Antiangiogenic activity of aganirsen in nonhuman primate and rodent models of retinal neovascular disease after topical administration.

Autores de IIS La Fe

• Patricia Udaondo Mirete

  Autor

Participantes ajenos a IIS La Fe

• Cloutier F
• Lawrence M
• Goody R
• Lamoureux S
• Al-Mahmood S
• Colin S
• Ferry A
• Conduzorgues JP
• Hadri A
• Cursiefen C
• Viaud E
• Thorin E
• Chemtob S

Grupos

• 

  Biomedicina Molecular, Celular y Genómica

Abstract

Aganirsen, an antisense oligonucleotide inhibiting insulin receptor substrate (IRS)-1 expression, has been shown to promote the regression of pathologic corneal neovascularization in patients. In this study, the authors aimed to demonstrate the antiangiogenic activity of aganirsen in animal models of retinal neovascularization.