Renal-clearable probes for disease detection and monitoring.

Autores de IIS La Fe

• Alba García Fernández

  Autor

• Félix Sancenón Galarza

  Autor

• Ramón Martínez Máñez

  Autor

Participantes ajenos a IIS La Fe

• Dominguez, Marcia
• Marti-Centelles, Vicente
• Blandez, Juan F

Grupos

• Unidad Mixta de Investigación en Nanomedicina y Sensores

Abstract

The demand for novel, minimally invasive, cost-effective, and easily readable diagnostic tools, primarily designed for the longitudinal monitoring of diseases and their treatments, has promoted the development of diagnostic systems that selectively target cells, tissues, or organs, at the same time minimizing their nonspecific accumulation, thus reducing the risk of toxicity and side effects. In this review, we explore the development of renal-clearable systems in non-invasive or minimally invasive detection protocols, all with the objective of minimizing nonspecific accumulation and its associated toxicity effects through quick renal excretion. These probes can identify molecules of interest or different healthy states of the patients through the direct analysis of urine (urinalysis). As we discuss, these diagnostics systems hold significant treatment monitoring potential.

Published by Elsevier Ltd.

Keywords

• diagnostic tools; metal nanoparticles; molecular probes; polymeric nanoparticles; renal clearable