Portal de investigación
Photothermic Release of Curcumin for Antimicrobial Photodynamic Therapy
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Trigo-Gutierrez, JK
- Mima, EGO
Grupos
Abstract
Drug delivery systems (DDS) are promising tools to enhance antimicrobial Photodynamic Therapy (aPDT) by improving the targeted delivery and controlled release of photosensitizers. In this study, we introduce a light-responsive DDS based on curcumin-loaded mesoporous silica nanoparticles featuring a gold nanostar core and paraffin capping, designed specifically for near-infrared (NIR)-triggered photothermal release. This multicomponent nanoplatform uniquely combines photothermal activation with light-controlled drug delivery for antimicrobial applications. The synthesized nanoparticles exhibited a mean diameter below 500 nm, a polydispersity index of 0.154, and a surface charge of -21.9 mV. Upon NIR irradiation at 1200 J/cm(2), curcumin release was approximately 90%. In planktonic bacterial cultures, aPDT mediated by this system led to reductions of 3.16 log1 0 and 2.18 log1 0 in colony-forming units (CFUs) for Staphylococcus aureus and Pseudomonas aeruginosa, respectively. For bacterial biofilms, a higher curcumin concentration (1000 mu g/mL) resulted in CFU reductions of 2.16 log1 0 and 1.77 log1 0 for S. aureus and P. aeruginosa, respectively. This study demonstrated a NIR-activated nanocarrier for the controlled release of curcumin and effective inactivation of both planktonic and biofilm-associated bacteria-offering a new approach to improve the precision and efficacy of aPDT.
© 2025 The Authors. Published by American Chemical Society.
Datos de la publicación
- ISSN/ISSNe:
- 2470-1343, 2470-1343
- Tipo:
- Article
- Páginas:
- 58600-58609
- PubMed:
- 41502716
- Factor de Impacto:
- 0,708 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
ACS Omega AMER CHEMICAL SOC
Citas Recibidas en Web of Science: 1
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- No hay documentos
Filiaciones
Cita
Trigo JK,MEDAGLIA S,AZNAR E,MARTINEZ R,Mima E. Photothermic Release of Curcumin for Antimicrobial Photodynamic Therapy. ACS Omega. 2025. 10. (48):p. 58600-58609. IF:5,200. (2).