A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme.

Autores de IIS La Fe

• Félix Sancenón Galarza

  Autor

• Ramón Martínez Máñez

  Autor

Participantes ajenos a IIS La Fe

• Dominguez, Marcia
• Meyer, Kathleen
• Blandez, Juan F.
• Serrano, Manuel

Grupos

• Unidad Mixta de Investigación en Nanomedicina y Sensores

Abstract

Kidney damage generates changes at the phenotypic and genotypic levels that allow its monitoring using different biomarkers in blood, urine or serum. Among these biomarkers, kidney failure causes the urine overrepresentation of the alanine aminopeptidase (APN) enzyme. Here, we describe the design of a molecular probe (NB-ALA) based on the Nile Blue fluorophore (NB), which can detect the APN enzyme in urine by simple fluorometric measurements.

Keywords

• KIDNEY INJURY