolamine Detection.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Montà-González G
  • Garrido E
  • Vicent C
  • Martí-Centelles V

Grupos

Abstract

A study of the Pd-based molecular cage C1 host-guest properties against fluorescein and the drug scopolamine is reported. C1 forms an interpenetrated structure C1(2) in the presence of =40% water in H(2)O/DMSO solvent mixtures. The presence of fluorescein (FL) induces the disassembly of the C1(2) structure to form the [FL(2)?C1] complex. Moreover, the addition of scopolamine (SCOP, a drug typically involved in drug-facilitated sexual assaults) to [FL(2)?C1] results in fluorescein release and the formation of [SCOP?C1(2)], obtaining a fluorescence signal proportional to the concentration of scopolamine with a limit of detection as low as 59.4 µg mL(-1). A good selectivity for scopolamine against other drugs such as MDMA, cocaine, GBL, and ketamine is observed. This is the first scopolamine detection method described to date using a molecular cage and one of the very few examples of the use of cages in indicator displacement assays. Similar concepts could be applied to the design of other molecular cage-based sensors for the detection of target analytes.

© 2025 Wiley-VCH GmbH.

Datos de la publicación

ISSN/ISSNe:
1433-7851, 1521-3773

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  WILEY-V C H VERLAG GMBH

Tipo:
Article
Páginas:
-
PubMed:
41403338
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
5,126 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 1

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Keywords

  • Host–guest chemistry; Indicator displacement assays; Molecular cages; Scopolamine detection; Supramolecular chemistry

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