Rhupus syndrome: Description of 9 cases with special attention to the HLA-DR genotype

Autores de IIS La Fe

• Isabel Martínez Cordellat

  Autor

• Elena Grau García

  Autor

• 

  José Andrés Román Ivorra

  Autor

Participantes ajenos a IIS La Fe

• Hurtado, AP
• Mazario, RG

Grupos

• Reumatología

Abstract

Background and objectives: Rhupus is a very rare syndrome of overlapping rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), characterized by the presence of erosive polyarthritis associated with symptoms and signs of SLE and the presence of high specificity autoantibodies. The analysis of HLADR molecules would allow us to genetically characterize patients diagnosed with rhupus, being able to differentiate them from the HLA-DR profile of patients with RA and SLE. Materials and methods: Cross-sectional observational study of 9 patients diagnosed with rhupus in whom the HLA-DR genotype was genetically characterized. Results: Rhupus is usually more frequent in women with initial diagnosis of RA. The most frequent clinical manifestations are articular and, serologically, ANA, RF and anti-CCP positivity stand out. The most frequent HLA-DR were HLA-DR1, HLA-DR3, HLA-DR4, HLA-DR7 and HLA-DR13. Conclusions: A higher proportion of HLA-DR1 and DR9 was observed in patients with rhupus compared to RA and SLE, as well as a lower proportion of HLA-DR2, DR6 and DR8, which would help the early characterization of these patients prior to the overlap diagnosis. (c) 2024 Elsevier Espana, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

Keywords

• Rhupus syndrome; Overlap syndrome; Rheumatoid arthritis; Systemic lupus erythematosus; HLA-DR; HLA