Portal de investigación
A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Mayol, Beatriz
- Diez, Paula
- Sanchez, Alfredo
- de la Torre, Cristina
- Villalonga, Anabel
- Lucena-Sanchez, Elena
- Martinez-Ruiz, Paloma
- Vilela, Diana
- Villalonga, Reynaldo
Grupos
Abstract
This work describes the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice was constructed on Au-mesoporous silica Janus nanoparticles capped with a thiol-sensitive gate-like molecular ensemble on the mesoporous face and functionalized with glutathione reductase on the gold face. This autonomous nanomachine employed NADPH and glutathione disulfide as input chemical signals, leading to the enzymatic production of reduced glutathione that causes the disruption of the gating mechanism on the mesoporous face and the consequent payload release as an output signal. The nanodevice was successfully used for the autonomous release of doxorubicin in HeLa cancer cells and RAW 264.7 macrophage cells.
Datos de la publicación
- ISSN/ISSNe:
- 2040-3364, 2040-3372
- Tipo:
- Article
- Páginas:
- 18616-18625
- DOI:
- 10.1039/d0nr08282a
- PubMed:
- 34734589
- Factor de Impacto:
- 1,744 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Nanoscale ROYAL SOC CHEMISTRY
Citas Recibidas en Web of Science: 8
Documentos
- No hay documentos
Filiaciones
Keywords
- MESOPOROUS SILICA NANOPARTICLES; CARGO DELIVERY; REDUCTASE; PEROXIDASE; FTIR
Cita
Mayol B,Diez P,Sanchez A,de la Torre C,Villalonga A,Lucena E,SANCENON F,Martinez P,Vilela D,MARTINEZ R,Villalonga R. A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery. Nanoscale. 2021. 13. (44):p. 18616-18625. IF:8,307. (1).